Results 81 to 90 of about 96,867 (352)

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Olanzapine-induced skin eruptions

Indian Journal of Psychological Medicine, 2017
Adverse cutaneous reactions are known to occur with psychotropic medications, which may lead to poor drug compliance. As compared to other group of psychotropics, there is relatively scarce literature on olanzapine-induced skin eruptions.
Nishtha Chawla, Saurabh Kumar, Yatan Pal Singh Balhara   +2 more
doaj   +1 more source

The side effect profile of Clozapine in real world data of three large mental hospitals [PDF]

, 2020
Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control trials (RCTs). We Propose a text mining approach to detect adverse events and medication episodes from the clinical text to enhance our ...
arxiv   +1 more source

Parkinsonian motor impairment predicts personality domains related to genetic risk and treatment outcomes in schizophrenia [PDF]

, 2017
Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for
Alemán, Gabriela González, Balda, Mara, Bourdieu, Mercedes, Calvó, María, Cloninger, C. Robert, Conesa, Horacio A, de Erausquin, Gabriel A, Escobar, Javier I, Florenzano, Néstor V, Guerrero, Gonzalo, Kamis, Danielle, Molina, Juan L, Padilla, Eduardo, Rangeon, Beatriz Molina, Strejilevich, Sergio A, Zwir, Igor   +15 more
core   +2 more sources

Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 111-119, January 2023., 2023
Abstract Information regarding deaths caused by poisoning or adverse effects of medication in Danish persons not using illicit narcotic drugs (PNUIDs) is sparse. To characterize aetiology, demographics, and death scene, we reviewed all legal autopsies performed at Aarhus University from 2017 to 2019 and isolated 96 deaths caused by medications in ...
Charlotte U. Andersen, Hafsa Ahmed, Mathias Rædkjær, Jørgen B. Hasselstrøm, Maiken K. Larsen   +4 more
wiley   +1 more source

Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study. [PDF]

, 2014
AIM: Antipsychotics increase the risk of stroke. Their effect on myocardial infarction remains uncertain because people prescribed and not prescribed antipsychotic drugs differ in their underlying vascular risk making between-person comparisons difficult
Anaya-Izquierdo, Karim, Brauer, Ruth, Denaxas, Spiros C, Douglas, Ian, Farrington, C Paddy, Hemingway, Harry, Smeeth, Liam, Timmis, Adam, Whitaker, Heather   +8 more
core   +2 more sources

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Use of benzodiazepines and benzodiazepine‐related drugs in the Nordic countries between 2000 and 2020

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 60-70, January 2023., 2023
Abstract Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ‐sedatives, BZ‐hypnotics, and benzodiazepine‐related drugs (BZRD) in adults (≥20 years) were obtained from ...
Mikkel Højlund, Larus S. Gudmundsson, Jacob H. Andersen, Leena K. Saastamoinen, Helga Zoega, Svetlana O. Skurtveit, Jonas W. Wastesson, Jesper Hallas, Anton Pottegård   +8 more
wiley   +1 more source

Designing drug regimens that mitigate nonadherence [PDF]

arXiv, 2021
Medication adherence is a well-known problem for pharmaceutical treatment of chronic diseases. Understanding how nonadherence affects treatment efficacy is made difficult by the ethics of clinical trials that force patients to skip doses of the medication being tested, the unpredictable timing of missed doses by actual patients, and the many competing ...
arxiv  

Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report [PDF]

, 2012
Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition.
AL Pelonero, BD Berman, D Berardi, D Bereardi, D Heyland, Daniel J Smith, Daniel Martin, F-GB Pajonk, H Itoh, J Ananth, J Delay, J Gill, JF Patterson, JN Trollor, JR Strawn, Julie Langan, K Otani, KL Hall, LF Viejo, LS Friedman, M Dave, MJ Bhanushali, P Adnet, P Sachdev, P Sachdev, PE Keek, PF Buckley, PI Rosebush, PJ Alexander, Polash Shajahan, RJ Gurrera, RJ Gurrera, RW Baker, S Caroff, S Madakasira   +34 more
core   +3 more sources