Results 51 to 60 of about 1,671 (202)

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

New Antithrombotic Drugs in Acute Coronary Syndromes: the Role of Fondaparinux and Bivalirudin in Reducing Major Hemorrhages and Mortality [PDF]

, 2009
Two newer antithrombins have recently been tested for efficacy and safety in the treatment of acute coronary syndromes (ACS), an indirect antithrombin, fondaparinux, a synthetic pentasacharide with anti-Xa properties, and a direct thrombin inhibitor ...
Pipilis, Athanasios G
core   +2 more sources

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Influence of patient factors on target plasma volume treated attainment rate during double filtration plasmapheresis in patients with hypertriglyceridemic acute pancreatitis

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley   +1 more source

Role of Physical Therapists in the Management of Individuals at Risk for or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline [PDF]

, 2016
The American Physical Therapy Association (APTA), in conjunction with the Cardiovascular & Pulmonary and Acute Care sections of APTA, have developed this clinical practice guideline to assist physical therapists in their decision-making process when ...
Auten, Beth, Frese, Ethel M., Hillegass, Ellen, Puthoff, Michael, Sobush, Dennis, Thigpen, Mary   +5 more
core   +1 more source

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source

Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition [PDF]

, 2007
Blood clotting proceeds through the sequential proteolytic activation of a series of serine proteases, culminating in thrombin cleaving fibrinogen into fibrin.
Camacho, Laureano O., Church, Frank C., Cooper, Scott T., Gonzales, Patrick R., Kielar, Dana M., Rezaie, Alireza R., Walston, Timothy D.   +6 more
core   +2 more sources

Temperature-responsive release of thyroxine and its environmental adaptation in Australians. [PDF]

, 2014
The hormone thyroxine that regulates mammalian metabolism is carried and stored in the blood by thyroxine-binding globulin (TBG). We demonstrate here that the release of thyroxine from TBG occurs by a temperature-sensitive mechanism and show how this ...
Carrell, Robin W, Chan, Wee Lee, Qi, Xiaoqiang, Read, Randy J, Zhou, Aiwu   +4 more
core   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Technical Specification for Hemocompatibility Assessment of Human Mesenchymal Stem Cells

Cell Proliferation, EarlyView.
A comprehensive evaluation of MSC haemocompatibility is a critical prerequisite for ensuring the safety of systemic delivery. A haemocompatibility level of ‘poor’ indicates a high probability of adverse blood reactions when MSCs contact with blood. ABSTRACT ‘Technical specification for haemocompatibility assessment of human mesenchymal stem cells’ is ...
Jialing Liu, Weiyang Liang, Wenjie Xia, Ping Wang, Jie Hao, Tao Na, Sunxing Yan, Yu Zhang, Ka Li, Qiyuan Li, Guangjin Pan, Jun Wei, Qubo Chen, Jiani Cao, Peijun Zhai, Boqiang Fu, Hengjun Gao, Yong Zhang, Lei Wang, Meimei Guo, Shijun Hu, Lijun Zhu, Yang Zhao, Weiqi Zhang, Zhihong Wu, Yifang Ping, Hongling Zhao, Shuaishuai Niu, Tongbiao Zhao, Aijin Ma, Andy Peng Xiang, Xiaoyong Chen   +31 more
wiley   +1 more source