Results 81 to 90 of about 162,577 (262)

Optimized synthesis and antiproliferative activity of desTHPdactylolides [PDF]

Bioorganic & Medicinal Chemistry, 2018
Dactylolide and certain analogues are attractive targets for study due to their structural resemblance to zampanolide, a very promising anticancer lead compound and a unique covalent-binding microtubule stabilizing agent. The primary goal of this project is identification and synthesis of simplified analogues of dactylolide that would be easier to ...
Guanglin, Chen, Rubing, Wang, Bao, Vue, Manee, Patanapongpibul, Qiang, Zhang, Shilong, Zheng, Guangdi, Wang, James D, White, Qiao-Hong, Chen   +8 more
openaire   +2 more sources

Analysis and Biological Evaluation of Arisaema Amuremse Maxim Essential Oil

Open Chemistry, 2019
The chemical composition and antitumor activity of essential oil were compared for four parts of the Arisaema Amuremse Maxim. Chemical constituent of essential oil in every parts of Arisaema Amuremse Maxim was identified by GC-MS analysis systematically.
Li Guiying, Jiang Yueyao, Li Yingjun, He Tong, Wang Ying, Ji Tianyi, Zhai Wanchen, Zhao Lichun, Zhou Xiaoping   +8 more
doaj   +1 more source

Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [PDF]

, 2019
In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
Amthauer, Holger, Jann, Henning, Kayser, Antonin, Roderburg, Christoph, Stueven, Anna Kathrin, Tacke, Frank, Wetz, Christoph, Wiedenmann, Bertram, Wree, Alexander   +8 more
core   +1 more source

Antiproliferative activity of Vallaris glabra Kuntze (Apocynaceae)

Pharmacognosy Magazine, 2014
Our earlier study on the antiproliferative (APF) activity of leaf extracts of ten Apocynaceae species showed that leaves of Vallaris glabra possessed strong and broad-spectrum properties.In this study, sequential extracts of leaves, flowers and stems, and fractions and isolated compounds from dichloromethane (DCM) leaf extract of V.
Wong, Siu Kuin, Lim, Yau Yan, Ling, Sui Kiong, Chiang Chan, Eric Wei   +3 more
openaire   +3 more sources

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells

Molecules, 2011
Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The
Héctor Carrasco Altamirano, Joan Villena García, Luis Espinoza Catalán, Iván Montenegro Venegas, Alejandro Madrid Villegas   +4 more
doaj   +1 more source

Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]

, 2009
The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Bruns, Christiane J., Fürst, Robert, Garczarczyk, Dorota, Ischenko, Ivan, Joore, Jos, Rothmeier, Andrea S., Vollmar, Angelika M., Zahler, Stefan   +7 more
core   +1 more source

Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds

Molecules, 2015
There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids ...
Adina-Elena Segneanu, Ioan Grozescu, Florentina Cziple, Daniel Berki, Daniel Damian, Cristina Mariana Niculite, Alexandru Florea, Mircea Leabu   +7 more
doaj   +1 more source

Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells [PDF]

, 2017
Indexación: Web of Science; Scopus.Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer ...
Arias, J.I., Iturriaga, M.P., Paredes, R., Torres, C.G.   +3 more
core   +1 more source

Therapeutic properties of some specific honey types [PDF]

Food and Feed Research
This paper examines the physicochemical characteristics, as well as the antioxidant, antibacterial, and antiproliferative effects, of several honey types that are commercially available but not typical of Serbia.
Sakač Marijana B., Jovanov Pavle, Marić Aleksandar, Plavšić Dragana, Jakimov Dimitar, Đermanović Branislava   +5 more
doaj   +1 more source