Results 41 to 50 of about 136,781 (306)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Bioprospection of Tenellins Produced by the Entomopathogenic Fungus Beauveria neobassiana

Journal of Fungi
Fungi are known as prolific producers of bioactive secondary metabolites with applications across various fields, including infectious diseases, as well as in biological control. However, some of the well-known species are still underexplored.
Rita Toshe, Esteban Charria-Girón, Artit Khonsanit, Janet Jennifer Luangsa-ard, Syeda Javariya Khalid, Hedda Schrey, Sherif S. Ebada, Marc Stadler   +7 more
doaj   +1 more source

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

Advanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo, So Yun Lim, Dong‐Sung Won, Ji Won Kim, Yubeen Park, Song Hee Kim, Hyemin Lee, Jung‐Min Ahn, Jun‐Kyu Park, Do‐Yoon Kang, Jung‐Hoon Park   +10 more
wiley   +1 more source

Chemical Characterization of Bioactive Compounds in Extracts and Fractions from Litopenaeus vannamei Muscle

Marine Drugs
Marine organisms are a vital source of biologically active compounds. Organic extracts from the muscle of the Pacific white shrimp (L. vannamei) have shown antiproliferative effects on tumor cells, including breast adenocarcinoma.
Sandra Carolina De La Reé-Rodríguez, María Jesús González, Ingrid Fernández, José Luis Garrido, Erika Silva-Campa, Norma Violeta Parra-Vergara, Carmen María López-Saiz, Isabel Medina   +7 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Salvadora persica leaves: phytochemical profile and in vitro-inhibitory activity on inflammatory mediators implicated in periodontal disease

Pharmaceutical Biology
Context Virtually all parts of Salvadora persica L. (Salvadoraceae) are used in traditional medicine. The twigs and leaves are used for oral health, but leaves are far less investigated.Objective This study assesses the oral health-promoting potential of
Sabine Kobetitsch, Barbara Gierlikowska, Olaf Kunert, Ahmed M.A. Mazen, Pia Raab, Nadine Kretschmer, Carina Donolo, Teresa Pirker, Rudolf Bauer, Anna K. Kiss, Eva-Maria Pferschy-Wenzig   +10 more
doaj   +1 more source

Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita

Molecules, 2016
Natural products, known for their medicinal properties since antiquity, are continuously being studied for their biological properties. In the present study, we analyzed the composition of the volatile preparations of essential oils of the Greek plants ...
Eleni Fitsiou, Gregoria Mitropoulou, Katerina Spyridopoulou, Angeliki Tiptiri-Kourpeti, Manolis Vamvakias, Haido Bardouki, Mihalis Ι. Panayiotidis, Alex Galanis, Yiannis Kourkoutas, Katerina Chlichlia, Aglaia Pappa   +10 more
doaj   +1 more source

In Vitro and In Silico Screening of 2,4,5-Trisubstituted Imidazole Derivatives as Potential Xanthine Oxidase and Acetylcholinesterase Inhibitors, Antioxidant, and Antiproliferative Agents

Applied Sciences, 2020
The employment of privileged scaffolds in medicinal chemistry supplies scientists with a solid start in the search for new and improved therapeutic molecules.
Eduardo Noriega-Iribe, Laura Díaz-Rubio, Arturo Estolano-Cobián, Victor Wagner Barajas-Carrillo, José M. Padrón, Ricardo Salazar-Aranda, Raúl Díaz-Molina, Victor García-González, Rocio Alejandra Chávez-Santoscoy, Daniel Chávez, Iván Córdova-Guerrero   +10 more
doaj   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Antiproliferative Effect of pHLIP-Amanitin

Biochemistry, 2013
Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer ...
Moshnikova, Anna, Moshnikova, Valentina, Andreev, Oleg A., Reshetnyak, Yana   +3 more
openaire   +4 more sources