Results 121 to 130 of about 155,512 (310)

β-Lapachone analogs with enhanced antiproliferative activity

European Journal of Medicinal Chemistry, 2012
In this study, we describe the synthesis of a series of α- and β-lapachone containing hydroxyl or methoxyl groups on the benzene ring, by means of the selective acid promoted cyclization of the appropriate lapachol analog. The evaluation of the antiproliferative activity in human solid tumor cell lines provided 7-hydroxy-β-lapachone as lead with ...
Ríos Luci, Carla, Bonifazi, Evelyn Lucia, Leon, Leticia G., Montero, Juan C., Burton, Gerardo, Pandiella, Atanasio, Misico, Rosana Isabel, Padron, Jose M.   +7 more
openaire   +4 more sources

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

European Journal of Inorganic Chemistry, EarlyView.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone, Martina Scianna, Isabella Caligiuri, Laura Orian, Pablo Nogara, Nicola Demitri, Flavio Rizzolio, Thomas Scattolin   +7 more
wiley   +1 more source

Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds

Molecules, 2015
There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids ...
Adina-Elena Segneanu, Ioan Grozescu, Florentina Cziple, Daniel Berki, Daniel Damian, Cristina Mariana Niculite, Alexandru Florea, Mircea Leabu   +7 more
doaj   +1 more source

Human adenocarcinoma cell line sensitivity to essential oil phytocomplexes from pistacia species: A multivariate approach [PDF]

, 2017
Principal component analysis (PCA) multivariate analysis was applied to study the cytotoxic activity of essential oils from various species of the Pistacia genus on human tumor cell lines.
Buriani, Alessandro, Carrara, Maria, Dall'Acqua, Stefano, Fortinguerra, Stefano, Gabbia, Daniela, Innocenti, Gabbriella, Montopoli, Monica, Sorrenti, Vincenzo   +7 more
core   +1 more source

Antiproliferative activity of Haematoxylum brasiletto H. Karst

Pharmacognosy Magazine, 2017
Haematoxylum brasiletto is a tree that grows in Central America, commonly known as "Palo de Brasil," which is used in the traditional medicine for the treatment of cancer and gastric ulcers.The aim of this study was to isolate the compounds responsible for antiproliferative activity of H. brasiletto.A bioassay-guided fractionation of ethanol extract of
Bello-Martínez, J, Jiménez-Estrada, M, Rosas-Acevedo, JL, Avila-Caballero, LP, Vidal-Gutierrez, M, Patiño-Morales, C, Ortiz-Sánchez, E, Robles-Zepeda, RE   +7 more
openaire   +3 more sources

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

European Journal of Organic Chemistry, EarlyView.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]

, 2016
α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia, DI SOTTO, Antonella, El Readi, Mahmoud Zaki, Mazzanti, Gabriela, Wink, Michael   +4 more
core  

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Fermentation‐Induced Modulation of Polyphenolic Contents and Medicinal Activities in Annona squamosa Seeds

Food Chemistry International, EarlyView.
The study compared the medicinal activities of polyphenols from fermented and unfermented seeds of Annona squamosa. The polyphenols were extracted and subjected to standard analysis. The major phenolic components of the fermented polyphenols and the unfermented polyphenols were found to be 4‐hydroxybenzoic and 4‐hydroxyphenylacetic acid, respectively ...
Shola Hezekiah Awojide, Abayomi Gideon Adeyemo, Christianah Dare, Oluseye Oladapo Abiona, Adedayo Olubunmi Adeboye, Omolara Oladipo‐Olalekan, Aminat Adebola Adeyemo, Yemisi Elizabeth Asibor, Emmanuel Oluwafemi Adeniyi, Bunmi Regina Bankole, Ezekiel Olumide Fadunmade   +10 more
wiley   +1 more source

Chemical Characterization and Antiproliferative Evaluation of Compounds Isolated from White Shrimp (Penaeus vannamei) By-Products

Biophysica
Cancer is the second leading cause of death worldwide, requiring more effective treatments. By-products from the white shrimp (Penaeus vannamei) are a promising source of bioactive compounds.
Héctor Enrique Trujillo-Ruiz, Dania Guadalupe Leal-Rodríguez, Hisila del Carmen Santacruz-Ortega, Oliviert Martínez-Cruz, Sandra Carolina De La Reé-Rodríguez, Armando Burgos-Hernández, Erika Silva-Campa, Ángel Antonio Carbonell-Barrachina, Carmen María López-Saiz   +8 more
doaj   +1 more source