Results 61 to 70 of about 6,141,319 (295)

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

Advanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo, So Yun Lim, Dong‐Sung Won, Ji Won Kim, Yubeen Park, Song Hee Kim, Hyemin Lee, Jung‐Min Ahn, Jun‐Kyu Park, Do‐Yoon Kang, Jung‐Hoon Park   +10 more
wiley   +1 more source

Effect of the A. phalerata oil in antiproliferative activity.

, 2018
Effect of the A. phalerata oil in antiproliferative activity.
Fernando Freitas de Lima (3232629), Iluska Senna Bonfá Moslaves (5082011), Renata Trentin Perdomo (5082008), Cláudia Andrea Lima Cardoso (5082023), Simone Schneider Weber (111526), Cândida Aparecida Leite Kassuya (3769498), Maria do Carmo Vieira (662428), Thalita Vieira do Nascimento Ximenes (5082014), Caroline Honaiser Lescano (3232635), Monica Cristina Toffoli Kadri (5082020), Jucicléia da Silva Arrigo (3769546), Eliana Janet Sanjinez-Argandoña (3179856), Janclei Pereira Coutinho (5082017)   +12 more
core   +1 more source

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

Molecules, 2014
A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones 2a–n.
Abdulrahman I. Almansour, Raju Suresh Kumar, Farzana Beevi, Amir Nasrolahi Shirazi, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Brian Sullivan, Kellen McCaffrey, Alaa Nahhas, Keykavous Parang, Mohamed Ashraf Ali   +11 more
doaj   +1 more source

The antiproliferative potential and mechanism of action of metformin in MCF-7 cells

Future Science OA, 2023
Aim: The current study aimed to investigate the potential antiproliferative activity of metformin, the effective concentration range, and the mechanism of action.
Zhibek Bekezhankyzy, Sholpan Nurzhan, Nurken Berdigaliyev, Shynggys Sergazy, Tilektes Maulenkul, Mohamad Aljofan   +5 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

Antioxidants, 2019
We present the synthesis of a range of benzimidazole/benzothiazole-2-carboxamides with a variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino protonated moieties, which were evaluated for their antiproliferative activity
Maja Cindrić, Irena Sović, Marija Mioč, Lucija Hok, Ida Boček, Petra Roškarić, Kristina Butković, Irena Martin-Kleiner, Kristina Starčević, Robert Vianello, Marijeta Kralj, Marijana Hranjec   +11 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Correction to Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells

, 2020
Correction to Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer ...
Anna Herman-Antosiewicz, Beata Guzow-Krzemińska, Rajeshwar Narlawar (536844), Rajeshwar Narlawar, Beata Guzow-Krzemińska (6920477), Anna Herman-Antosiewicz (29980), Agnieszka Pyrczak-Felczykowska (6920474), Aleksandra Hać (6920483), Louis M. Rendina (1484386), Michael Kassiou (281876), Tristan A. Reekie (2022892), Louis M. Rendina, Anna Pawlik (6298439), Kamil Ryś (6920486), Michael Kassiou, Damian Artymiuk (6920480), Kamil Ryś, Anna Pawlik, Tristan A. Reekie, Aleksandra Hać, Agnieszka Pyrczak-Felczykowska, Damian Artymiuk   +21 more
core   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source