Results 61 to 70 of about 98,967 (297)

Synthetic Derivatives of Vinpocetine as Antiproliferative Agents

Drugs and Drug Candidates
Background/Objectives: Vincamine is an indole alkaloid initially isolated from plants of the Vinca genus and has previously been demonstrated to have antioxidant, hypoglycemic, and hypolipidemic activities.
Mihira Gutti, Melanie Tsui, Stella Yang, Selina Xi, Jennifer Luo, Arshia Desarkar, Yining Xie, Mirabelle Feng, Udbhav Avadhani, Shloka Raghavan, Elena Brierley-Green, Erika Yu, Edward Njoo   +12 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Photoswitching off the Antiproliferative Activity of Combretastatin A‑4 Analogues [PDF]

, 2019
The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results ...
Igor V. Zavarzin (1478929), Valerii Z. Shirinian (1478923), Ashot I. Markosyan (3383867), Anton V. Yadykov (7854404), Victoria V. Trofimova (7854407), Alexander M. Scherbakov (6691031), Andrey G. Lvov (3383861)   +6 more
core   +1 more source

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

Antioxidants, 2019
We present the synthesis of a range of benzimidazole/benzothiazole-2-carboxamides with a variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino protonated moieties, which were evaluated for their antiproliferative activity
Maja Cindrić, Irena Sović, Marija Mioč, Lucija Hok, Ida Boček, Petra Roškarić, Kristina Butković, Irena Martin-Kleiner, Kristina Starčević, Robert Vianello, Marijeta Kralj, Marijana Hranjec   +11 more
doaj   +1 more source

Antiproliferative Activity of Amathaspiramide Alkaloids and Analogs

CHEMICAL & PHARMACEUTICAL BULLETIN, 2016
Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results showed amathaspiramides A, C, and E had moderate antiproliferative activity.
Shimokawa, Jun, Chiyoda, Koji, Umihara, Hirotatsu, Fukuyama, Tohru   +3 more
openaire   +3 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Oxadiazoles having antiproliferative activity [PDF]

, 2003
Oxadiazole derivatives of general formula 1 in which X, Y, R and R2 have the meanings defined in the disclosure. The compounds have antiproliferative activity against a number of human tumors cell lines and can therefore be used for the preparation of ...
Cignarella, Giorgio, Murineddu, Gabriele, Pinna, Gérard Aimé   +2 more
core  

Microbial Transformations of Halolactones and Evaluation of Their Antiproliferative Activity [PDF]

, 2023
The microbial transformations of lactones with a halogenoethylocyclohexane moiety were performed in a filamentous fungi culture. The selected, effective biocatalyst for this process was the Absidia glauca AM177 strain.
Bożena Obmińska-Mrukowicz, Karolina Maria Zych, Aleksandra Pawlak, Marcelina Mazur   +3 more
core   +1 more source