Results 201 to 210 of about 155,512 (310)

Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives. [PDF]

ChemMedChem
Houngbedji PA, Nawrot DE, Janďourek O, Konečná K, Novák M, Paterová P, Bárta P, Rambaher MH, Novotná E, Castellano C, Mori M, Meneghetti F, Záhorszká M, Korduláková J, Zitko J.   +14 more
europepmc   +1 more source

Edulitin 2, a Ribotoxin‐Like Protein From Boletus edulis That Triggers Apoptosis in Colon Cancer Cells While Preserving the Integrity of the Intestinal Microbiota

eFood, Volume 7, Issue 3, June 2026.
Edulitin 2 is a ribotoxin‐like protein exhibiting a potent antiproliferative activity towards Caco‐2 and HT29 cells by programmed cell death. However, edulitin 2 does not affect gut microbiota growth, despite damaging fungal ribosomes. ABSTRACT Porcini (Boletus edulis Bull.) are a reservoir of pharmacological biomolecules with health‐promoting ...
Massimo Bortolotti, Sara Ragucci, Federica Falà, Anella Saggese, Francesco Biscotti, Ylenia De Luca, Nicola Landi, Paolo V. Pedone, Andrea Bolognesi, Ezio Ricca, Letizia Polito, Antimo Di Maro   +11 more
wiley   +1 more source

In Vitro Antiproliferative Activity in Plants of the Genus Tabebuia: A Systematic Review. [PDF]

Molecules
Mosquera-Morales L, Orozco LM, Veloza LA, Sepúlveda-Arias JC.   +3 more
europepmc   +1 more source

Induction of Apoptosis in MCF‐7 Breast Cancer Cells by Selenium Nanoparticles Synthesized With Laccase Enzyme Isolated From Pleurotus Floridanus

eFood, Volume 7, Issue 3, June 2026.
This study showed the first successful synthesis of selenium nanoparticles (SeNPs) using laccase purified from Pleurotus floridanus, offering an eco‐friendly and biocompatible replacement to conventional chemical methods. The biosynthesized SeNPs exhibited significant antiproliferative effects on MCF‐7 breast cancer cells, with cell cycle analysis ...
Shenbhagaraman Ramalingam, Arthi Karunanithi, Ammar B. Altemimi, Jenefar Sudarson, Sakthivel Muthu, Kodiganti Naresh Kumar, Rawaa H. Tlay, Tarek Gamal Abedelmaksoud   +7 more
wiley   +1 more source

Design, Synthesis and Antiproliferative Activity Studies of Novel 1,2,3-Triazole-Urea Hybrids. [PDF]

Drug Des Devel Ther
Gao E, Zhang H, Guo Y, Wang X, Mao L, Peng L, Xu G, Yao X, Li S, Long H, Wang T, Wu H.   +11 more
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Chemical Constituents and Antiproliferative Activity Against RAFLs and HepG2 Cells of <i>Clematis henryi</i>. [PDF]

Int J Mol Sci
Wang B, Wang MY, Yang YP, Su W, Jiang X, Liu SQ, Luo QJ, Zhou WC, Liang L, Zheng H, Xie QL, Yu HH, Jian YQ, Zhou XD, Li B, Peng CY, Wang W.   +16 more
europepmc   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

Targeting colorectal cancer with hesperidin and hesperetin: a comprehensive review of antiproliferative activity, chemopreventive, anti-inflammatory, and antioxidant effects. [PDF]

Front Nutr
Qi M, Su Y.
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source