DIMP53-1:A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties [PDF]
, 2017 The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53-targeted therapies are among the most encouraging anticancer strategies.
Baeriswyl +23 more
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Antiproliferative activity of Haematoxylum brasiletto H. Karst
Pharmacognosy Magazine, 2017 Haematoxylum brasiletto is a tree that grows in Central America, commonly known as "Palo de Brasil," which is used in the traditional medicine for the treatment of cancer and gastric ulcers.The aim of this study was to isolate the compounds responsible for antiproliferative activity of H. brasiletto.A bioassay-guided fractionation of ethanol extract of
Bello-Martínez, J +7 more
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α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]
, 2016 α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia +4 more
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Enzyme prodrug therapy achieves site-specific, personalized physiological responses to the locally produced nitric oxide [PDF]
, 2018 Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings ...
Alexander N. Zelikin +12 more
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Norhierridin B, a new hierridin B-based hydroquinone with improved antiproliferative activity [PDF]
, 2020 Joana Moreira +10 more
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Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity
Journal of Ginseng Research, 2014 Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng.
Thi Hong Van Le +7 more
doaj +1 more source
Synthesis and antiproliferative activity of 6-phenylaminopurines
European Journal of Medicinal Chemistry, 2014 A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative ...
María-Dolores Canela +4 more
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Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis [PDF]
, 2004 A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in ...
Baianu, Professor I.C. +1 more
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The Synthesis and Antiproliferative Activities of New Arylidene-Hydrazinyl-Thiazole Derivatives [PDF]
, 2014 Adriana Grozav +7 more
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Synthesis and antiproliferative activity of 1-methoxy-, 1-(α-D-ribofuranosyl)- and 1-(β-D-ribofuranosyl)brassenin B [PDF]
, 2008 Zuzana Čurillová +5 more
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