Results 61 to 70 of about 22,860 (171)

Transcriptome‐wide alternative mRNA splicing analysis reveals post‐transcriptional regulation of neuronal differentiation

The FEBS Journal, Volume 292, Issue 8, Page 2051-2070, April 2025.
During differentiation of SH‐SY5Y neuroblastoma cells to mature neuron‐like cells, transcriptome‐wide alternative splicing events occur in multiple local splice variant programs. These events are driven by RNA‐binding proteins (RBPs). Here, we utilize sequencing analysis to explore these events as well as identifying their potential RBP regulators via ...
Yuan Zhou, Sherif Rashad, Kuniyasu Niizuma   +2 more
wiley   +1 more source

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model

The FEBS Journal, EarlyView.
Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Andria Theodoulou, Thilo Speckmann, Louiza Potamiti, Otto Baba, Tsuyoshi Morita, Anthi Drousiotou, Mihalis I. Panayiotidis, Annette Schürmann, Petros P. Petrou   +8 more
wiley   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

TOTAL SYNTHESIS OF ANTIMYCIN A3

The Journal of Antibiotics, 1971
Mitsuhiro Kinoshita, Sumio Umezawa, Shimpei Aburagi, Masao Wada   +3 more
openaire   +4 more sources

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

Extracellular ATP: an emerging multifaceted regulator of plant fitness

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1771-1782, May 2025.
Summary Adenosine 5′‐triphosphate (ATP) is the energy currency of living organisms and the primary form of organic phosphate (Po) involved in cellular metabolism. In plants, some ATP is released into the extracellular matrix (ECM) in response to various stimuli, where it functions as extracellular ATP (eATP), a key signalling molecule.
De Peng Yuan, Daewon Kim, Yuan Hu Xuan
wiley   +1 more source

Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses. [PDF]

Sci Rep
Sutharsan R, Biaut Hontaas M, Li Y, Xiong H, Preckel H, Sue CM, Wali G.   +6 more
europepmc   +1 more source

A Holistic Investigation of Arabidopsis Proteomes Altered in Chloroplast Biogenesis and Retrograde Signalling Identifies PsbO as a Key Regulator of Chloroplast Quality Control

Plant, Cell &Environment, EarlyView.
ABSTRACT Communication between the diverse compartments of plant cells relies on an intricate network of molecular interactions that orchestrate organellar development and adaptation to environmental conditions. Plastid‐to‐nucleus signalling pathways play a key role in relaying information from developing, mature, and damaged or disintegrating ...
Dario Di Silvestre, Nicolaj Jeran, Guido Domingo, Candida Vannini, Milena Marsoni, Stefania Fortunato, Maria Concetta de Pinto, Alberto Tamborrino, Yuri Luca Negroni, Michela Zottini, Lien Tran Hong, Andrea Lomagno, Pierluigi Mauri, Paolo Pesaresi, Luca Tadini   +14 more
wiley   +1 more source

"Villains" Turning Good: Antimycin A and Rotenone, Mitochondrial Respiratory Chain Inhibitors, Protect H9c2 Cardiac Cells Against Insults Triggering the Intrinsic Apoptotic Pathway. [PDF]

Int J Mol Sci
Zikaki K, Kiachaki E, Gaitanaki C, Aggeli IK.   +3 more
europepmc   +1 more source