Results 141 to 150 of about 98,614 (298)

Antiproliferative effect of benzophenones and their influence on cathepsin activity

, 2015
CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFINEP – FINANCIADORA DE ESTUDOS E PROJETOSThe antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated garciniaphenone and the ...
Kohn, Luciana K., Nagem, Tanus Jorge, dos Santos, Marcelo Henrique, Murata, Ramiro Mendonça, Yatsuda, Regiane, de Carvalho, João Ernesto, Rosalen, Pedro Luiz, Martins, Felipe Terra, Alencar, Severino Matias   +8 more
core   +1 more source

Synthesis and Characterization of Juglone‐Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico

Journal of Applied Toxicology, EarlyView.
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Mustafa Öztatlıcı, Turan Birimoğlu, Semih Güler, Rukiye Betül Çolaksel, Mehmet Tahir Husunet, Mehmet Sönmez   +5 more
wiley   +1 more source

Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity

, 2013
Chromenopyrazolediones have been designed and synthesized as anticancer agents using the multi-biological target concept that involves quinone cytotoxicity and cannabinoid antitumor properties.
Gómez-Cañas, María, Díaz-Laviada, Inés, Díaz-Laviada Marturet, Inés, Zúñiga, María C., Jagerovic, Nadine, Zúñiga, María, Gómez Cañas, María, Fernández Ruiz, José Javier, Morales, Paula, Vara, Diana, Goya, Pilar, Olea-Azar, Claudio, Fernández-Ruiz, Javier   +12 more
core   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

Spelt Grass Juice: Phytochemicals and Antiproliferative Activity

Applied Sciences
Spelt is gaining popularity due to its nutritional and ecological benefits, particularly in organic farming. Juice from young spelt grass is rich in potassium, phosphorus, manganese, and chromium, along with beneficial pigments and phenolic compounds, all of which support human health.
Ana Topalović, Mirko Knežević, Maja Mikulic-Petkovsek, Jasminka Mrđanović   +3 more
openaire   +3 more sources

Effect of thermosonication on the UHPLC‐QTOF‐IMS‐based metabolomic profile of orange juice

JSFA reports, EarlyView.
Abstract Background This study investigated the impact of thermosonication on the metabolomic profile of orange juice to understand processing‐induced alterations in bioactive compounds and quality attributes. Results Moderate thermosonication at 45°C preserved structural siloxanes and certain amino acids, whereas higher temperatures between 60 and 75 ...
Deepti Kothari, Arun Kumar, Saloni Joshi, Desta Dugassa Fufa, Sajad Ali   +4 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line

, 2011
The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described.
���������
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source