Results 221 to 230 of about 6,141,319 (295)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Phytochemical compounds, antioxidant activity, and antiproliferative activity of sesame seeds as affected by simulated digestion. [PDF]

Food Chem X
Zhou L, Lin X, Guo R, Li T, Brennan C, Fu X, Liu RH.   +6 more
europepmc   +1 more source

γ‐T3 Increases the Sensitization of Gastric Cancer Cells to OXA by a Regulation of ARHGAP29

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
γ‐T3 combined with oxaliplatin (OXA) inhibited the proliferation of gastric cancer cells by induction autophagy via ARHGAP29/GSK‐3β/β‐Catenin pathways. γ‐T3 combined with low‐dose of OXA could exert synergistic effects on induction autophagy‐related gastric cancer cell death, which is partially mediated by down‐regulation of the ARHGAP29/GSK‐3β/β ...
Hao Zhu, Fa‐Lin Wang, Shuang Zhang, Ting‐Ting Yang, Guang‐Qiang Gao, Hong Tian, Li Xue, Hong‐Wei Dong, Qi Wang, Shu‐Jun Zhang, Ming Liu, Jia‐Ren Liu   +11 more
wiley   +1 more source

Sinensetin Induces Oxidative Stress‐Mediated Apoptosis in Non‐Small Cell Lung Cancer Cells by Suppressing Nrf2/ARE‐Dependent Antioxidant Defense

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Sinensetin suppresses Nrf2/ARE signaling, increases intracellular ROS, and promotes mitochondrial apoptosis in A549 NSCLC cells. Partial rescue by NAC and Nrf2 overexpression supports a functional role for oxidative stress and Nrf2 suppression in the observed anticancer response.
Junyan Li, Ruoyun He, Jiake He, Jian Ye, Yu Xie, Binfan Yuan   +5 more
wiley   +1 more source

Design, synthesis, and antiproliferative activity of novel thiazole-based derivatives as tubulin polymerization inhibitors targeting the colchicine binding site. [PDF]

RSC Adv
Al-Wahaibi LH, Elshamsy AM, Ali TFS, Youssif BGM, Bräse S, Abdel-Aziz M, El-Koussi NA.   +6 more
europepmc   +1 more source

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base–Thiosemicarbazone Hybrids

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber M Anber, Mehmet Özbay, İlhan Özer İlhan, Hüseyin Kekeçmuhammed, Rıfat Emin Bora, Emin Saripinar, Yalçın Erzurumlu, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Lamya Ahmed Alkeridis, Senem Akkoc   +10 more
wiley   +1 more source

Design, synthesis, and <i>in vitro</i> antiproliferative activity of novel 4-amino-6-phenoxyquinoline and 4,6-diphenoxyquinoline. [PDF]

RSC Adv
Al-Sheikh A, Abuoun M, Khalaf H, Albaz N, Zaytoun A, Abuarqoub D.   +5 more
europepmc   +1 more source

Ameliorative Effect of Lycopene and Capsaicinoid Glucoside in Acute Myeloid Leukemia

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Lycopene and capsaicinoid glucoside synergistically reduce leukemia cell proliferation, restore oxidative balance, and normalize hematological parameters in benzene‐induced rat models, demonstrating potent anti‐apoptotic and cytotoxic effects in vitro and in vivo.
Somia Shehzadi, Muhammad Abbas Shahid, Shaista Nazir, Murtaza Mansoor, Asmat Ullah, Fatima Iftikhar Shah, Zaid Talal Abdulqader Ali   +6 more
wiley   +1 more source

Design, Synthesis, and Selective Antiproliferative Activity of Indolizine Derivatives as Microtubule Destabilizers. [PDF]

Arch Pharm (Weinheim)
Fernandes VHC, Giometti MB, Caires FJ, Bueno GP, da Silva G, Leopoldino AM, Junker A, Clososki GC.   +7 more
europepmc   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, Volume 106, Issue 14, Page 8298-8314, November 2026.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source