Results 91 to 100 of about 162,577 (262)

Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells – a preliminary investigation [PDF]

, 2017
Ovarian cancer is one of the most common gynaecological cancers today. This study therefore investigates the anticancer effects of Ficus exasperata extracts and fractions on ovarian cancer cells. The antiproliferative activity of the crude extracts (1 mg/
Bafor, Enitome E., Edrada-Ebel, RuAngelie, McKenna, Jennifer, Rowan, Edward G.   +3 more
core   +1 more source

Antimicrobial property and antiproliferative activity of Centaurea babylonica (L.) L. on human carcinomas and cervical cancer cell lines

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective Since antiquity, C. babylonica (L.) L. extracts has been used as a remedy for primary health care in traditional medicine.
Nur Ceyhan Güvensen, Dilek Keskin, Hatice Güneş, Müjgan Kesik Oktay, Hasan Yıldırım   +4 more
doaj   +1 more source

Design and synthesis of novel oridonin analogues as potent anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties.
Qing-Kun Shen, Zheng-Ai Chen, Hong-Jian Zhang, Jia-Li Li, Chuan-Feng Liu, Guo-Hua Gong, Zhe-Shan Quan   +6 more
doaj   +1 more source

Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum

Marine Drugs, 2016
Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3–9), were isolated from the deep-sea-derived fungus Chaetomium globosum.
Zhihan Zhang, Xitian Min, Junjun Huang, Yue Zhong, Yuehua Wu, Xiaoxia Li, Yinyue Deng, Zide Jiang, Zongze Shao, Lianhui Zhang, Fei He   +10 more
doaj   +1 more source

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]

, 2009
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Aird, Ang, Barnard, Barnes, Bednarski, Bergamo, Bergamo, Bindoli, Campone, Chatterjee, Che, Chen, Chen, Chen, Chen, Choy, Clarke, Cordier, Desoize, Detty, Dougan, Ernst, Failes, Farrer, Feazell, Fricker, Gabbiani, Gunatilleke, Hall, Hambley, Hamelers, Henderson, Hillard, Hotze, Hotze, Jakupec, Jakupec, Junicke, Kelland, Kostenich, Kostova, Kostrhunova, Li, Mackay, Mackay, Meggers, Mosi, Nguyen, Noor, Oliveira, Ott, Ott, Ott, Peacock, Peacock, Peacock, Peter J. Sadler, Petzold, Petzold, Powis, Rademaker-Lakhai, Sabine H. van Rijt, Sadler, Saggioro, Sergeant, Sessler, Sharman, Shaw, Sherman, Smalley, Storr, Urig, van Rijt, Vessieres, Wang, Wang   +75 more
core   +1 more source

Chemical characterization, antiproliferative and antifungal activities of Clinacanthus nutans

, 2021
Wen Xu, Jiaying Li, Dongli Li, Junfeng Tan, Hang Ma, Yu Mu, Wen Yan, Li‐She Gan, Xueshi Huang, Liya Li   +9 more
openalex   +2 more sources

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties [PDF]

, 2022
Emna Choura, Fares Elghali, Paul J. Bernard, Dhouha Msalbi, José Marco‐Contelles, Sami Aifa, Lhassane Ismaïli, Fakher Chabchoub   +7 more
openalex   +1 more source

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

Molecules, 2016
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward ...
Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, Jan Balzarini   +8 more
doaj   +1 more source

β-Lapachone analogs with enhanced antiproliferative activity

European Journal of Medicinal Chemistry, 2012
In this study, we describe the synthesis of a series of α- and β-lapachone containing hydroxyl or methoxyl groups on the benzene ring, by means of the selective acid promoted cyclization of the appropriate lapachol analog. The evaluation of the antiproliferative activity in human solid tumor cell lines provided 7-hydroxy-β-lapachone as lead with ...
Ríos Luci, Carla, Bonifazi, Evelyn Lucia, Leon, Leticia G., Montero, Juan C., Burton, Gerardo, Pandiella, Atanasio, Misico, Rosana Isabel, Padron, Jose M.   +7 more
openaire   +4 more sources

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line.
Guangcheng Wang, Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li, Zhiyun Peng   +5 more
doaj   +1 more source