Results 101 to 110 of about 98,967 (297)

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives [PDF]

, 2019
Aim: To develop several new derivatives aimed to complete the studies concerning the antiproliferative profile of the oxadiazole derivative MD77. Materials and Methods: The substitution pattern around the phenyl rings of this compound was analyzed ...
Mori, Matteo, Dalla Via, Lisa, STEFANIA VILLA, Ehrsam, Daniel, Gelain, Arianna, Porta, Fabiola, DANIEL EHRSAM, HENRIETTE E. MEYER ZU SCHWABEDISSEN, ARIANNA GELAIN, FABIOLA PORTA, LISA DALLA VIA, Meyer zu Schwabedissen, Henriette E., FIORELLA MENEGHETTI, Meneghetti, Fiorella, LIVIA BASILE, MATTEO MORI, Garcia-Argaez, Aìda Nelly, AÌDA NELLY GARCIA-ARGAEZ, Basile, Livia, Schwabedissen, Henriette E Meyer Zu, Villa, Stefania   +20 more
core   +1 more source

Anti-proliferative activity of silver nanoparticles

BMC Cell Biology, 2009
Background Nanoparticles possess exceptional physical and chemical properties which led to rapid commercialisation. Silver nanoparticles (Ag-np) are among the most commercialised nanoparticles due to their antimicrobial potential.
Hande M Prakash, AshaRani PV, Valiyaveettil Suresh   +2 more
doaj   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

acyl Thiocarbamates Endowed with Antiproliferative Activity [PDF]

, 2009
In order to further explore the antiproliferative properties of O-phenoxyethyl and O-adamantyl acylthiocarbamates (ATCs), a series of 14 derivs. was prepd. by a parallel adaptation of a highly convergent one-pot three-step procedure.
CESARINI, SARA, Sara Cesarini, SCHENONE, SILVIA, RANISE, ANGELO, Silvia Schenone, Andrea Spallarossa, Angelo Ranise, SPALLAROSSA, ANDREA   +7 more
core   +1 more source

Enhancement of antiproliferative activity by molecular simplification of catalpol

Bioorganic & Medicinal Chemistry, 2010
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed alpha-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86muM.
García, Celina, León, Leticia G., Pungitore, Carlos Rodolfo, Ríos Luci, Carla, Daranas, Antonio H., Montero, Juan C., Pandiella, Atanasio, Tonn, Carlos Eugenio, Martín, Víctor S., Padrón, José M.   +9 more
openaire   +4 more sources

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Optimization of Triterpene Saponins Mixture with Antiproliferative Activity [PDF]

, 2019
In this study, three of the saponins present in leaves of Hedera helix L., α-hederin, hederagenin, and hederacoside C were studied for their antiproliferative activity.
Anca Oancea, Ioan Calinescu, Rodica Tatia, Oana Craciunescu, Lucia Moldovan, Christina Zalaru   +5 more
core   +1 more source

Therapeutic properties of some specific honey types [PDF]

Food and Feed Research
This paper examines the physicochemical characteristics, as well as the antioxidant, antibacterial, and antiproliferative effects, of several honey types that are commercially available but not typical of Serbia.
Sakač Marijana B., Jovanov Pavle, Marić Aleksandar, Plavšić Dragana, Jakimov Dimitar, Đermanović Branislava   +5 more
doaj   +1 more source