Results 181 to 190 of about 5,874,294 (289)

Pyrimidine- and furo[2,3-<i>d</i>]pyrimidine-isoxazole hybrids and their Re(i) tricarbonyl complexes with antiproliferative activity against hematological malignancies. [PDF]

RSC Med Chem
Piškor Benković M, Ćorić I, Sačer L, Damjanović L, Mišković Špoljarić K, Perić B, Kirin SI, Glavaš-Obrovac L, Raić-Malić S.   +8 more
europepmc   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Structure-guided discovery and evaluation of an EGFR L858R-targeting peptide with antiproliferative activity against ovarian cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhu Y, Wu H, Liu X, Li R, Jiang M.
europepmc   +1 more source

Clinical outcomes of intratumoural para‐toluenesulfonamide treatment in equine melanoma

Equine Veterinary Education, EarlyView.
Summary Equine melanoma is one of the most common cutaneous neoplasms in horses and is particularly prevalent in grey horses. Although these tumours often demonstrate indolent biological behaviour, some progressively develop locally invasive or malignant characteristics over time, making treatment decisions challenging in clinical practice.
H.‐C. Lo, H. Yan‐Der, P.‐L. Chang, M.‐Y. Lin, S. Kee   +4 more
wiley   +1 more source

Discovery of a novel and potent KRAS^G12V-targeting peptide with antiproliferative activity against colorectal cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhang H, Yang S, Wang Y, Niu MM, She J.
europepmc   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Stereoselective Synthesis and Antiproliferative Activity of Nemamide Analogs. [PDF]

J Nat Prod
Yu R, Gonzalez MS, Rakshit S, Li Y, Dar AR, Li X, Butcher RA.   +6 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Chemical Profiling and ROS-Dependent Antiproliferative Activity of Artemisia nilagirica (C.B.Clarke) Pamp. (Asteraceae) Essential Oil in Human Gastric Adenocarcinoma Cells. [PDF]

Chem Biodivers
Kunnathattil M, Narayanankutty A, Menon S, Kaimal SG.   +3 more
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source