Results 41 to 50 of about 155,512 (310)

Preclinical efficacy of [V 4 Q 5 ]dDAVP, a second generation vasopressin analog, on metastatic spread and tumor-associated angiogenesis in colorectal cancer [PDF]

, 2018
Purpose Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V 4 Q 5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors.
Alonso, Daniel Fernando, Garona, Juan, Gomez, Daniel Eduardo, Pifano, Marina, Ripoll, Giselle Vanina, Segatori, Valeria Inés, Sobol, Natasha Tatiana   +6 more
core   +1 more source

Antiproliferative activity of semisynthetic xylopic acid derivatives

Natural Product Research, 2021
Two ent-kaurene diterpenoids, ent-15-β-acetyloxy-kaur-16-en-19-oic acid (xylopic acid) 1 and ent-7-oxo-kaur-16-en-19-oic acid 2 were isolated from the fruits of Xylopia aethiopica. Chemical manipulation of xylopic acid yielded ent-kaurane derivatives 3, 4, 5, and 6.
Désiré Soh, Nkwengoua Ernestine, Emmanuella Marthe Tchana Satchet, Ulrich Dzo Defokou, Bernd Schneider, Vidari Giovanni, Barthélemy Nyassé   +6 more
openaire   +4 more sources

The antiproliferative potential and mechanism of action of metformin in MCF-7 cells

Future Science OA, 2023
Aim: The current study aimed to investigate the potential antiproliferative activity of metformin, the effective concentration range, and the mechanism of action.
Zhibek Bekezhankyzy, Sholpan Nurzhan, Nurken Berdigaliyev, Shynggys Sergazy, Tilektes Maulenkul, Mohamad Aljofan   +5 more
doaj   +1 more source

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]

, 2017
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da, Bernardi, A, Colombo, G. 1., D'Annessa, I, Moroni, E, Pennati, M, Rasola, Andrea, SANCHEZ MARTIN, Carlos, Sattin, S, Tao, J, Zaffaroni, N   +10 more
core   +1 more source

Antiproliferative Activity of -Oxacassanes from

Natural Product Communications, 2015
This work reports the antiproliferative activity of seco -oxacassanes 1–3 , isolated from Acacia schaffneri , against human colon (HT-29), lung (A-549), and melanoma (UACC-62) cancer cell lines, as well as against their non-malignant counterparts CCD-841
J. Martín Torres-Valencia, Virginia Motilva, J. Jesús Manríquez-Torres, Sofía García-Mauriño, Miguel López-Lázaro, Hanaa Zbakh, José M. Calderón-Montaño, Mario A. Gómez-Hurtado, Juan A. Gayosso-De-Lucio, Carlos M. Cerda-García-Rojas, Pedro Joseph-Nathan   +10 more
doaj   +1 more source

Antiproliferative, antimicrobial, and antioxidant activity of Lavandula angustifolia Mill. essential oil

Journal of Health Sciences, 2017
Introduction: We studied the chemical composition and antimicrobial, antioxidant, and antiproliferative activities of essential oils from flowers of Lavandula angustifolia grown in Southern Bosnia and Herzegovina.
Haris Niksic, Elvira Kovac-Besovic, Elma Omeragic, Samija Muratovic, Jasna Kusturica, Kemal Duric   +5 more
doaj   +1 more source

Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells [PDF]

, 2010
Indexación: ScieloSafrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure.
Carrasco Altamirano, Héctor, Cuellar Fritis, Mauricio, Espinoza Catalán, Luis, Madrid Villegas, Alejandro, Taborga Liber, Lautaro, Villena García, Joan   +5 more
core   +2 more sources

Antioxidative, Antibacterial and Antiproliferative Properties of Honey Types from the Western Balkans

Antioxidants, 2022
This paper presents the physicochemical characteristics and antioxidative, antibacterial and antiproliferative effects of nineteen samples of different honey types (acacia, linden, heather, sunflower, phacelia, basil, anise, sage, chestnut, hawthorn ...
Marijana Sakač, Pavle Jovanov, Aleksandar Marić, Dragana Četojević-Simin, Aleksandra Novaković, Dragana Plavšić, Dubravka Škrobot, Renata Kovač   +7 more
doaj   +1 more source

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines [PDF]

, 2017
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia.
Cabrera, Maia Diana Eliana, Cardama, Georgina Alexandra, Davio, Carlos Alberto, Echeverría, Emiliana Beatriz, Fernandez, Natalia Cristina, González, Nazareno, Lorenzano Menna, Pablo, Remes Lenicov, Federico   +7 more
core   +2 more sources

The Tumor Cell Proliferation Inhibitory Activity of the Human Herpes Virus Type 6 U94 Protein Relies on a Stable Tridimensional Conformation

Microorganisms
The U94 protein of Human Herpesvirus 6 exerts antiproliferative effects through downregulation of the Src proto-oncogene. We aimed to define the shortest U94 fragment that preserves antiproliferative activity and to explore its structural properties. U94
Anna Bertelli, Matteo Uggeri, Federica Filippini, Melissa Duheric, Francesca Caccuri, Arnaldo Caruso   +5 more
doaj   +1 more source