Results 51 to 60 of about 6,856 (183)

Leishmanicidal activity of Piper nigrum bioactive fractions is interceded via apoptosis in vitro and substantiated by Th1 immunostimulatory potential in vivo

Frontiers in Microbiology, 2015
VL is a life-threatening protozoal infection chiefly impinging the rural and poor population in the tropical and sub-tropical countries. The deadly affliction is rapidly expanding after its association with AIDS, swiftly defying its status of a neglected
Garima eChouhan, Mohammad eIslamuddin, Muzamil Yaqub Want, Hani A Ozbak, Hassan A Hemeg, DINKAR eSAHAL, Farhat eAfrin, Farhat eAfrin   +7 more
doaj   +1 more source

Antiprotozoal Activity of Thymoquinone (2-Isopropyl-5-methyl-1,4-benzoquinone) for the Treatment of Leishmania major-Induced Leishmaniasis: In Silico and In Vitro Studies

Antibiotics, 2022
Leishmaniasis, a neglected tropical parasitic disease (NTPD), is caused by various Leishmania species. It transmits through the bites of the sandfly.
Kamal A. Qureshi, Mahrukh Imtiaz, Ibrahim Al Nasr, Waleed S. Koko, Tariq A. Khan, Mariusz Jaremko, Syed Mahmood, M. Qaiser Fatmi   +7 more
doaj   +1 more source

Aloe vera in Food Preservation: Harnessing Bioactive Constituents for Clean‐Label Innovation and Safety Assurance

Food Safety and Health, Volume 4, Issue 3, Page 574-599, July 2026.
Aloe vera‐derived biopolymers and nanoformulations enhance antimicrobial, antioxidant, and barrier functions in clean‐label edible coatings and films, whereas safety‐critical anthraquinone thresholds and regulatory constraints shape their translational potential.
Acharya Balkrishna, Hemant Sharma, Sonam Verma, Amar Jeet, Sumit Kumar Singh, Sharad Kumar Tripathi, Vedpriya Arya   +6 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Essential oil from Thymelaea tartonraira was characterized by GC–MS and evaluated using in vitro and in silico approaches. The oil exhibited notable antiplatelet activity with low cytotoxicity. Molecular docking revealed strong interactions of major compounds with GPVI, COX‐1, and P2Y12, supporting its potential as a natural antiplatelet agent ...
Siwar Soltani, Asma Haffouz, Imed Koubaa, Ali Gargouri, Amira Jerbi, Ikram Ben Amor, Jalel Gargouri, Basma HadjKacem, Noureddine Allouche   +8 more
wiley   +1 more source

Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity

International Journal of Nanomedicine, 2019
Prakash Kumar,1 Pushkar Shivam,*,2 Saptarshi Mandal,*,3 Pragya Prasanna,1 Saurabh Kumar,1 Surendra Rajit Prasad,1 Ashish Kumar,4 Prolay Das,3 Vahab Ali,5 Shubhankar Kumar Singh,2 Debabrata Mandal11Department of Biotechnology, National Institute of ...
Kumar P, Shivam P, Mandal S, Prasanna P, Kumar S, Prasad SR, Kumar A, Das P, Ali V, Singh SK, Mandal D   +10 more
doaj  

Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di-N-Oxides Containing an Amino Acidic Side Chain

Pharmaceuticals
We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity.
Juan F. González, María-Auxiliadora Dea-Ayuela, Lena Huck, José María Orduña, Francisco Bolás-Fernández, Elena de la Cuesta, Nazia Haseen, Ashraf Ali Mohammed, J. Carlos Menéndez   +8 more
doaj   +1 more source

Exploring the role of medicinal plant-based immunomodulators for effective therapy of leishmaniasis

Frontiers in Immunology, 2014
Leishmaniasis is a pestilent affliction that importunately needs better therapeutics necessitated by absence of effective vaccine, emergence as HIV co-infection and the dread of debilitating chemotherapy.
Garima eChouhan, Mohammad eIslamuddin, Dinkar eSahal, Farhat eAfrin   +3 more
doaj   +1 more source

Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives

BMC Chemistry, 2022
Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted-4(3H)-quinazolinones were synthesized via cyclization, condensation, and
Girma Worku Seifu, Yihenew Simegniew Birhan, Botros Youssef Beshay, Ariaya Hymete, Adnan Ahmed Bekhit   +4 more
doaj   +1 more source

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source