Results 1 to 10 of about 22,860 (171)
The regulation and biosynthesis of antimycins [PDF]
Beilstein Journal of Organic Chemistry, 2013 Antimycins (>40 members) were discovered nearly 65 years ago but the discovery of the gene cluster encoding antimycin biosynthesis in 2011 has facilitated rapid progress in understanding the unusual biosynthetic pathway. Antimycin A is widely used as a piscicide in the catfish farming industry and also has potent killing activity against insects ...
Seipke, Ryan F, Hutchings, Matthew I
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Coordinate Regulation of Antimycin and Candicidin Biosynthesis [PDF]
mSphere, 2016 Natural products produced by members of the phylum Actinobacteria underpin many industrially and medically important compounds; however, the majority of the ~30 biosynthetic pathways harbored by an average species are not expressed in the laboratory.
McLean, TC, Hoskisson, PA, Seipke, RF
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A phylogenetic and evolutionary analysis of antimycin biosynthesis [PDF]
Microbiology, 2017 Streptomyces species and other Actinobacteria are ubiquitous in diverse environments worldwide and are the source of, or inspiration for, the majority of antibiotics. The genomic era has enhanced biosynthetic understanding of these valuable chemical entities and has also provided a window into the diversity and distribution of ...
Joynt, Rebecca, Seipke, Ryan F.
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Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1995 The structural factors of antimycin A molecule required for inhibitory action were studied using newly synthesized antimycin A derivatives with bovine heart submitochondrial particles, in order to probe the interaction between antimycin A and its binding site.
Yasuhiro Imaeda +4 more
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The Journal of Antibiotics, 1970 Antimycin A is a complex of four major components designated as A1, A2, A3 and A4, which were isolated, A4 for the first time, in pure crystalline form. All components exhibited the same fungicidal activity, using Saccharomyces cerevisiae Y-30 as the test organism ; the higher activity of A3 reported before was found to be only apparent, and could be ...
Dieter Kluepfel +2 more
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Improved Synthesis of Antimycin A3 [PDF]
Bulletin of the Chemical Society of Japan, 1979 Abstract An improved synthesis of antimycin A3 was accomplished by a suitable lactonization of 3-O-benzyl or 3-O-isovaleryl derivative (10a or 10b) of (2R, 3R, 4S)-4-(N-benzyloxycarbonyl-l-threonyloxy)-2-butyl-3-hydroxypentanoic acid, which was synthesized by starting from the corresponding 3-O-benzyl or 3-O-isovaleryl derivative (4a or ...
Mitsuhiro Kinoshita, Shimpei Aburaki
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A Practical Total Synthesis of (+)-Antimycin A9 [PDF]
The Journal of Antibiotics, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mitsuyo Horikawa +4 more
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H+ production by antimycin-inhibited mitochondria [PDF]
Biochemical Journal, 1982 1. Oxygen-pulse experiments on antimycin-treated liver mitochondria from young rats in the absence of added substrates indicate the presence of an endogenous hydrogenated reductant on the oxygen side of the antimycin inhibition site. This reductant has been estimated to be present in a 20-50-fold molar excess over cytochrome aa3.
P Nicholls, J M Wrigglesworth
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Transcript Level Responses of Plasmodium falciparum to Antimycin A
Protist, 2012 The mitochondrial electron transport chain is essential to Plasmodium and is the target of the antimalarial drug atovaquone. The mitochondrial genomes of Plasmodium sp. are the most reduced known, and the majority of mitochondrial proteins are encoded in the nucleus and imported into the mitochondrion post-translationally.
Tarr, SJ, Nisbet, RER, Howe, CJ
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Antimycin A fermentation. I. Production and selection of strains.
The Journal of Antibiotics, 1976 Increase in antimycin A production was achieved through a parallel strain and medium improvement program: a 125-fold augmentation (75 to 9,500 mug/ml) was obtained. The selective system included antimycin A productivity, conidiation, sensitivity to ultraviolet radiation, growth rate and yield, and absence of pigment and actinomycin D production. Among
Claude Vezina +3 more
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