Results 31 to 40 of about 155,512 (310)

Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents [PDF]

, 2016
A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 ...
Chandra, Narendra Sharath JN, Kolli, Swetha, Paturi, Manichandrika, Ravula, Parameshwar, Vamaraju, Harinadha Babu   +4 more
core   +1 more source

Backbone modified TBA analogues endowed with antiproliferative activity [PDF]

, 2017
Background: Thrombin binding aptamer (TBA) is endowed with antiproliferative properties but its potential development is counteracted by concomitant anticoagulant activity. Methods: Five oligonucleotides (ODNs) based on TBA sequence (GGTTGGTGTGGTTGG) and
AMATO, TERESA, BUCCI, MARIAROSARIA, ESPOSITO, VERONICA, GALEONE, ALDO, RUSSO, ANNAPINA, RUSSO, GIULIA, VARRA, MICHELA, VELLECCO, VALENTINA, VIRGILIO, ANTONELLA   +8 more
core   +1 more source

Sirtuin functions and modulation: from chemistry to the clinic [PDF]

, 2016
Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia, Carafa, Vincenzo, Cuomo, Francesca, Forgione, Mariantonietta, Hailu, GEBREMEDHIN SOLOMON, Jarho, Elina, Lahtela Kakkonen, Maija, Mai, Antonello, Rotili, Dante, Serretiello, Enrica   +9 more
core   +2 more sources

Arylmethylamino steroids as antiparasitic agents [PDF]

, 2017
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Becker, Katja, Beckmann, Svenja, Blandin, Stéphanie, Brakhage, Axel, Burrows, Jeremy, Dahse, Hans-Martin, Davioud-Charvet, Elisabeth, Elhabiri, Mourad, Goetz, Alice-Anne, Grevelding, Christoph G., Jortzik, Esther, Krieg, Reimar, Nuryyeva, Selbi, Pinkerton, Anthony B., Quack, Thomas, Rahbari, Mahsa, Rahlfs, Stefan, Schönecker, Bruno, Voigt, Kerstin, Wittlin, Sergio   +19 more
core   +3 more sources

Antioxidant and antiproliferative activity of Asparagopsis Taxiformis

Pharmacognosy Research, 2017
Asparagopsis taxiformis (Rhodophyta) is a species of red algae belonging to the family Bonnemaisoniaceae. The objective of the present study was to evaluate antioxidant and antiproliferative activity of four fractions (petroleum ether, chloroform, ethyl acetate, and methanol) of A. taxiformis.The red seaweed, A.
Neethu, P. V., Suthindhiran, K., Jayasri, M. A.   +2 more
openaire   +3 more sources

Antiproliferative Effect of Methanolic Extract of Linum arboreum on A549 Cells

Proceedings, 2017
Many anticancer drugs in clinical use are natural product derived from natural sources. Today, investigations of anti cancer effect of different natural products are increase.
Ozgur Vatan, Ozer Yılmaz, Huzeyfe Huriyet, Tolga Cavas, Nilufer Cinkılıç   +4 more
doaj   +1 more source

Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review [PDF]

, 2015
Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively ...
Battino, Maurizioeditor, Capanoglu, Esra, Grootaert, CharlotteLA23002000065127801001998257F7A30E30-F0ED-11E1-A9DE-61C894A0A6B4, Kamiloglu, SenemUGent0001303221268020017844329746706457840000-0003-3902-4360553D4B12-2C77-11E3-8FFE-9F6610BDE39D, Van Camp, JohnLA238010009006420000-0002-6468-6107F4B233EA-F0ED-11E1-A9DE-61C894A0A6B4   +4 more
core   +3 more sources

Antiproliferative and Antimicrobial Activities of Selected Bryophytes [PDF]

Molecules, 2018
One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5 ...
Martin Vollár, András Gyovai, Péter Szűcs, István Zupkó, Marianna Marschall, Boglárka Csupor-Löffler, Péter Bérdi, Anikó Vecsernyés, Attila Csorba, Erika Liktor-Busa, Edit Urbán, Dezső Csupor   +11 more
openaire   +4 more sources

Targeting EGFR by newer 4,6-Bis((E)-4-hydroxy-3-methoxystyryl)-1-(aryl)pyrimidin-2(1H)-one analogues as antiproliferative agents: eco-friendly chemical modification, in-vitro and in-silico studies

Journal of Taibah University for Science
We reported herein the synthesis, antiproliferative activity and in-silico studies of semi-synthetic curcumin analogues. An equimolar amount of curcumin (A1) and mono aryl urea (B01–B04) were heated in a glycerol-water (1:2, v/v) solvent system at 80°C ...
Md. Faiyaz Ahsan, Mohamed Jawed Ahsan, Mohammad Yusuf, S. Tasqeeruddin, Yahya I. Asiri, Amena Ali, S. Salahuddin   +6 more
doaj   +1 more source

Antiproliferative activity of natural coumarins from Calophyllum incrasaptum M.R Henderson-Wyatt Smith against human breast cancer cells MCF

MATEC Web of Conferences, 2018
Objective: to evaluated the antiproliferative activity of natural coumarin from Calophyllum incrasaptum M.R Henderson-Wytt Smith against human breast cancer cells MCF-7. Methode : Coumarin from ethyl acetate fraction of C. incrasaptum M.R Henderson-Wyatt
Abbas Jamilah, Z Udin Linar, Hanafi Muhammad   +2 more
doaj   +1 more source