Results 51 to 60 of about 6,141,319 (295)

Synthesis and <i>in vitro</i> antiproliferative activity of dolutegravir derivatives against hepatocellular carcinoma <i>via</i> apoptosis-related mechanisms. [PDF]

RSC Adv
Dolutegravir derivatives bearing 1,2,3-triazole moieties 3b and 3i exhibited potent antiproliferative activity against HepG2 cells.
Hou X, Huang M, Zhang Q, Yao Q, Yang J.
europepmc   +2 more sources

Optimized synthesis and antiproliferative activity of desTHPdactylolides [PDF]

Bioorganic & Medicinal Chemistry, 2018
Dactylolide and certain analogues are attractive targets for study due to their structural resemblance to zampanolide, a very promising anticancer lead compound and a unique covalent-binding microtubule stabilizing agent. The primary goal of this project is identification and synthesis of simplified analogues of dactylolide that would be easier to ...
Guanglin, Chen, Rubing, Wang, Bao, Vue, Manee, Patanapongpibul, Qiang, Zhang, Shilong, Zheng, Guangdi, Wang, James D, White, Qiao-Hong, Chen   +8 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Antiproliferative Activity of IL-27 on Melanoma [PDF]

The Journal of Immunology, 2008
Abstract IL-27 is a member of the IL-6/IL-12 family and activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130. We previously demonstrated that IL-27 has potent antitumor activities, which are mediated through CD8+ T cells, NK cells, or its own antiangiogenic activity. In this study, we demonstrate that
Takayuki, Yoshimoto, Noriko, Morishima, Izuru, Mizoguchi, Motomu, Shimizu, Hiroshi, Nagai, Shuntaro, Oniki, Masahiro, Oka, Chikako, Nishigori, Junichiro, Mizuguchi   +8 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

BMC Complementary and Alternative Medicine, 2013
Background The aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri ...
Jiménez-Estrada Manuel, Velázquez-Contreras Carlos, Garibay-Escobar Adriana, Sierras-Canchola Davisela, Lapizco-Vázquez Ricardo, Ortiz-Sandoval Carolina, Burgos-Hernández Armando, Robles-Zepeda Ramón Enrique   +7 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Antiproliferative and antibacterial activity evaluation of red microalgae Rhodosorus marinus [PDF]

, 2015
Antiproliferative activity of three extracts obtained from red microalgae Rhodosorus marinus was evaluated against cervical (HeLa), colon (HCT 116), lung (A549), prostate (22Rv-1) and breast (HCC38 and MDA-MB-231) cancer cell lines.
Gutierrez-Millan, LE, Lopez-Torres, MA, Zazueta, MGB, Valdez, MA, Acedo-Felix, E, Garcia-Galaz, A, Burgos-Hernandez, A   +6 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Synthetic Derivatives of Vinpocetine as Antiproliferative Agents

Drugs and Drug Candidates
Background/Objectives: Vincamine is an indole alkaloid initially isolated from plants of the Vinca genus and has previously been demonstrated to have antioxidant, hypoglycemic, and hypolipidemic activities.
Mihira Gutti, Melanie Tsui, Stella Yang, Selina Xi, Jennifer Luo, Arshia Desarkar, Yining Xie, Mirabelle Feng, Udbhav Avadhani, Shloka Raghavan, Elena Brierley-Green, Erika Yu, Edward Njoo   +12 more
doaj   +1 more source