Advanced Science, EarlyView.ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang +10 more
wiley +1 more source
Redox Imbalance and Antioxidant Adaptation in Acute Ischemic Stroke: Temporal Changes in Enzymatic and Non-Enzymatic Markers. [PDF]
MoleculesGarbarek J +9 more
europepmc +1 more source
Advanced Science, EarlyView.This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang +14 more
wiley +1 more source
UPLC-MS/MS analysis and bioactivity comparison of wild and cultivated <i>Taihangia rupestris</i> leaves: antioxidant and α-glucosidase inhibitory activities with active compound screening. [PDF]
RSC AdvYin JT +6 more
europepmc +1 more source
Hydrothermal Humification of Biomass for Circular Carbon Management in Sustainable Agro‐Ecosystems
Advanced Science, EarlyView.This article provides a comprehensive overview of biomass hydrothermal humification for building sustainable agro‐ecosystems. It examines the chemical transformation mechanisms and the functional benefits of the produced humic acids in soil remediation.
Ziyun Liu +4 more
wiley +1 more source
Plant-Derived Bioactive Metabolites from the Sonoran Desert: Redox Regulation, Nrf2/NF-κB Signaling, and Emerging Therapeutic Applications. [PDF]
Int J Mol SciLewis-Luján LM +11 more
europepmc +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Effect of Starchy Wall Materials in the Microencapsulation of Carambola Fruit (<i>Averrhoa carambola</i>) Pulp: Antioxidant Characteristics. [PDF]
FoodsSantana-Galeana RS +4 more
europepmc +1 more source