Results 191 to 200 of about 6,141,319 (295)

Structure-based screening and identification of a novel Aurora-A-targeting peptide with antiproliferative activity against prostate cancer cells. [PDF]

J Enzyme Inhib Med Chem
Huang BB, Jiang H, Hu Y, Ge JJ, Liu X.
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Isolation and Characterisation of Alkaloids from Marine-Derived <i>Aspergillus fumigatus</i> SYPHU504 with Antiproliferative Activity. [PDF]

Mar Drugs
Zhang X, Yu Y, Liu K, Liu Y, Zhang H, Xiao J.   +5 more
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Evidence of Antiproliferative Activity in the Liverwort <i>Isotachis serrulata</i> from Southern Ecuador. [PDF]

Molecules
Andrade JM, Benítez Á, González-Bakker A, Cartuche L, Padrón JM, Díaz-Marrero AR, Fernandez JJ.   +6 more
europepmc   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Design, synthesis and antiproliferative activity of pyridone derivatives as potent enhancer of zeste homologue 2/histone deacetylase dual inhibitors. [PDF]

RSC Adv
Tan Z, Ding J, Chen X, Qian L, Yu Q.
europepmc   +1 more source

Stress‐specific metabolic and physiological responses to drought and waterlogging in Allium cepa L. and Allium × cornutum Clementi ex Vis.

Plant Biology, EarlyView.
Drought and waterlogging induce distinct species‐specific metabolic, physiological and transcriptional responses in Allium cepa and Allium × cornutum. Abstract Increasing variability in water availability, caused by changing climatic conditions, is a major constraint for onion production.
Ž. Fredotović, B. Soldo, B. Urlić, K. Radovani, E. Vuko, J. Puizina   +5 more
wiley   +1 more source

Pyrimidine- and furo[2,3-<i>d</i>]pyrimidine-isoxazole hybrids and their Re(i) tricarbonyl complexes with antiproliferative activity against hematological malignancies. [PDF]

RSC Med Chem
Piškor Benković M, Ćorić I, Sačer L, Damjanović L, Mišković Špoljarić K, Perić B, Kirin SI, Glavaš-Obrovac L, Raić-Malić S.   +8 more
europepmc   +1 more source