Results 91 to 100 of about 98,614 (298)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Anti-proliferative activity of silver nanoparticles

BMC Cell Biology, 2009
Background Nanoparticles possess exceptional physical and chemical properties which led to rapid commercialisation. Silver nanoparticles (Ag-np) are among the most commercialised nanoparticles due to their antimicrobial potential.
Hande M Prakash, AshaRani PV, Valiyaveettil Suresh   +2 more
doaj   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells

Molecules, 2011
Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The
Héctor Carrasco Altamirano, Joan Villena García, Luis Espinoza Catalán, Iván Montenegro Venegas, Alejandro Madrid Villegas   +4 more
doaj   +1 more source

Substituted adamantylphthalimides: Synthesis, antiviral and antiproliferative activity

Archiv der Pharmazie, 2020
AbstractIn this study, three groups of adamantylphthalimides, bearing different substituents at the phthalimide moiety, N‐(4′‐R2)phthalimidoadamantanes (1–7), 3‐[N‐(4′‐R2)phthalimido]‐1‐adamantanols (8–10), and 3‐[N‐(4′‐R2)phthalimido]adamantane‐1‐carboxylic acids (11–15), were synthesized and screened against tumor cells and viruses.
Mandic, Leo, Bencic, Patricia, Mlinaric-Majerski, Kata, Liekens, Sandra, Snoeck, Robert, Andrei, Graciela, Kralj, Marijeta, Basaric, Nikola   +7 more
openaire   +3 more sources

Antiproliferative activity of terpene-phospholipids against selected cell lines.

, 2016
Antiproliferative activity of terpene-phospholipids against selected cell lines.
Anna Gliszczyńska (2839163), Witold Gładkowski (2839157), Marta Czarnecka (2839154), Marta Świtalska (2141767), Natalia Niezgoda (2839160), Joanna Wietrzyk (534260)   +5 more
core   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Analysis and Biological Evaluation of Arisaema Amuremse Maxim Essential Oil

Open Chemistry, 2019
The chemical composition and antitumor activity of essential oil were compared for four parts of the Arisaema Amuremse Maxim. Chemical constituent of essential oil in every parts of Arisaema Amuremse Maxim was identified by GC-MS analysis systematically.
Li Guiying, Jiang Yueyao, Li Yingjun, He Tong, Wang Ying, Ji Tianyi, Zhai Wanchen, Zhao Lichun, Zhou Xiaoping   +8 more
doaj   +1 more source

Synthesis and antiproliferative activity of 6-phenylaminopurines

European Journal of Medicinal Chemistry, 2014
A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative ...
María-Dolores Canela, Sandra Liekens, María-José Camarasa, Eva María Priego, María-Jesús Pérez-Pérez   +4 more
openaire   +3 more sources

Antiproliferative and antibacterial activity evaluation of red microalgae Rhodosorus marinus

, 2015
Antiproliferative activity of three extracts obtained from red microalgae Rhodosorus marinus was evaluated against cervical (HeLa), colon (HCT 116), lung (A549), prostate (22Rv-1) and breast (HCC38 and MDA-MB-231) cancer cell lines.
Gutierrez-Millan, LE, Lopez-Torres, MA, Zazueta, MGB, Valdez, MA, Acedo-Felix, E, Garcia-Galaz, A, Burgos-Hernandez, A   +6 more
core   +1 more source