Results 211 to 220 of about 5,874,294 (289)

Sulfonylated Goniothalamin and Piplartine Derivatives Exhibit Selective Antiproliferative Activity on Breast Cancer Cells via Oxidative Stress-Mediated Mechanisms. [PDF]

ACS Omega
Nacif JLM, Bartolomeu AA, Lamartine-Hanemann SDS, Zavan B, Nascimento LM, Caixeta ES, Aissa AF, Pilli RA, Ionta M.   +8 more
europepmc   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 10, Page 2072-2084, October 2026.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

Virtual screening and experimental validation of a METTL3-targeting peptide with <i>in vitro</i> antiproliferative activity against non-small cell lung cancer cells. [PDF]

J Enzyme Inhib Med Chem
Dai Y, Wu H, Shen Y, Yang F, Liu X, Zhuang T.   +5 more
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Design, Synthesis, and Selective Antiproliferative Activity of Indolizine Derivatives as Microtubule Destabilizers. [PDF]

Arch Pharm (Weinheim)
Fernandes VHC, Giometti MB, Caires FJ, Bueno GP, da Silva G, Leopoldino AM, Junker A, Clososki GC.   +7 more
europepmc   +1 more source

Cross‐Talk Between Histamine H2 Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)‐mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific agonist, amthamine, enhances GR transcriptional ...
Valeria Torralba‐Agu, Natalia Fernández, Carina Shayo, Carlos Davio, C. Daniel Zappia, Federico Monczor   +5 more
wiley   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Roburic Acid as a Therapeutic Candidate: Antiproliferative Activity and Secondary Cell Death Response in Colorectal Cancer Cells. [PDF]

Int J Mol Sci
Gielecińska A, Kciuk M, Gruszka R, Wawrocki S, Kontek R.   +4 more
europepmc   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Proposed Allosteric Inhibition of Cyclin-Dependent Kinase 4 by a Proline-Derived Acylsemicarbazide Compound with Antiproliferative Activity in Breast Cancer Cells. [PDF]

Pharmaceuticals (Basel)
Huang X, Nian Q, Sun X, Zhou Y, Wang Y, Yue J, Meng F, Liang J.   +7 more
europepmc   +1 more source