Special Issue “Drug Discovery of Antiprotozoal Agents” [PDF]
PharmaceuticalsProtozoal diseases, such as leishmaniasis, malaria, African sleeping sickness, Chagas disease, amoebiasis, giardiasis, cryptococcosis, and toxoplasmosis (among others), affect and/or have the potential to infect more than one billion people worldwide [...
Francisco Jaime Bezerra Mendonça-Junior
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Design, Synthesis and Biological Evaluation of 2-(2-Amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as Antiprotozoal Agents [PDF]
Molecules, 2017 Parasitic diseases are a public health problem affecting millions of people worldwide. One of the scaffolds used in several drugs for the treatment of parasitic diseases is the benzimidazole moiety, a heterocyclic aromatic compound.
Emanuel Hernández-Núñez +5 more
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Mining Sudanese Medicinal Plants for Antiprotozoal Agents [PDF]
Frontiers in Pharmacology, 2020 Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria.
Abdelhalim Babiker Mahmoud +9 more
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Consumption Trends of Antifungal and Antiprotozoal Agents for Human Systemic Use in Kazakhstan from 2017 to 2023 [PDF]
AntibioticsBackground/Objectives: While multiple studies have investigated antibiotic consumption rates, there are few studies on the consumption of systemic antifungals and antiprotozoals.
Yuliya Semenova +5 more
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano +13 more
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy [PDF]
PharmaceuticalsPlasmodium, Leishmania, and Trypanosoma parasites are responsible for infectious diseases threatening millions of people worldwide. Despite more recent efforts devoted to the search for new antiprotozoal agents, efficacy, safety, and resistance issues ...
Alessandro Giraudo +5 more
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Natural marine products as antiprotozoal agents against amitochondrial parasites [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2022 The goal of this work is to compile and discuss molecules of marine origin reported in the scientific literature with anti-parasitic activity against Trichomonas, Giardia, and Entamoeba, parasites responsible for diseases that are major global health ...
Edgar Antonio Estrella-Parra +10 more
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New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation [PDF]
Journal of Chemistry, 2021 Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3 ...
Mohamed A. Abdelgawad +12 more
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Recent Advances in the Discovery of Novel Antiprotozoal Agents [PDF]
Molecules, 2019 Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people
Seong-Min Lee +3 more
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Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents [PDF]
Molecules, 2019 Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis ...
Anastasia L. Khandazhinskaya +13 more
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