Results 71 to 80 of about 6,141,319 (295)
Angewandte Chemie, EarlyView.Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo +7 more
wiley +2 more sources
Top-ranked compounds (hits) with high confidence antiproliferative activity in MTT PHEO cells.
, 2014 Top-ranked compounds (hits) with high confidence antiproliferative activity in MTT PHEO cells.
Karel Pacak (63357) +11 more
core +1 more source
Antiproliferative Activity of Aminobenzylnaphthols Deriving from the Betti Reaction [PDF]
, 2022 Two aminobenzylnaphthols, which are representative items of the family of compounds synthesized with the Betti reaction, were investigated as antiproliferative agents against adenocarcinoma human colorectal (Caco-2) and human neuroblastoma (SH-SY5Y) cell
Cardellicchio, Cosimo +6 more
core +1 more source
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity
, 2022 Although various dual-target tubulin inhibitors have been designed and synthesised, no dual tubulin-NEDDylation inhibitors as antiproliferative agents were reported so far.
Fu, Dong-Jun +3 more
core +2 more sources
Molecules, 2012 The antiproliferative and antimicrobial effects of thirteen compounds isolated from Inula viscosa (L.) were tested in this study. The antiproliferative activity was tested against three cell lines using the MTT assay. The microdilution method was used to
Wamidh H. Talib +2 more
doaj +1 more source
Applied Sciences, 2022 The phytochemical compositions of green coffee beans (GB), roasted coffee (RC), and the solid residue known as spent coffee grounds (SCG) have been associated with beneficial physiological effects.
Gema C. Díaz-Hernández +7 more
doaj +1 more source
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
, 2017 Antiproliferative activity of isoprenoid-phospholipid conjugates against human leukemia MV4-11 cell line.
Anna Gliszczyńska (2839163) +4 more
core +1 more source