Results 111 to 120 of about 6,141,319 (295)

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

open access: yesChemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi   +6 more
wiley   +1 more source

Characterization of antiradical and antiproliferative activity of flavonoid’s synthetic analogs

open access: yes, 2011
New flavonoid’ s synthetic analogs were obtained. Their antiradical and antiproliferative activity was characterized by decolorizating method using ABTS ’+ and by means of MTT ...
Oreshko, N.A.   +5 more
core  

Azoimidazolium Salts as a Platform for Persistent Neutral Aminyl Radicals and Mesoionic Carbene Au(I) Complexes as Cell‐Permeable Fluorophores

open access: yesChemistry – A European Journal, EarlyView.
Strategic electronic matching between imidazolium salts and aryldiazonium salts enables a chromatography‐free route to versatile azoimidazolium scaffolds. Fine‐tuning the substituents unveils a powerful dichotomy: strong ─OMe resonance stabilizes highly persistent neutral aminyl radicals (up to 3 weeks), whereas the superior ─NMe2 donor strength yields
Diego Dusso   +6 more
wiley   +1 more source

Antiproliferative Activity of Natural Taiwaniaquinoids and Related Compounds

open access: yes, 2017
The in vitro antiproliferative activities of some taiwaniaquinoids and related compounds with functionalized A, B, or C rings against human breast (MCF-7), colon (T-84), and lung (A-549) tumor cell lines were assayed.
Juan J. Guardia (2130502)   +6 more
core   +1 more source

Design and synthesis of novel oridonin analogues as potent anticancer agents

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2018
To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties.
Qing-Kun Shen   +6 more
doaj   +1 more source

The Serendipitous Discovery of Rollover Cyclometalation: From Unrecognized Observation to Transformative Chemistry

open access: yesEuropean Journal of Inorganic Chemistry, EarlyView.
Rollover cyclometalation is a distinctive variant of classical cyclometalation where a chelated heterocyclic ligand undergoes internal rotation, releasing one donor atom from coordination and subsequently activating a remote C─H bond with high regioselectivity.
Antonio Zucca, Maria I. Pilo
wiley   +1 more source

Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

open access: yes, 2018
Sixteen flavonoid triazolyl glycosides 4–19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1–3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous ...
Gang-qiang Wang, Qiu-an Wang, Li-li Yan
core   +1 more source

Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds

open access: yesMolecules, 2015
There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids ...
Adina-Elena Segneanu   +7 more
doaj   +1 more source

Optimising the Eco‐Friendly Extraction of Carotenoids From Gac Fruit: A Sustainable Solution for Natural Red Food Colourants

open access: yesFood Chemistry International, EarlyView.
Gac fruit's high carotenoid content, especially in the aril, makes it an excellent natural red pigment source for food applications, offering a safer alternative to synthetic dyes. Ethanol extraction achieved the highest overall pigment recovery (89.53%), whereas ethyl lactate extraction yielded the highest levels of total carotenoids, β‐carotene ...
N. Netravati   +4 more
wiley   +1 more source

Chemical Characterization and Antiproliferative Evaluation of Compounds Isolated from White Shrimp (Penaeus vannamei) By-Products

open access: yesBiophysica
Cancer is the second leading cause of death worldwide, requiring more effective treatments. By-products from the white shrimp (Penaeus vannamei) are a promising source of bioactive compounds.
Héctor Enrique Trujillo-Ruiz   +8 more
doaj   +1 more source

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