Results 111 to 120 of about 5,874,294 (289)

Photoswitching off the Antiproliferative Activity of Combretastatin A‑4 Analogues

, 2019
The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results ...
Igor V. Zavarzin (1478929), Valerii Z. Shirinian (1478923), Ashot I. Markosyan (3383867), Anton V. Yadykov (7854404), Victoria V. Trofimova (7854407), Alexander M. Scherbakov (6691031), Andrey G. Lvov (3383861)   +6 more
core   +1 more source

Enhancement of antiproliferative activity by molecular simplification of catalpol

Bioorganic & Medicinal Chemistry, 2010
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed alpha-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86muM.
García, Celina, León, Leticia G., Pungitore, Carlos Rodolfo, Ríos Luci, Carla, Daranas, Antonio H., Montero, Juan C., Pandiella, Atanasio, Tonn, Carlos Eugenio, Martín, Víctor S., Padrón, José M.   +9 more
openaire   +4 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

The Structure–Antiproliferative Activity Relationship of Pyridine Derivatives

Pyridine, a compound with a heterocyclic structure, is a key player in medicinal chemistry and drug design. It is widely used as a framework for the design of biologically active molecules and is the second most common heterocycle in FDA-approved drugs ...
Mayra Lizett González-Félix, Milagros Aguilar-Martínez, Manuel G. Ballesteros-Monreal, Juan-Carlos Gálvez-Ruiz, Ana-Laura Villa-Reyna, Dora Valencia, Mario-Alberto Leyva-Peralta, Dulce María Gonzalez-Mosquera, Martin Perez-Velazquez   +8 more
core   +1 more source

Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

, 2018
Sixteen flavonoid triazolyl glycosides 4–19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1–3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous ...
Gang-qiang Wang, Qiu-an Wang, Li-li Yan
core   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Final 2‐Year Results of the REFORM Study: A Randomized Trial of Biolimus DCB Versus Paclitaxel DCB for In‐Stent Restenosis

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background In the REFORM trial, treatment of coronary in‐stent restenosis with a Biolimus A9™ drug‐coated balloon (BCB) was found to be inferior with respect to in‐segment percentage stenosis at 6‐months in comparison to treatment with a standard paclitaxel coated paclitaxel‐coated balloon (PCB). Aims In this manuscript, the final prespecified
Daniel O'Callaghan, J. J. Coughlan, Fernando Alfonso, Joo‐Yong Hahn, Manel Sabate, Ralph Toelg, Samuel Copt, Sean Fitzgerald, Marie‐Claude Morice, Jasper Trevelyan, Darren Mylotte, Antonio Fernandez Ortiz, Rory Durand, Jochen Wöhrle, Franz Xever Kleber, Giuilo Stefanini, Himanshu Rai, Peter O'Kane, Robert A. Byrne   +18 more
wiley   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Modular Synthesis of Di‐ and Triazadibenzoazulenes by a Cross‐Coupling/Cycloisomerization Strategy

European Journal of Organic Chemistry, EarlyView.
Two series of regioisomeric di‐ and triazadibenzoazulenes were prepared from dihalogenated imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines. Imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines are important nitrogen‐containing heterocycles with applications in medicinal and materials chemistry.
Karyna Kulyk, Artyom Petrosyan, Karsten Paul Lüdtke, Jonas Surkau, Martin Köckerling, Peter Ehlers, Peter Langer   +6 more
wiley   +1 more source