Results 131 to 140 of about 2,581 (172)

Antitrypanosomal Chloronitrobenzamides

Journal of Medicinal Chemistry
Human African trypanosomiasis (HAT), a neglected tropical disease caused by Trypanosoma brucei gambiense (Tbg) or Trypanosoma brucei rhodesiense (Tbr), remains a significant public health concern with over 55 million people at risk of infection. Current treatments for HAT face the challenges of poor efficacy, drug resistance, and toxicity.
Angela K. Carrillo, Tara Man Kadayat, Jong Yeon Hwang, Yizhe Chen, Fangyi Zhu, Gloria Holbrook, Kirsten Gillingwater, Michele C. Connelly, Lei Yang, Marcel Kaiser, R. Kiplin Guy   +10 more
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Antitrypanosomal Lactones from Nectandra barbellata

Journal of Natural Products, 2021
Twigs of Nectandra barbellata were extracted using a solution of the ionic liquid 1-butyl-3-methylimidazolium bromide (BMImBr) in H2O, assisted by microwave (MAE). After successive chromatographic steps, one sesquiterpene, costic acid, and three new related lactones, (R)-3(7)-Z-3-hexadec-21-enylidene-5-(hydroxymethyl)tetrahydrofuran-2-one (1), (R)-3(7)-
Vinicius S. Londero, Thais A. Costa-Silva, Guilherme M. Antar, João B. Baitello, Larissa V. F. de Oliveira, Fernanda F. Camilo, Andrea N. L. Batista, Joao M. Batista, Andre G. Tempone, Joao Henrique G. Lago   +9 more
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2-Arylpaullones are selective antitrypanosomal agents

European Journal of Medicinal Chemistry, 2013
Antileishmanial paullone-chalcone hybrid molecules display antiparasitic activity against Trypanosoma brucei rhodesiense blood stream forms, albeit with low selectivity against human THP-1 cells. In order to develop less toxic analogues, paullones with acrylamide or aryl substituents in 2-position were synthesized, of which the latter exhibited potent ...
Jasmin, Ryczak, Ma'ayan, Papini, Annette, Lader, Abedelmajeed, Nasereddin, Dmitry, Kopelyanskiy, Lutz, Preu, Charles L, Jaffe, Conrad, Kunick   +7 more
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Antiplasmodial and Antitrypanosomal Activity of Pyrethrins and Pyrethroids

Journal of Agricultural and Food Chemistry, 2011
In a screen of 1800 plant and fungal extracts for antiplasmodial, antitrypanosomal, and leishmanicidal activity, the n-hexane extract of Chrysanthemum cinerariifolium (Trevir.) Vis. flowers showed strong activity against Plasmodium falciparum. We isolated the five pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and
Hata, Y., Zimmermann, S., Quitschau, M., Kaiser, M., Brun, R., Hamburger, M., Adams, M.   +6 more
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Antidesmone, a novel antitrypanosomal alkaloid

Pharmaceutical and pharmacological letters, 2001
Antidesmone, a novel acetogenic quinolone alkaloid from the African shrub Antidesma membranaceum, has been found to exhibit potent antitrypanosomal activity against Trypanasoma cruzi, the pathogenic agent of Chagas disease. The activity seems to be highly selective, being much larger than that towards other protozoan parasites causing tropical diseases.
Bringmann, G., Schlauer, J., Rischer, Heiko, Wohlfarth, M., Haller, R., Bär, S., Brun, R.   +6 more
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Antitrypanosomal activity of quaternary naphthalimide derivatives

Bioorganic & Medicinal Chemistry Letters, 2007
Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and ...
Mathias, Muth, Verena, Hoerr, Melanie, Glaser, Alicia, Ponte-Sucre, Heidrun, Moll, August, Stich, Ulrike, Holzgrabe   +6 more
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Antitrypanosomal effect of the aqueous extract of Brassica oleracea

Fìtoterapìâ, 2002
The in vitro antitrypanosomal activity of the aqueous extract of Brassica oleracea, was investigated in Trypanosoma brucei brucei 'Lafia' strain. The extract was found to be effective by immobilizing the trypanosomes within the 3-h incubation period and thereafter rendering them not infective to mice.
F K Okwuasaba
exaly   +3 more sources

Antitrypanosomal Cycloartane Glycosides fromAstragalus baibutensis

Chemistry & Biodiversity, 2006
Baibutoside (5), a new cycloartane-type triterpene glycoside, has been isolated from the roots of Astragalus baibutensis along with four known glycosides, acetylastragaloside I (1), and astragalosides I, II, and IV (2-4, resp.). The structure elucidation of the compounds were achieved by a combination of one- and two-dimensional NMR techniques (DQF ...
Ihsan, Caliş, Semra, Koyunoğlu, Akgül, Yeşilada, Reto, Brun, Peter, Rüedi, Deniz, Taşdemir   +5 more
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Trypanothione as a Target in the Design of Antitrypanosomal and Antileishmanial Agents

Current Pharmaceutical Design, 2001
Trypanothione is the key molecule in the defence mechanism of Trypanosoma and Leishmania against oxidative stress. The uniqueness of trypanothione makes the metabolism of this molecule an attractive target in antitrypanosomal and antileishmanial drug design. It became clear that this antioxidant cascade can be considered as the "Achilles heel" of these
Augustyns, K., Amssoms, K., Yamani, A., Rajan, P.K., Haemers, A.   +4 more
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Antitrypanosomal agents: treatment or threat?

The Lancet, 2010
768 www.thelancet.com Vol 376 September 4, 2010 Authors’ reply Allergic dermatitis, the most common adverse eff ect of benznidazole, is selflimiting, usually of mild-to-moderate intensity, easily manageable with corticosteroids, and in most patients does not require interruption of therapy.
Victor Sarli Issa, Edimar Alcides Bocchi
openaire   +1 more source