Results 111 to 120 of about 3,362,668 (327)

Developing a Trauma Checklist for People With a Learning Disability Accessing Community Health and Support Services

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background Research suggests people with a learning disability experience high prevalence of adverse life events which may result in trauma‐related mental health conditions. Identifying trauma‐related mental health conditions can facilitate access to support, however research suggests they may be under‐identified in this group. The aim of this
Sarah Wigham, Arman Iranpour, John L. Taylor, Claire Hills‐Wilson, Pamela Reitemeier, Katharine Petersen, Iain McKinnon, Simon S. Hackett   +7 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Impact of Early Antipsychotic Prescription Choice on Weight Gain in the First 5 Years of Psychotic Illness: a Retrospective Cohort Study

Neurology and Therapy
Introduction We analysed the effects of antipsychotic drug prescribing in year 1 of treatment for psychosis on future weight gain over 5 years. Methods We studied how weight changed over 5 years after the first diagnosis of psychosis/schizophrenia ...
Adrian Heald, George Tilston, John Julian Warner-Levy, Loren Wilkins, Richard Williams, Toby Pillinger, William Deakin, Damien Longson, Lamiece Hassan, Caroline Dalton, Gavin P. Reynolds, Joseph Firth   +11 more
doaj   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Acute mania and psychosis potentially triggered by St John's wort. [PDF]

PCN Rep
Abstract Background St John's wort (SJW) is widely used as an herbal supplement for depressive symptoms and is generally regarded as safe. However, although extremely rare, manic and psychotic reactions have been reported, typically in individuals taking high doses, using psychotropic agents, or having a psychiatric history. Case Presentation We report
Yoshioka D, Yamanashi T, Iwata M.
europepmc   +2 more sources

Supplemental Figure S1 from Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis

, 2023
Alok Ranjan, Parul Gupta, Sanjay K. Srivastava   +2 more
openalex   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Safety and tolerability of antipsychotics: focus on amisulpride

Drug, Healthcare and Patient Safety, 2010
Mario F Juruena1, Eduardo Pondé de Sena2, Irismar Reis de Oliveira31Stress and Affective Disorders Programme, Department of Neuroscience and Behaviour, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil ...
Mario F Juruena, Eduardo Pondé de Sena, Irismar Reis de Oliveira   +2 more
doaj