Results 161 to 170 of about 5,874,294 (289)

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Endophytic Aspergillus glaucus as a novel epothilone B producer: Antiproliferative activity and in silico analysis. [PDF]

Appl Microbiol Biotechnol
El-Sayed ASA, Refaat S, El-Sayed MA, Fikry E, Tawfeek N, El-Domiaty MM, El-Shafae AM.   +6 more
europepmc   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of Fluorinated <i>N</i>-Acetylmannosamine Analogs. [PDF]

J Org Chem
Krčil A, Šutvajová L, Hamala V, Císařová I, Kurfiřt M, Červenková Št'astná L, Bernášková J, Hrstka R, Karban J.   +8 more
europepmc   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Development of Glycoconjugated MAGL Inhibitors with Glucose-Dependent Antiproliferative Activity. [PDF]

Int J Mol Sci
Bononi G, Bertini F, Masoni S, Stefano MD, Mosca R, Felice F, Signore G, Minutolo F, Granchi C, Tuccinardi T, Di Bussolo V.   +10 more
europepmc   +1 more source

Snake Gut Microbiota as a Source of Anti‐Inflammatory Probiotics: Isolation and Functional Characterization of Two Novel Strains

Integrative Zoology, EarlyView.
This study assessed the probiotic potential of intestinal microbiomes from five snake species using metagenomics and in vitro isolation, identifying two promising strains (Lactobacillus johnsonii DA0116 and Limosilactobacillus reuteri DA0218) through comprehensive screening.
Xuena Kang, Lan Hu, Jiarong Song, Zhenjie Zhang, Yi Li, Qingqing Zhang, Cuiling Luo, Yu Pang, Peng Guo, Bisong Yue, Ping Li, Zhenxin Fan   +11 more
wiley   +1 more source

New aminoadamantane derivatives with antiproliferative activity

, 2014
1-Benzyl-2-aminoadamantanes 2a-c, conformationally constrained aminoadamantanes 3a, b and 4 and diaminoadamantanes derivatives 5a-c, 6a-c were synthesized and tested as antiproliferative agents.
Kolocouris, N., Papanastasiou, I., Vamvakides, A., Nikas, S.P., Tsotinis, A.   +4 more
core  

Proliferative vitreoretinopathy: An integrative, multi‐pathway perspective on pathogenesis and therapy

Acta Ophthalmologica, EarlyView.
Abstract Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment‐restricted mechanisms do not fully explain the heterogeneity, biomechanical behaviour and clinical ...
Koen A. van Overdam, J. Sebag
wiley   +1 more source

Development of Amorphous Solid Dispersion to Improve the Dissolution and Antiproliferative Activity of Brazilin. [PDF]

Drug Des Devel Ther
Tristiyanti D, Sriwidodo S, Hamdani S, Daruwati I, Budiman A.   +4 more
europepmc   +1 more source