Results 51 to 60 of about 162,577 (262)

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]

, 2017
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da, Bernardi, A, Colombo, G. 1., D'Annessa, I, Moroni, E, Pennati, M, Rasola, Andrea, SANCHEZ MARTIN, Carlos, Sattin, S, Tao, J, Zaffaroni, N   +10 more
core   +1 more source

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

BMC Complementary and Alternative Medicine, 2013
Background The aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri ...
Jiménez-Estrada Manuel, Velázquez-Contreras Carlos, Garibay-Escobar Adriana, Sierras-Canchola Davisela, Lapizco-Vázquez Ricardo, Ortiz-Sandoval Carolina, Burgos-Hernández Armando, Robles-Zepeda Ramón Enrique   +7 more
doaj   +1 more source

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando, Cardama, Georgina Alexandra, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gandolfi Donadío, Lucía, Gomez, Daniel Eduardo, González, Nazareno, Lorenzano Menna, Pablo   +7 more
core   +2 more sources

The Tumor Cell Proliferation Inhibitory Activity of the Human Herpes Virus Type 6 U94 Protein Relies on a Stable Tridimensional Conformation

Microorganisms
The U94 protein of Human Herpesvirus 6 exerts antiproliferative effects through downregulation of the Src proto-oncogene. We aimed to define the shortest U94 fragment that preserves antiproliferative activity and to explore its structural properties. U94
Anna Bertelli, Matteo Uggeri, Federica Filippini, Melissa Duheric, Francesca Caccuri, Arnaldo Caruso   +5 more
doaj   +1 more source

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

Molecules, 2014
A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones 2a–n.
Abdulrahman I. Almansour, Raju Suresh Kumar, Farzana Beevi, Amir Nasrolahi Shirazi, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Brian Sullivan, Kellen McCaffrey, Alaa Nahhas, Keykavous Parang, Mohamed Ashraf Ali   +11 more
doaj   +1 more source

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines [PDF]

, 2017
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia.
Cabrera, Maia Diana Eliana, Cardama, Georgina Alexandra, Davio, Carlos Alberto, Echeverría, Emiliana Beatriz, Fernandez, Natalia Cristina, González, Nazareno, Lorenzano Menna, Pablo, Remes Lenicov, Federico   +7 more
core   +2 more sources

Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
In our present research, we synthesised new thiazolidine-2,4-diones (12–28). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity.
Nazar Trotsko, Agata Przekora, Justyna Zalewska, Grażyna Ginalska, Agata Paneth, Monika Wujec   +5 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

Synthetic Derivatives of Vinpocetine as Antiproliferative Agents

Drugs and Drug Candidates
Background/Objectives: Vincamine is an indole alkaloid initially isolated from plants of the Vinca genus and has previously been demonstrated to have antioxidant, hypoglycemic, and hypolipidemic activities.
Mihira Gutti, Melanie Tsui, Stella Yang, Selina Xi, Jennifer Luo, Arshia Desarkar, Yining Xie, Mirabelle Feng, Udbhav Avadhani, Shloka Raghavan, Elena Brierley-Green, Erika Yu, Edward Njoo   +12 more
doaj   +1 more source

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling [PDF]

, 2014
Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process.
Alvarez-Buylla, Alvaro, Ana I. Santos, Ana S. Lourenço, António F. Ambrósio, Arvidsson, Bal-Price, Batchelor, Beckman, Beltran, Ben-Hur, Benraiss, Bergsland, Boje, Bruno P. Carreira, Buck, Butovsky, Cacci, Caetana M. Carvalho, Calabrese, Calabrese, Cappella, Carreira, Carreira, Chao, Chehrehasa, Covacu, Curtis, Davalos, Dawson, Dawson, Doetsch, Ekdahl, Ekdahl, Eriksson, Estrada, Gage, Galea, Giulian, Green, Guix, Hanafy, Ignarro, Inês M. Araújo, Iosif, Ischiropoulos, Keefer, Kempermann, Kettenmann, Keynes, Lane, Lowenstein, Madhusoodanan, Maria I. Morte, Matarredona, Ming, Misko, Moncada, Monje, Monje, Monteiro, Moreno-Lopez, Murillo-Carretero, Murillo-Carretero, Murphy, Nathan, Nimmerjahn, Ormerod, Packer, Parent, Pryor, Radi, Reynolds, Rock, Salvemini, Saura, Sierra, Szabo, Taupin, Torroglosa, Uc, Vallieres, Walton, Zhang, Zhang, Zhang   +85 more
core   +2 more sources