Results 61 to 70 of about 1,433 (211)

The effect of anticoagulation with subcutaneously delivered polyethylene glycol conjugated hirudin and recombinant tissue plasminogen activator on recurrent stenosis in the rabbit double-balloon injury model

, 2004
Myointimal hyperplasia is the condition usually responsible for recurrent stenosis (restenosis) after endarterectomy, bypass grafting and angioplasty. Its cause is still not known.
Smith, A, Alexander, B, Burnand, K G, Humphries, J, Lattimer, C L, Eastham, D, Gaffney, P J   +6 more
core   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 745-768, July/August 2026.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 800-828, July/August 2026.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Phylogenomics of vertebrate serpins

, 2010
Kumar A. Phylogenomics of vertebrate serpins. Bielefeld (Germany): Bielefeld University; 2010.The serpins constitute a superfamily of proteins that fold into a conserved tertiary structure and employ a sophisticated, irreversible suicide-mechanism of ...
Kumar, Abhishek
core  

Effect of nonspecific binding to plasma proteins on the antithrombin activities of unfractionated heparin, low-molecular-weight heparin, and dermatan sulfate

, 1997
Background: Nonspecific binding to plasma proteins decreases the anti- factor Xa (anti-Xa) activity of unfractionated heparin (UFH) but not that of low-molecular-weight heparin (LMWH).
Hirsh J., Young E., Weitz J. I., Cosmi B., Rischke J., Fredenburgh J. C.   +5 more
core   +1 more source

Variability in ACT Response to Standard UFH Bolus During PCI: A Prospective Study on Determinants of Subtherapeutic Anticoagulation

Catheterization and Cardiovascular Interventions, Volume 107, Issue 7, Page 2293-2303, June 1, 2026.
ABSTRACT Background Unfractionated heparin (UFH) remains the standard anticoagulant during percutaneous coronary intervention (PCI), with guidelines recommending a target activated clotting time (ACT) of ≥250 s. However, despite receiving a standardized bolus dose, many patients fail to achieve this target.
Manh Cuong Vu, Antonin Trimaille, Amandine Granier, Adrien Carmona, Anis Elidrissi, Marion Kibler, Laurence Jesel, Patrick Ohlmann, Laurent Sattler, Olivier Morel   +9 more
wiley   +1 more source

［総説］Rational Design to Develop Antithrombotic Drugs from the Relationship between the Structure and Function of $ \alpha $ thrombin [PDF]

Many protease inhibitors in the circulating blood inhibit the activity of $ \alpha $-thrombin. Inhibition of $ \alpha $-thrombin by antithrombins is attributable to the characteristics of structural relationships between $ \alpha $-thrombin and ...
Yoshioka, Miwa, Kosugi, Tadayoshi, Nakamura, Mariko, Takara, Shigeru, Nakamura, Kazunao, Sunagawa, Masanori, Nakasone, Toshiyuki, Shimada, Seiji, Kimura, Yasutaka, Tengan, Hiroatsu, Uehara, Ken, Motomura, Makoto, Tamaki, Minao, Ohta, Shigeto, Bae, Maen   +14 more
core  

Forgotten Steps in the Coagulation Cascade

Haemophilia, EarlyView.
Quentin Van Thillo, Cedric Hermans
wiley   +1 more source

Neonatal Wet Gangrene With Early Auto‐Amputation in a Resource‐Limited Setting With Incomplete Etiologic Workup: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Neonatal limb gangrene with auto‐amputation is rare and often idiopathic. Early recognition, prompt referral, and thorough etiologic workup—despite resource limitations—are critical. Wet gangrene requires broad‐spectrum antibiotics, wound care, and timely surgical amputation to preserve growth plates and allow future prosthesis fitting.
Milki Tufa Feyisa, Beza Eshetu, Tolosa Dibisa, Mulatu Gshaw, Birhanu Tolera, Endalew Dessie Birara, Adugna Lamessa, Tamirat Godebo Woyimo   +7 more
wiley   +1 more source

Stroke Risk and Antithrombotic Strategies in Atrial Fibrillation

, 2010
Background and Purpose— Although the stroke rate associated with atrial fibrillation has declined over the last 10 years, the emerging atrial fibrillation epidemic threatens to increase the incidence ...
Graeme J. Hankey, Saul B. Freedman, Caroline Medi   +2 more
core   +1 more source