Results 31 to 40 of about 7,779 (200)
Molecules, 2014 Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries.
Ramiro Quintanilla-Licea +6 more
doaj +1 more source
Anti-BioEn: An advanced framework for accurate bioactive agent classification based on hybrid models and graph feature encoding method [PDF]
BIO Web of ConferencesBioactive agents are compounds that have an influence on human beings, organs, or tissues. These agents, which might be found in both natural and synthetic chemicals, are able to interact with biological systems and produce a variety of therapeutic or ...
Shaon Shazzad Hossain +3 more
doaj +1 more source
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Marine Drugs, 2013 Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser +4 more
doaj +1 more source
Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [PDF]
Proceedings of the National Academy of Sciences, 1996 A novel fungal metabolite, apicidin [cyclo( N - O -methyl- l -tryptophanyl- l -isoleucinyl- d -pipecolinyl- l -2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity
Sandra J. Darkin‐Rattray +14 more
openalex +4 more sources
Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles
ChemistryOpen, 2021 A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa +9 more
doaj +1 more source
Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents
European Journal of Medicinal Chemistry, 2020 Malaria and tuberculosis are still among the leading causes of death in low-income countries. The 1,4-naphthoquinone (NQ) scaffold can be found in a variety of anti-infective agents. Herein, we report an optimised, high yield process for the preparation of various 2-arylnaphthoquinones by a palladium-catalysed Suzuki reaction. All synthesised compounds
Marc-Manuel Kalt +7 more
openalex +5 more sources
Antiprotozoal Nor-Triterpene Alkaloids from Buxus sempervirens L.
Antibiotics, 2021 Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents.
Lara U. Szabó +3 more
doaj +1 more source
Molecules, 2021 Betulinic acid (BA, 3β-hydroxy-lup-20(29)-en-28-oic acid) is a pentacyclic triterpene acid present predominantly in Betula ssp. (Betulaceae) and is also widely spread in many species belonging to different plant families.
André Barreto Cunha +3 more
doaj +1 more source
Symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems
Beilstein Journal of Organic Chemistry, 2010 We present the synthesis and selected physicochemical properties of several novel symmetrical and unsymmetrical α,ω-nucleobase mono- and bis-amide conjugated systems containing aliphatic, aromatic or saccharidic linkages. The final stage of the synthesis
Sławomir Boncel +4 more
doaj +1 more source
Identification of Antiprotozoal Compounds from Buxus sempervirens L. by PLS-Prediction
Molecules, 2021 Various nor-triterpene alkaloids of Buxus (B.) sempervirens L. have shown remarkable in vitro activity against the causative agents of tropical malaria and East African sleeping sickness.
Lara U. Szabó +3 more
doaj +1 more source