Results 91 to 100 of about 155,512 (310)

Antiproliferative activity of arborescidine alkaloids and derivatives

European Journal of Medicinal Chemistry, 2009
Current issues in cancer research involve searching for novel anticancer compounds that can be used to regulate the cell cycle and lead to more effective treatments of tumors. In this study, it was hypothesized that possessing a cyclic alkaloid similar to harmine, arborescidines can disrupt the proliferative state of cancer cells and block the activity
Santos, Leonardo S., Theoduloz, Cristina, Pilli, Ronaldo A., Rodriguez, Jaime   +3 more
openaire   +6 more sources

Optimized synthesis and antiproliferative activity of desTHPdactylolides [PDF]

Bioorganic & Medicinal Chemistry, 2018
Dactylolide and certain analogues are attractive targets for study due to their structural resemblance to zampanolide, a very promising anticancer lead compound and a unique covalent-binding microtubule stabilizing agent. The primary goal of this project is identification and synthesis of simplified analogues of dactylolide that would be easier to ...
Guanglin, Chen, Rubing, Wang, Bao, Vue, Manee, Patanapongpibul, Qiang, Zhang, Shilong, Zheng, Guangdi, Wang, James D, White, Qiao-Hong, Chen   +8 more
openaire   +2 more sources

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Studies of the antitumor mechanism of action of dermaseptin B2, a multifunctional cationic antimicrobial peptide, reveal a partial implication of cell surface glycosaminoglycans.

PLoS ONE, 2017
Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo.
Célia Dos Santos, Sabah Hamadat, Karen Le Saux, Clara Newton, Meriem Mazouni, Loussiné Zargarian, Mickael Miro-Padovani, Patricia Zadigue, Jean Delbé, Yamina Hamma-Kourbali, Mohamed Amiche   +10 more
doaj   +1 more source

Yeast-derived biosynthesis of silver/silver chloride nanoparticles and their antiproliferative activity against bacteria [PDF]

, 2016
Here, we provide the first evidence of yeast strains assisted Ag/AgCl-NPs production in vitro. The formed nanoparticles were characterized by spectroscopic and electron microscopy approaches. UV-vis supported the biosynthesis. TEM analysis evidenced that
Almeida-Paes, Rodrigo, de Souza, Wanderley, Eugenio, Mateus, Farina, Marcos, Frasés, Susana, Lemgruber, Leandro, Lima, Luís Maurício T.R., Müller, Nathalia, Sant'Anna, Celso   +8 more
core   +1 more source

Antiproliferative activity of Vallaris glabra Kuntze (Apocynaceae)

Pharmacognosy Magazine, 2014
Our earlier study on the antiproliferative (APF) activity of leaf extracts of ten Apocynaceae species showed that leaves of Vallaris glabra possessed strong and broad-spectrum properties.In this study, sequential extracts of leaves, flowers and stems, and fractions and isolated compounds from dichloromethane (DCM) leaf extract of V.
Wong, Siu Kuin, Lim, Yau Yan, Ling, Sui Kiong, Chiang Chan, Eric Wei   +3 more
openaire   +3 more sources

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Analysis and Biological Evaluation of Arisaema Amuremse Maxim Essential Oil

Open Chemistry, 2019
The chemical composition and antitumor activity of essential oil were compared for four parts of the Arisaema Amuremse Maxim. Chemical constituent of essential oil in every parts of Arisaema Amuremse Maxim was identified by GC-MS analysis systematically.
Li Guiying, Jiang Yueyao, Li Yingjun, He Tong, Wang Ying, Ji Tianyi, Zhai Wanchen, Zhao Lichun, Zhou Xiaoping   +8 more
doaj   +1 more source

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source