Results 101 to 110 of about 5,874,294 (289)

Investigating the Antiproliferative Activity of Synthetic Troponoids

, 2016
Troponoid (more commonly, tropone/tropolone) refers to a family of naturally occurring compounds with a unique seven-membered aromatic ring. As with many secondary metabolites, many of the tropolones display a wide range of biological activity.
Falcone, Eric R
core   +1 more source

Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives [PDF]

, 2019
Aim: To develop several new derivatives aimed to complete the studies concerning the antiproliferative profile of the oxadiazole derivative MD77. Materials and Methods: The substitution pattern around the phenyl rings of this compound was analyzed ...
Mori, Matteo, Dalla Via, Lisa, STEFANIA VILLA, Ehrsam, Daniel, Gelain, Arianna, Porta, Fabiola, DANIEL EHRSAM, HENRIETTE E. MEYER ZU SCHWABEDISSEN, ARIANNA GELAIN, FABIOLA PORTA, LISA DALLA VIA, Meyer zu Schwabedissen, Henriette E., FIORELLA MENEGHETTI, Meneghetti, Fiorella, LIVIA BASILE, MATTEO MORI, Garcia-Argaez, Aìda Nelly, AÌDA NELLY GARCIA-ARGAEZ, Basile, Livia, Schwabedissen, Henriette E Meyer Zu, Villa, Stefania   +20 more
core   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Synthesis and antiproliferative activity of novel (+)- usnic acid analogues

, 2019
Twenty one novel (+)- usnic acid-based analogues belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (1H NMR, 13C NMR, IR, and HRMS). The synthesized
Kancharana Balabhaskara Rao (6622172), Nishanth Jain (6622175), Uppuluri Venkata Mallavadhani (5477315), Nagi Reddy Vanga (6622169)   +3 more
core   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Oxadiazoles having antiproliferative activity

, 2003
Oxadiazole derivatives of general formula 1 in which X, Y, R and R2 have the meanings defined in the disclosure. The compounds have antiproliferative activity against a number of human tumors cell lines and can therefore be used for the preparation of ...
Cignarella, Giorgio, Murineddu, Gabriele, Pinna, Gérard Aimé   +2 more
core  

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan-Containing Dipeptide Libraries. [PDF]

J Pept Sci
Reversing the peptide backbone sequence of novel tryptophyl‐dipeptides uncovers profound changes in synthetic accessibility and antineoplastic profiles against human solid tumors. Phenotypic screening identifies a conformationally restricted lead architecture that achieves sub‐micromolar growth inhibition, confirming sequence topology as a critical ...
Díaz JB, Khan AN, González-Bakker A, Padrón JM.   +3 more
europepmc   +2 more sources

Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides

, 2006
The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells.
Jacobsson, Mårten, Mani, Katrin, Ellervik, Ulf, Belting, Mattias   +3 more
core   +1 more source

Design, synthesis and antiproliferative activity of indole analogues of indanocine [PDF]

, 2013
The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines.
Oram, Joseph, Caggiano, Lorenzo, Tunbridge, Gemma A.   +2 more
core   +1 more source