Results 101 to 110 of about 98,614 (298)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects

Molecules, 2013
Several diterpenes with the labdane skeleton show biological activity, including antiproliferative effects. Most of the research work on bioactive labdanes has been carried out on naturally occurring diterpenes and semisynthetic derivatives, but much ...
Guillermo Schmeda-Hirschmann, Marco Bastías, Cristina Theoduloz, Mariano Walter Pertino   +3 more
doaj   +1 more source

Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides

, 2006
The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells.
Jacobsson, Mårten, Mani, Katrin, Ellervik, Ulf, Belting, Mattias   +3 more
core   +1 more source

Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives [PDF]

, 2019
Aim: To develop several new derivatives aimed to complete the studies concerning the antiproliferative profile of the oxadiazole derivative MD77. Materials and Methods: The substitution pattern around the phenyl rings of this compound was analyzed ...
Mori, Matteo, Dalla Via, Lisa, STEFANIA VILLA, Ehrsam, Daniel, Gelain, Arianna, Porta, Fabiola, DANIEL EHRSAM, HENRIETTE E. MEYER ZU SCHWABEDISSEN, ARIANNA GELAIN, FABIOLA PORTA, LISA DALLA VIA, Meyer zu Schwabedissen, Henriette E., FIORELLA MENEGHETTI, Meneghetti, Fiorella, LIVIA BASILE, MATTEO MORI, Garcia-Argaez, Aìda Nelly, AÌDA NELLY GARCIA-ARGAEZ, Basile, Livia, Schwabedissen, Henriette E Meyer Zu, Villa, Stefania   +20 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Enhancement of antiproliferative activity by molecular simplification of catalpol

Bioorganic & Medicinal Chemistry, 2010
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed alpha-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86muM.
García, Celina, León, Leticia G., Pungitore, Carlos Rodolfo, Ríos Luci, Carla, Daranas, Antonio H., Montero, Juan C., Pandiella, Atanasio, Tonn, Carlos Eugenio, Martín, Víctor S., Padrón, José M.   +9 more
openaire   +4 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Therapeutic properties of some specific honey types [PDF]

Food and Feed Research
This paper examines the physicochemical characteristics, as well as the antioxidant, antibacterial, and antiproliferative effects, of several honey types that are commercially available but not typical of Serbia.
Sakač Marijana B., Jovanov Pavle, Marić Aleksandar, Plavšić Dragana, Jakimov Dimitar, Đermanović Branislava   +5 more
doaj   +1 more source