Results 61 to 70 of about 162,577 (262)

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources

Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

Molecules, 2015
The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined.
Juan C. Cedrón, Ángel G. Ravelo, Leticia G. León, José M. Padrón, Ana Estévez-Braun   +4 more
doaj   +1 more source

Antibacterial, Antiradical and Antiproliferative Potential of Green, Roasted, and Spent Coffee Extracts

Applied Sciences, 2022
The phytochemical compositions of green coffee beans (GB), roasted coffee (RC), and the solid residue known as spent coffee grounds (SCG) have been associated with beneficial physiological effects.
Gema C. Díaz-Hernández, Patricia Alvarez-Fitz, Yanik I. Maldonado-Astudillo, Javier Jiménez-Hernández, Isela Parra-Rojas, Eugenia Flores-Alfaro, Ricardo Salazar, Mónica Ramírez   +7 more
doaj   +1 more source

The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]

, 2013
Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Romero-Canelón, Isolda, Sadler, P. J., Salassa, Luca   +2 more
core   +1 more source

Antiproliferative Activity of Amathaspiramide Alkaloids and Analogs

CHEMICAL & PHARMACEUTICAL BULLETIN, 2016
Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results showed amathaspiramides A, C, and E had moderate antiproliferative activity.
Jun, Shimokawa, Koji, Chiyoda, Hirotatsu, Umihara, Tohru, Fukuyama   +3 more
openaire   +3 more sources

Enhanced and Selective Antiproliferative Activity of Methotrexate-Functionalized-Nanocapsules to Human Breast Cancer Cells (MCF-7)

Nanomaterials, 2018
Methotrexate is a folic acid antagonist and its incorporation into nanoformulations is a promising strategy to increase the drug antiproliferative effect on human breast cancer cells by overexpressing folate receptors.
Catiúscia P. de Oliveira, Sabrina L. Büttenbender, Willian A. Prado, Aline Beckenkamp, Ana C. Asbahr, Andréia Buffon, Silvia S. Guterres, Adriana R. Pohlmann   +7 more
doaj   +1 more source

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

Antioxidants, 2019
We present the synthesis of a range of benzimidazole/benzothiazole-2-carboxamides with a variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino protonated moieties, which were evaluated for their antiproliferative activity
Maja Cindrić, Irena Sović, Marija Mioč, Lucija Hok, Ida Boček, Petra Roškarić, Kristina Butković, Irena Martin-Kleiner, Kristina Starčević, Robert Vianello, Marijeta Kralj, Marijana Hranjec   +11 more
doaj   +1 more source

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

Phytochemical and Antiproliferative Activity of Proso Millet

PLoS ONE, 2014
The phytochemical content, antioxidant activity and antiproliferative properties of three diverse varieties of proso millet are reported. The free phenolic content ranged from 27.48 (Gumi 20) to 151.14 (Mi2504-6) mg gallic acid equiv/100 g DW. The bound phenolic content ranged from 55.95 (Gumi20) to 305.81 (Mi2504-6) mg gallic acid equiv/100 g DW.
Lizhen Zhang, Ruihai Liu, Wei Niu
openaire   +4 more sources

Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Although various dual-target tubulin inhibitors have been designed and synthesised, no dual tubulin-NEDDylation inhibitors as antiproliferative agents were reported so far.
Dong-Jun Fu, Ting Wang
doaj   +1 more source