Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang +7 more
wiley +1 more source
Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang +4 more
wiley +1 more source
Self-Assembled Cannabigerol-Based Nanoparticles: Design, Synthesis, and Antiproliferative Activity. [PDF]
Amenta A +13 more
europepmc +1 more source
African walnut oil and docosahexaenoic acid administration to female Wistar rats with DMBA‐induced breast cancer may delay tumor growth, increase white blood cells, platelets and mean corpuscular hemoglobin counts in the blood. DMBA significantly lowers red blood cells, hemoglobin levels, and protein concentration.
Fabrice Tonfack Djikeng +3 more
wiley +1 more source
In vitro and in vivo approaches demonstrating the antiproliferative activity of pomegranate seed proteins and peptides on breast cancer. [PDF]
Guzmán-Lorite M +4 more
europepmc +1 more source
Synthesis, Characterization, and Cytotoxic Activity Properties of Some Novel Purine Derivatives
Nine novel purine derivatives were successfully synthesized and its cytotoxic activities were evaluated against HepG2 and MDA‐MB‐231 cancer cell lines. ABSTRACT This study reports the synthesis of nine new compounds with purine scaffolds. It thoroughly analyzes them using a variety of spectroscopic methods, including high‐resolution mass spectrometry ...
Nurdan Akdoğan +6 more
wiley +1 more source
Antiproliferative activity of Moringa oleifera (L.) Lam. and Moringa stenopetala (Bak.) Cufod. leaves extract against selected cancer cells in primary cell culture. [PDF]
Assaye MA +7 more
europepmc +1 more source
Potential of solid‐state microwaves in lab‐scale chemical‐process development
Abstract BACKGROUND The integration of a solid‐state microwave (MW) generator into a newly designed, versatile MW reactor ensures improved energy efficiency, precise process control and broader application potential. In its most particular feature, the device supports the modification of dielectric‐radiation orientation and can be operated under ...
Christian Cravotto +4 more
wiley +1 more source
Discovery of First-in-Class Carbonic Anhydrase/Histone Deacetylase Dual Inhibitors with Antiproliferative Activity in Cancer Cells. [PDF]
Bozdag M +16 more
europepmc +1 more source
The barley–malt–beer chain: A process and food safety approach
Abstract This review addresses the current state of knowledge on the barley–malt–beer chain and its main physical, chemical, and microbiological contaminants, with particular emphasis on spoilage microorganisms and their toxic metabolites. The barley–malt–beer production chain represents a mature and globally relevant agro‐industrial sector that ...
José Gómez‐Espinoza +5 more
wiley +1 more source

