Results 21 to 30 of about 90,202 (264)

Antiproliferative Effect of Indole Phytoalexins [PDF]

Molecules, 2016
Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant
Martina Chripkova, Frantisek Zigo, Jan Mojzis   +2 more
openaire   +3 more sources

Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

Molecules, 2010
A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds.
Yan-Li Zhao, Qiu-Xia He, Yang Li, Si-Feng Wang, Ke-Chun Liu, Yong-Ping Yang, Xiao-Li Li   +6 more
doaj   +1 more source

Phytochemical Constituents and Antiproliferative Activities of Essential Oils from Four Varieties of Malaysian Zingiber officinale Roscoe against Human Cervical Cancer Cell Line

Plants, 2022
This study evaluates the volatile metabolic constituents and anticancer potential of essential oils distilled from the rhizomes of four Malaysian Zingiber officinale Roscoe (Zingiberaceae family) varieties (Bentong (BE), Cameron Highlands (CH), Sabah (SA)
Atiqah Zaid, Xue Rou Haw, Huda Hisham Alkatib, Sreenivasan Sasidharan, Philip J. Marriott, Yong Foo Wong   +5 more
doaj   +1 more source

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

Molecules, 2009
Staphylea has been used for long time in Traditional Chinese Medicine (TCM) and by Native Americans in a number of therapeutical indications. The present study describes in vitro antiproliferative, cytotoxic properties (MTT and LDH test) and antioxidant ...
Daniel Grancai, Irena Masterova, Jan Muselik, Marianna Jancova, Lubica Lacikova, Maria Fickova   +5 more
doaj   +1 more source

CNL–Clitocybe nebularis Lectin—The Fungal GalNAcβ1-4GlcNAc-Binding Lectin

Molecules, 2019
Clitocybe nebularis lectin (CNL) is present in fruiting bodies of clouded agaric along with several similar isolectins that are all small and stable proteins.
Jerica Sabotič, Janko Kos
doaj   +1 more source

Antiproliferative and Antimicrobial Effects of Rosmarinus officinalis L. Loaded Liposomes

Molecules, 2022
Rosmarinus officinalis L. is a species that is widely known for its culinary and medicinal uses. The purpose of the present study consisted of the evaluation of the antiproliferative and antimicrobial effects of R.
Irina Ielciu, Mihaela Niculae, Emoke Pall, Cristina Barbălată, Ioan Tomuţă, Neli-Kinga Olah, Ramona Flavia Burtescu, Daniela Benedec, Ilioara Oniga, Daniela Hanganu   +9 more
doaj   +1 more source

Phytochemical Composition, Antioxidant and Antiproliferative Activities of Citrus hystrix, Citrus limon, Citrus pyriformis, and Citrus microcarpa Leaf Essential Oils against Human Cervical Cancer Cell Line

Plants, 2022
The essential oil derived from Citrus plants has long been used for medicinal purposes, due to its broad spectrum of therapeutic characteristics. To date, approximately 162 Citrus species have been identified, and many investigational studies have been ...
Haneen Ibrahim Al Othman, Huda Hisham Alkatib, Atiqah Zaid, Sreenivasan Sasidharan, Siti Sarah Fazalul Rahiman, Tien Ping Lee, George Dimitrovski, Jalal T. Althakafy, Yong Foo Wong   +8 more
doaj   +1 more source

Novel 9-Methylanthracene Derivatives as p53 Activators for the Treatment of Glioblastoma Multiforme

Molecules
Glioblastoma multiforme, a highly aggressive and lethal brain tumor, is a substantial clinical challenge and a focus of increasing concern globally. Hematological toxicity and drug resistance of first-line drugs underscore the necessity for new anti ...
Yuxin Feng, Yingjie Wang, Xiaoxue Li, Ziqiang Sun, Sihan Qiang, Hongbo Wang, Yi Liu   +6 more
doaj   +1 more source

New selenosteroids as antiproliferative agents

Organic & Biomolecular Chemistry, 2017
A wide panel of new selenosteroids have been prepared as new antiproliferative agents; improved activities were achieved compared to commonly-used chemotherapeutic agents.
Fuentes-Aguilar, Alma, Romero-Hernández, Laura L., Arenas-González, Ailed, Merino-Montiel, Penélope, Montiel-Smith, Sara, Meza-Reyes, Socorro, Vega-Báez, José Luis, Plata, Gabriela B., Padrón, José M., López, Óscar, Fernández-Bolaños, José G.   +10 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source