Results 211 to 220 of about 155,512 (310)

Antiproliferative activity, phytochemistry, network pharmacology, molecular docking and gene expression analysis of Maerua edulis extracts against human cervical cancer cell line. [PDF]

BMC Complement Med Ther
Lagu IJL, Letoluo R, Kamau SW, Kuria JM, Musila FM, Kungurtsev V, Nyamai DW, Njeru SN.   +7 more
europepmc   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Exploring the Antiproliferative Activity of Flavolignans From the Leaves of Casearia arborea (Salicaceae). [PDF]

Chem Biodivers
Santos AL, Rodrigues MT, Michelli AP, Tamura RE, de Rubió IGS, Soares MG, Ferreira MJP, Sartorelli P.   +7 more
europepmc   +1 more source

Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. [PDF]

, 1993
Duquesnoy, RJ, Fung, JJ, Starzl, TE, Todo, S, Venkataramanan, R, Yao, GZ, Zeevi, A   +6 more
core  

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Evaluation of Antiproliferative Activity and Molecular Modeling Studies of Some Novel Benzimidazolone-Bridged Hybrid Compounds. [PDF]

Pharmaceuticals (Basel)
Güven O, Menteşe E, Yılmaz F, Güner A, Emirik M, Çalışkan N.   +5 more
europepmc   +1 more source

Artesunate Induces G0/G1 Phase Arrest in Tumor Cells and Associates With Cyclin‐Dependent Kinase 4 (CDK4)

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death worldwide. Cyclin‐dependent kinase 4 (CDK4) is a well‐validated oncogenic driver in NSCLC, yet current CDK4 inhibitors—predominantly based on the aminopyrimidine scaffold—are limited by structural homogeneity and the rapid emergence of acquired ...
Xinyu Chi, Qicong Chen, Gang Wang, Honglin Luo, Shenhong Qu, Xiaosu Zou   +5 more
wiley   +1 more source

Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Introduction Cervical cancer remains a leading cause of cancer‐related mortality among women globally, particularly in low‐ and middle‐income countries. Cisplatin, a standard chemotherapeutic agent, is limited by severe toxicities and chemoresistance. This study aimed to assess the effects of cisplatin in combination with phytocannabinoids, Δ9‐
S. P. Mathibela, M. T. Lebelo, V. Steenkamp   +2 more
wiley   +1 more source

Polyamine catabolism activating agents show antiproliferative activity

, 2020
Neborak E., Syatkin S., Sungrapova K., Korshunova A., Hilal A., Muhana L., Kutyakov S., Sokuev R., Eremina I., Smirnova I., Gushchina Y., Shcherbakov A.   +11 more
openaire   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source