Results 21 to 30 of about 155,512 (310)

Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea Derivatives as Antiproliferative Agents

Molecules, 2019
To discover new antiproliferative agents with high efficacy and selectivity, a new series of 1-aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea derivatives (7a–7t) were designed, synthesized and evaluated for their antiproliferative activity against A549,
Chuanming Zhang, Xiaoyu Tan, Jian Feng, Ning Ding, Yongpeng Li, Zhe Jin, Qingguo Meng, Xiaoping Liu, Chun Hu   +8 more
doaj   +1 more source

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Cumhuriyet Science Journal, 2022
In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of ...
Murat Doğan, Mizgin Ermanoğlu, Turan Arabaci, Duygu Taşkın   +3 more
doaj   +1 more source

Chemical investigation of a biologically active schinus molle L. leaf extract [PDF]

, 2019
The pepper tree Schinus molle L. is an evergreen ornamental plant belonging to the Anacardiaceae family, native to South America and widespread throughout the world. It has biological activities and is used in folk medicine. This paper aims to contribute
Garzoli, S., Masci, V. L., Ovidi, E., Tiezzi, A., Turchetti, G., Zago, D.   +5 more
core   +1 more source

Antiproliferative Activity of IL-27 on Melanoma [PDF]

The Journal of Immunology, 2008
Abstract IL-27 is a member of the IL-6/IL-12 family and activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130. We previously demonstrated that IL-27 has potent antitumor activities, which are mediated through CD8+ T cells, NK cells, or its own antiangiogenic activity. In this study, we demonstrate that IL-
Takayuki, Yoshimoto, Noriko, Morishima, Izuru, Mizoguchi, Motomu, Shimizu, Hiroshi, Nagai, Shuntaro, Oniki, Masahiro, Oka, Chikako, Nishigori, Junichiro, Mizuguchi   +8 more
openaire   +2 more sources

Copper Ion Attenuated the Antiproliferative Activity of Di-2-pyridylhydrazone Dithiocarbamate Derivative; However, There Was a Lack of Correlation between ROS Generation and Antiproliferative Activity

Molecules, 2016
The use of chelators for cancer treatment has been an alternative option. Dithiocarbamates have recently attracted considerable attention owning to their diverse biological activities; thus, the preparation of new dithiocarbamate derivatives with ...
Tingting Wang, Yun Fu, Tengfei Huang, Youxun Liu, Meihao Wu, Yanbin Yuan, Shaoshan Li, Changzheng Li   +7 more
doaj   +1 more source

The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

Food Science and Human Wellness, 2023
Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition
Ningxuan Gao, Xu Si, Wenzhong Han, Ersheng Gong, Chi Shu, Jinlong Tian, Yuehua Wang, Jiyue Zhang, Binxu Li, Bin Li   +9 more
doaj   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Antiproliferative activities of alkaloid-like compounds

MedChemComm, 2017
Tricyclic alkaloid-like compounds were synthesised in a few steps, via the bridging Ritter reaction.
XiXi Xu, Tristan Rawling, Ariane Roseblade, Roger Bishop, Alison T. Ung   +4 more
openaire   +3 more sources

Antiproliferative prostaglandins activate heat shock transcription factor. [PDF]

Proceedings of the National Academy of Sciences, 1992
Treatment of human K562 erythroleukemia cells with the antiproliferative prostaglandin A1 results in the elevated transcription of two heat shock genes, HSP70 and HSP90. Parallel with increased heat shock gene transcription is the activation of heat shock transcription factor.
AMICI, CARLA, Sistonen, L, SANTORO, MARIA GABRIELLA, Morimoto, R.   +3 more
openaire   +3 more sources

Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of ‘Ataulfo’ Mango Peel on LS180 Cells

Molecules, 2018
Mango “Ataulfo” peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP’s antioxidant activity.
Gustavo. R. Velderrain-Rodríguez, Heriberto Torres-Moreno, Mónica A. Villegas-Ochoa, J. Fernando Ayala-Zavala, Ramón E. Robles-Zepeda, Abraham Wall-Medrano, Gustavo A. González-Aguilar   +6 more
doaj   +1 more source