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Antiproliferative and Cytotoxic Activities
2018Cancer is a genetic disease, affecting many people worldwide. Chemotherapy is routinely used for cancer treatment. However, this therapeutic approach is not always effective due to the development of cell resistance and toxic effects. Plants are a reservoir of natural chemicals with chemoprotective potential against cancer and with low adverse effects.
Anesini, Claudia Alejandra +2 more
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Antioxidant and Antiproliferative Activities of Common Fruits
Journal of Agricultural and Food Chemistry, 2002Consumption of fruits and vegetables has been associated with reduced risk of chronic diseases such as cardiovascular disease and cancer. Phytochemicals, especially phenolics, in fruits and vegetables are suggested to be the major bioactive compounds for the health benefits.
Jie, Sun +3 more
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Synthesis and antiproliferative activity of novel methylselenocarbamates
European Journal of Medicinal Chemistry, 2014A series of new aliphatic, aromatic and heteroaromatic carbamate derivatives containing a methylseleno moiety were synthesized and evaluated in vitro for their cytotoxic activity against a panel of human cell lines including CCRF-CEM (lymphoblastic leukaemia), K-562 (lymphocytic leukaemia), HT-29 (colon carcinoma), HTB-54 (lung carcinoma), PC-3 ...
Beatriz Romano +4 more
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Antiangiogenic and antiproliferative activity of suramin analogues
Cancer Chemotherapy and Pharmacology, 1997The purpose of this study was to test the ability of 70 polyanionic analogues of suramin to inhibit angiogenesis. The ID50, the dose that produced 50% inhibition of angiogenesis, was determined for suramin and each of the analogues by measuring the ability of various amounts to inhibit angiogenesis in vivo in the chick egg chorioallantoic membrane (CAM)
A R, Gagliardi +5 more
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Anticancer and antiproliferative activity of natural brassinosteroids
Phytochemistry, 2008Brassinosteroids (BRs) are steroid plant hormones that are essential for many plant growth and developmental processes, including cell expansion, vascular differentiation and stress responses. Up to now the inhibitory effects of BRs on cell division of mammalian cells are unknown.
Jana, Malíková +3 more
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Antiproliferative activity of novel harmirins
2021β-Carbolines and coumarins are two classes of phytochemicals possessing a wide variety of biological activities, including anticancer properties.[1, 2] As a continuation of our work on hybrid compounds, we have prepared a series of harmirins – novel hybrid molecules comprising harmine, a representative of β-carbolines, and coumarin moieties linked by a
Pavić, Kristina +3 more
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Antiproliferative activity of chalcones with basic functionalities
Bioorganic & Medicinal Chemistry, 2007A library of chalcones with different basic groups were synthesized and evaluated for antiproliferative activities against the human breast cancer (MCF 7) and colon cancer (HCT 116) cell lines. Structure-activity relationships were analyzed by projection methods (PCA/PLS) and multiple linear regression.
Liu, X., Go, M.-L.
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Synthesis and antiproliferative activity of 6-naphthylpterocarpans
Organic & Biomolecular Chemistry, 2020The Heck-oxyarylation of 2H-chromenes afforded (6S*,6aR*,11aR*)-6-naphthylpterocarpans with potent antiproliferative activity. Absolute configurations and conformations of the separated enantiomers were determined by TDDFT-ECD calculations.
Ádám Szappanos +7 more
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Antioxidant and antiproliferative activity of curcumin semicarbazone
Bioorganic & Medicinal Chemistry Letters, 2005A new semicarbazone derivative of curcumin (CRSC) was synthesized and examined for its antioxidant, antiproliferative, and antiradical activity and compared with those of curcumin (CR). The antioxidant activity was tested by their ability to inhibit radiation induced lipid peroxidation in rat liver microsomes.
Sabari, Dutta +3 more
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Antiproliferative activity of salinomycin and its derivatives
Bioorganic & Medicinal Chemistry Letters, 2012Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines.
Adam, Huczyński +5 more
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