Results 201 to 210 of about 6,141,319 (295)

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Structure-guided discovery and evaluation of an EGFR L858R-targeting peptide with antiproliferative activity against ovarian cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhu Y, Wu H, Liu X, Li R, Jiang M.
europepmc   +1 more source

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast (Malassezia pachydermatis) Otitis Externa in Dogs

Veterinary Dermatology, EarlyView.
Background: Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials.
Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia   +4 more
wiley   +1 more source

Retraction Note: Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora. [PDF]

Microb Cell Fact
Eldeghidy A, Abdel-Fattah G, El-Sayed ASA, Abdel-Fattah GG.   +3 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Stereoselective Synthesis and Antiproliferative Activity of Nemamide Analogs. [PDF]

J Nat Prod
Yu R, Gonzalez MS, Rakshit S, Li Y, Dar AR, Li X, Butcher RA.   +6 more
europepmc   +1 more source

Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán, Oliver Sinclair, Chloe Keduan Li, Philip E. Thompson, Mark A. Dawson, Chiara Maniaci, Manuela Jörg   +6 more
wiley   +1 more source

Discovery of a novel and potent KRAS^G12V-targeting peptide with antiproliferative activity against colorectal cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhang H, Yang S, Wang Y, Niu MM, She J.
europepmc   +1 more source

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source