Results 51 to 60 of about 98,614 (298)

Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core

, 2014
A series of novel hexa-arm star shaped thiosemicarbazones with different substitutions at para positions emanating from cyclotriphosphazene core were prepared with excellent yields.
Patil, B.R., Machakanur, S.S., Bakale, R.P., Naik, G.N., Bligh, S.W.A., Gudasi, K.B.   +5 more
core   +1 more source

Antioxidative, Antibacterial and Antiproliferative Properties of Honey Types from the Western Balkans

Antioxidants, 2022
This paper presents the physicochemical characteristics and antioxidative, antibacterial and antiproliferative effects of nineteen samples of different honey types (acacia, linden, heather, sunflower, phacelia, basil, anise, sage, chestnut, hawthorn ...
Marijana Sakač, Pavle Jovanov, Aleksandar Marić, Dragana Četojević-Simin, Aleksandra Novaković, Dragana Plavšić, Dubravka Škrobot, Renata Kovač   +7 more
doaj   +1 more source

Optimized synthesis and antiproliferative activity of desTHPdactylolides [PDF]

Bioorganic & Medicinal Chemistry, 2018
Dactylolide and certain analogues are attractive targets for study due to their structural resemblance to zampanolide, a very promising anticancer lead compound and a unique covalent-binding microtubule stabilizing agent. The primary goal of this project is identification and synthesis of simplified analogues of dactylolide that would be easier to ...
Guanglin, Chen, Rubing, Wang, Bao, Vue, Manee, Patanapongpibul, Qiang, Zhang, Shilong, Zheng, Guangdi, Wang, James D, White, Qiao-Hong, Chen   +8 more
openaire   +2 more sources

The Tumor Cell Proliferation Inhibitory Activity of the Human Herpes Virus Type 6 U94 Protein Relies on a Stable Tridimensional Conformation

Microorganisms
The U94 protein of Human Herpesvirus 6 exerts antiproliferative effects through downregulation of the Src proto-oncogene. We aimed to define the shortest U94 fragment that preserves antiproliferative activity and to explore its structural properties. U94
Anna Bertelli, Matteo Uggeri, Federica Filippini, Melissa Duheric, Francesca Caccuri, Arnaldo Caruso   +5 more
doaj   +1 more source

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity

Chemistry Central Journal, 2012
Background Cancer is one of the most dreaded diseases and it is a leading cause of mankind death worldwide. Recent reports documented a remarkable antiproliferative activity of isatin nucleus against various cancer cell lines.
Aboul-Fadl Tarek, Radwan Awwad A, Attia Mohamed I, Al-Dhfyan Abdullah, Abdel-Aziz Hatem A   +4 more
doaj   +1 more source

Antiproliferative Activity of IL-27 on Melanoma [PDF]

The Journal of Immunology, 2008
Abstract IL-27 is a member of the IL-6/IL-12 family and activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130. We previously demonstrated that IL-27 has potent antitumor activities, which are mediated through CD8+ T cells, NK cells, or its own antiangiogenic activity. In this study, we demonstrate that
Takayuki, Yoshimoto, Noriko, Morishima, Izuru, Mizoguchi, Motomu, Shimizu, Hiroshi, Nagai, Shuntaro, Oniki, Masahiro, Oka, Chikako, Nishigori, Junichiro, Mizuguchi   +8 more
openaire   +2 more sources

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

Molecules, 2014
A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones 2a–n.
Abdulrahman I. Almansour, Raju Suresh Kumar, Farzana Beevi, Amir Nasrolahi Shirazi, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Brian Sullivan, Kellen McCaffrey, Alaa Nahhas, Keykavous Parang, Mohamed Ashraf Ali   +11 more
doaj   +1 more source

Antiproliferative activities of alkaloid-like compounds

MedChemComm, 2017
Tricyclic alkaloid-like compounds were synthesised in a few steps, via the bridging Ritter reaction.
XiXi Xu, Tristan Rawling, Ariane Roseblade, Roger Bishop, Alison T. Ung   +4 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

BMC Complementary and Alternative Medicine, 2013
Background The aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri ...
Jiménez-Estrada Manuel, Velázquez-Contreras Carlos, Garibay-Escobar Adriana, Sierras-Canchola Davisela, Lapizco-Vázquez Ricardo, Ortiz-Sandoval Carolina, Burgos-Hernández Armando, Robles-Zepeda Ramón Enrique   +7 more
doaj   +1 more source