Results 191 to 200 of about 5,874,294 (289)

Phenotype-Oriented Characterization of NSC828786 Identifies Convergent HPN-AMACR-Associated Transcriptomic Signatures in Prostate Adenocarcinoma and Broad-Spectrum Antiproliferative Activity. [PDF]

Cells
Wen YT, Manalu RT, Hsu HL, Kuo YC, Soong RS, Liu FC, Sumitra MR, Huang SL, Lee SY, Tang SL, Yen IC, Wang HJ, Lawal B, Wu ATH, Huang HS.   +14 more
europepmc   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Synthesis and <i>in vitro</i> antiproliferative activity of dolutegravir derivatives against hepatocellular carcinoma <i>via</i> apoptosis-related mechanisms. [PDF]

RSC Adv
Hou X, Huang M, Zhang Q, Yao Q, Yang J.
europepmc   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Strong Antiproliferative Activity Observed in Hammett-Guided Electronic Modulation of GPx-Mimetic Pathways in Aryl Selenoureas. [PDF]

Int J Mol Sci
Begines P, Pérez-Lage CI, Puerta A, Padrón JM, López Ó, Fernández-Bolaños JG.   +5 more
europepmc   +1 more source

Stress‐specific metabolic and physiological responses to drought and waterlogging in Allium cepa L. and Allium × cornutum Clementi ex Vis.

Plant Biology, EarlyView.
Drought and waterlogging induce distinct species‐specific metabolic, physiological and transcriptional responses in Allium cepa and Allium × cornutum. Abstract Increasing variability in water availability, caused by changing climatic conditions, is a major constraint for onion production.
Ž. Fredotović, B. Soldo, B. Urlić, K. Radovani, E. Vuko, J. Puizina   +5 more
wiley   +1 more source

Discovery of Primaquine-Indole Carboxamides with Cancer-Cell-Selective Antiproliferative Activity. [PDF]

Molecules
Peer BH, Olugbami JO, Walunj DT, Oyelere AK.   +3 more
europepmc   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Extraction Strategy and C18 Solid-Phase Fractionation Shape Phenolic Profiles, Antioxidant Capacity, and Cancer Cell Antiproliferative Activity of Selected Medicinal Plants. [PDF]

Antioxidants (Basel)
Armonavičius D, Maruška A, Bimbiraitė-Survilienė K, Stankevičius M, Jakštys B, Drevinskas T, Gabrytė U, Skrzydlewska E, Ragažinskienė O, Kaškonienė V, Šatkauskas S, Pečiulienė I, Kanopka A.   +12 more
europepmc   +1 more source

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast (Malassezia pachydermatis) Otitis Externa in Dogs

Veterinary Dermatology, EarlyView.
Background: Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials.
Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia   +4 more
wiley   +1 more source