Results 111 to 120 of about 98,614 (298)

Photoswitching off the Antiproliferative Activity of Combretastatin A‑4 Analogues

, 2019
The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results ...
Igor V. Zavarzin (1478929), Valerii Z. Shirinian (1478923), Ashot I. Markosyan (3383867), Anton V. Yadykov (7854404), Victoria V. Trofimova (7854407), Alexander M. Scherbakov (6691031), Andrey G. Lvov (3383861)   +6 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum

Marine Drugs, 2016
Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3–9), were isolated from the deep-sea-derived fungus Chaetomium globosum.
Zhihan Zhang, Xitian Min, Junjun Huang, Yue Zhong, Yuehua Wu, Xiaoxia Li, Yinyue Deng, Zide Jiang, Zongze Shao, Lianhui Zhang, Fei He   +10 more
doaj   +1 more source

Oxadiazoles having antiproliferative activity

, 2003
Oxadiazole derivatives of general formula 1 in which X, Y, R and R2 have the meanings defined in the disclosure. The compounds have antiproliferative activity against a number of human tumors cell lines and can therefore be used for the preparation of ...
Cignarella, Giorgio, Murineddu, Gabriele, Pinna, Gérard Aimé   +2 more
core  

Microbial Transformations of Halolactones and Evaluation of Their Antiproliferative Activity

, 2023
The microbial transformations of lactones with a halogenoethylocyclohexane moiety were performed in a filamentous fungi culture. The selected, effective biocatalyst for this process was the Absidia glauca AM177 strain.
Bożena Obmińska-Mrukowicz, Karolina Maria Zych, Aleksandra Pawlak, Marcelina Mazur   +3 more
core   +1 more source

Advances in Chitosan Nanoparticles: A Comprehensive Review of Properties, Synthesis, Characterization, Multidisciplinary Applications, and Future Perspectives

Journal of Applied Polymer Science, EarlyView.
This review highlights the synthesis of chitosan nanoparticles from natural sources, the thorough characterization of them, and use of microscopic and spectroscopic methods. It emphasizes that it has some indispensable properties such as being non‐toxic, antimicrobial, and capable of controlled drug release.
Mariam Sohail Mansoor, Nayab Raza, Furqana Bibi, Madiha Mumtaz, Asif Abbas, Farasat Haider, Basit Ali   +6 more
wiley   +1 more source

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line.
Guangcheng Wang, Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li, Zhiyun Peng   +5 more
doaj   +1 more source

Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

, 2018
Sixteen flavonoid triazolyl glycosides 4–19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1–3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous ...
Gang-qiang Wang, Qiu-an Wang, Li-li Yan
core   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source

Antimicrobial property and antiproliferative activity of Centaurea babylonica (L.) L. on human carcinomas and cervical cancer cell lines

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective Since antiquity, C. babylonica (L.) L. extracts has been used as a remedy for primary health care in traditional medicine.
Nur Ceyhan Güvensen, Dilek Keskin, Hatice Güneş, Müjgan Kesik Oktay, Hasan Yıldırım   +4 more
doaj   +1 more source