Results 71 to 80 of about 162,577 (262)

Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries [PDF]

, 2011
<p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth ...
Baker, A.H., Biondi, G., Colombo, A., Di Lauro, M.V., Gordon, P., Grassia, G., Guglielmotti, A., Ialenti, A., Kennedy, S., Maddaluno, M., Maffia, P.   +10 more
core   +1 more source

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source

Antiproliferative, Antimicrobial and Apoptosis Inducing Effects of Compounds Isolated from Inula viscosa

Molecules, 2012
The antiproliferative and antimicrobial effects of thirteen compounds isolated from Inula viscosa (L.) were tested in this study. The antiproliferative activity was tested against three cell lines using the MTT assay. The microdilution method was used to
Wamidh H. Talib, Adel M. Mahasneh, Musa H. Abu Zarga   +2 more
doaj   +1 more source

Studies of the antitumor mechanism of action of dermaseptin B2, a multifunctional cationic antimicrobial peptide, reveal a partial implication of cell surface glycosaminoglycans.

PLoS ONE, 2017
Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo.
Célia Dos Santos, Sabah Hamadat, Karen Le Saux, Clara Newton, Meriem Mazouni, Loussiné Zargarian, Mickael Miro-Padovani, Patricia Zadigue, Jean Delbé, Yamina Hamma-Kourbali, Mohamed Amiche   +10 more
doaj   +1 more source

Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs [PDF]

, 1993
Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506.
Cramer, D, Demetris, AJ, Makowka, L, Murase, N, Starzl, TE, Tanabe, M, Valdivia, L   +6 more
core   +1 more source

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]

, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T., Kaspar, Felix, Klare, Hendrik F. T., Kurreck, Jens, Neubauer, Peter, Paulick, Katharina, Röhrs, Viola, Wagner, Anke, Westarp, Sarah, Yehia, Heba   +9 more
core   +1 more source

Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects

Molecules, 2013
Several diterpenes with the labdane skeleton show biological activity, including antiproliferative effects. Most of the research work on bioactive labdanes has been carried out on naturally occurring diterpenes and semisynthetic derivatives, but much ...
Guillermo Schmeda-Hirschmann, Marco Bastías, Cristina Theoduloz, Mariano Walter Pertino   +3 more
doaj   +1 more source

Anti-proliferative activity of silver nanoparticles

BMC Cell Biology, 2009
Background Nanoparticles possess exceptional physical and chemical properties which led to rapid commercialisation. Silver nanoparticles (Ag-np) are among the most commercialised nanoparticles due to their antimicrobial potential.
Hande M Prakash, AshaRani PV, Valiyaveettil Suresh   +2 more
doaj   +1 more source

Yeast-derived biosynthesis of silver/silver chloride nanoparticles and their antiproliferative activity against bacteria [PDF]

, 2016
Here, we provide the first evidence of yeast strains assisted Ag/AgCl-NPs production in vitro. The formed nanoparticles were characterized by spectroscopic and electron microscopy approaches. UV-vis supported the biosynthesis. TEM analysis evidenced that
Almeida-Paes, Rodrigo, de Souza, Wanderley, Eugenio, Mateus, Farina, Marcos, Frasés, Susana, Lemgruber, Leandro, Lima, Luís Maurício T.R., Müller, Nathalia, Sant'Anna, Celso   +8 more
core   +1 more source

Antiproliferative activity of arborescidine alkaloids and derivatives

European Journal of Medicinal Chemistry, 2009
Current issues in cancer research involve searching for novel anticancer compounds that can be used to regulate the cell cycle and lead to more effective treatments of tumors. In this study, it was hypothesized that possessing a cyclic alkaloid similar to harmine, arborescidines can disrupt the proliferative state of cancer cells and block the activity
Santos, Leonardo S., Theoduloz, Cristina, Pilli, Ronaldo A., Rodriguez, Jaime   +3 more
openaire   +6 more sources