Results 41 to 50 of about 5,874,294 (289)

Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity

, 2022
Although various dual-target tubulin inhibitors have been designed and synthesised, no dual tubulin-NEDDylation inhibitors as antiproliferative agents were reported so far.
Fu, Dong-Jun, Wang, Ting, Ting Wang, Dong-Jun Fu   +3 more
core   +2 more sources

Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of ‘Ataulfo’ Mango Peel on LS180 Cells

Molecules, 2018
Mango “Ataulfo” peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP’s antioxidant activity.
Gustavo. R. Velderrain-Rodríguez, Heriberto Torres-Moreno, Mónica A. Villegas-Ochoa, J. Fernando Ayala-Zavala, Ramón E. Robles-Zepeda, Abraham Wall-Medrano, Gustavo A. González-Aguilar   +6 more
doaj   +1 more source

The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

Food Science and Human Wellness, 2023
Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition
Ningxuan Gao, Xu Si, Wenzhong Han, Ersheng Gong, Chi Shu, Jinlong Tian, Yuehua Wang, Jiyue Zhang, Binxu Li, Bin Li   +9 more
doaj   +1 more source

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Cumhuriyet Science Journal, 2022
In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of ...
Murat Doğan, Mizgin Ermanoğlu, Turan Arabaci, Duygu Taşkın   +3 more
doaj   +1 more source

Antiproliferative Effect of Methanolic Extract of Linum arboreum on A549 Cells

Proceedings, 2017
Many anticancer drugs in clinical use are natural product derived from natural sources. Today, investigations of anti cancer effect of different natural products are increase.
Ozgur Vatan, Ozer Yılmaz, Huzeyfe Huriyet, Tolga Cavas, Nilufer Cinkılıç   +4 more
doaj   +1 more source

ANTIPROLIFERATIVE ACTIVITY OF BERBERINE IN VITRO AND IN VIVO [PDF]

Biomedical Papers, 2005
Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg.
Silvia, Letasiová, Sona, Jantová, Marta, Múcková, Marica, Theiszová   +3 more
openaire   +2 more sources

Antiproliferative activities of alkaloid-like compounds

MedChemComm, 2017
Tricyclic alkaloid-like compounds were synthesised in a few steps, via the bridging Ritter reaction.
XiXi Xu, Tristan Rawling, Ariane Roseblade, Roger Bishop, Alison T. Ung   +4 more
openaire   +3 more sources

Synthesis and Antiproliferative Activities of Ottelione A Analogues [PDF]

ACS Medicinal Chemistry Letters, 2012
Through the syntheses of its C-1 desvinyl, C-7 methylene, C-7 exocyclic ethylidene, and various C-3 phenylmethyl analogues, the structure-activity relationship of antimitotic ottelione A (4) against tubulin and various cancer cells was established. The results indicated that compound 4 was a colchicine-competitive inhibitor and that the C-1 vinyl group
Tsai-Yuan, Chang, Yun-Peng, Tu, Win-Yin, Wei, Hsiang Yu, Chen, Chih-Shang, Chen, Ying-Shuan E, Lee, Jiann-Jyh, Huang, Chin-Kang, Sha   +7 more
openaire   +2 more sources

Targeting EGFR by newer 4,6-Bis((E)-4-hydroxy-3-methoxystyryl)-1-(aryl)pyrimidin-2(1H)-one analogues as antiproliferative agents: eco-friendly chemical modification, in-vitro and in-silico studies

Journal of Taibah University for Science
We reported herein the synthesis, antiproliferative activity and in-silico studies of semi-synthetic curcumin analogues. An equimolar amount of curcumin (A1) and mono aryl urea (B01–B04) were heated in a glycerol-water (1:2, v/v) solvent system at 80°C ...
Md. Faiyaz Ahsan, Mohamed Jawed Ahsan, Mohammad Yusuf, S. Tasqeeruddin, Yahya I. Asiri, Amena Ali, S. Salahuddin   +6 more
doaj   +1 more source

Antiproliferative Activity of -Oxacassanes from

Natural Product Communications, 2015
This work reports the antiproliferative activity of seco -oxacassanes 1–3 , isolated from Acacia schaffneri , against human colon (HT-29), lung (A-549), and melanoma (UACC-62) cancer cell lines, as well as against their non-malignant counterparts CCD-841
J. Martín Torres-Valencia, Virginia Motilva, J. Jesús Manríquez-Torres, Sofía García-Mauriño, Miguel López-Lázaro, Hanaa Zbakh, José M. Calderón-Montaño, Mario A. Gómez-Hurtado, Juan A. Gayosso-De-Lucio, Carlos M. Cerda-García-Rojas, Pedro Joseph-Nathan   +10 more
doaj   +1 more source