Results 1 to 10 of about 186,437 (313)

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

Molecules, 2021
Allium sativum L. (garlic bulbs) and Allium fistulosum L. (Welsh onion leaves) showed quantitative differences of identified compounds: allicin and alliin (380 µg/mL and 1410 µg/mL in garlic; 20 µg/mL and 145 µg/mL in Welsh onion), and the phenolic ...
Adrian Bogdan Țigu, Cristian Silviu Moldovan, Vlad-Alexandru Toma, Anca Daniela Farcaș, Augustin Cătălin Moț, Ancuța Jurj, Eva Fischer-Fodor, Cristina Mircea, Marcel Pârvu   +8 more
doaj   +1 more source

Genomic study and lipidomic bioassay of Leeuwenhoekiella parthenopeia: A novel rare biosphere marine bacterium that inhibits tumor cell viability

Frontiers in Microbiology, 2023
The fraction of low-abundance microbiota in the marine environment is a promising target for discovering new bioactive molecules with pharmaceutical applications.
Giuliano Gattoni, Rafael R. de la Haba, Jesús Martín, Fernando Reyes, Cristina Sánchez-Porro, Antonia Feola, Candida Zuchegna, Shaday Guerrero-Flores, Mario Varcamonti, Ezio Ricca, Nelly Selem-Mojica, Antonio Ventosa, Paulina Corral, Paulina Corral   +13 more
doaj   +1 more source

The antiproliferative potential and mechanism of action of metformin in MCF-7 cells

Future Science OA, 2023
Aim: The current study aimed to investigate the potential antiproliferative activity of metformin, the effective concentration range, and the mechanism of action.
Zhibek Bekezhankyzy, Sholpan Nurzhan, Nurken Berdigaliyev, Shynggys Sergazy, Tilektes Maulenkul, Mohamad Aljofan   +5 more
doaj   +1 more source

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib.
Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Yaser A. Mostafa, Ali E. Raslan, Bahaa G. M. Youssif   +4 more
doaj   +1 more source

Forms and Methods for Interferon’s Encapsulation

Pharmaceutics, 2021
Interferons (IFNs) are cytokines involved in the immune response that act on innate and adaptive immunity. These proteins are natural cell-signaling glycoproteins expressed in response to viral infections, tumors, and biological inducers and constitute ...
Thelvia I. Ramos, Carlos A. Villacis-Aguirre, Nelson Santiago Vispo, Leandro Santiago Padilla, Seidy Pedroso Santana, Natalie C. Parra, Jorge Roberto Toledo Alonso   +6 more
doaj   +1 more source

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne, Falkenburg, J. H. Frederik, Liebermann, Marcus, Nijmeijer, Bart A., Ottmann, Oliver Gerhard, Pfeifer, Heike, Ruthardt, Martin, Tesanovic, Tamara, Wystub, Sylvia   +8 more
core   +6 more sources

Is the Traditional Chinese Herb “Bombax Malabaricum” a Natural Anticancer Medicine?

Journal of Pharmacopuncture, 2022
Cervical spondylotic myelopathy (CSM) is common in elderly people and severe CSM patients are recommended to receive surgery. However, in some cases, surgery may fail to improve the patients’ symptoms.
Siukan Law, Chuiman Lo, Jie Han, Albert Wingnang Leung, Chuanshan Xu   +4 more
doaj   +1 more source

Anticancer Potential of Natural Bark Products—A Review

Plants, 2021
Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved ...
Ema Burlacu, Corneliu Tanase
doaj   +1 more source

A QSAR Study on the 4-Substituted Coumarins as Potent Tubulin Polymerization Inhibitors [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Despite the discovery and synthesis of several anticancer drugs, cancer is still a major life threatening incident for human beings after cardiovascular diseases.
Leila Dinparast, Siavoush Dastmalchi
doaj   +1 more source

(−)-6-epi-Artemisinin, a Natural Stereoisomer of (+)-Artemisinin in the Opposite Enantiomeric Series, from the Endemic Madagascar Plant Saldinia proboscidea, an Atypical Source

Molecules, 2021
Chemical and biological investigation of the Madagascar endemic plant Saldinia proboscidea led to the isolation of an isomer of artemisinin, (−)-6-epi-artemisinin (2). Its structure was elucidated using a combination of NMR and mass spectrometry.
Saholinirina Randrianarivo, Claudine Rasolohery, Sitraka Rafanomezantsoa, Heriniaina Randriamampionona, Liti Haramaty, Roger Marie Rafanomezantsoa, Eric H. Andrianasolo   +6 more
doaj   +1 more source