Results 1 to 10 of about 2,263 (168)

Salvia officinalis L.: Antitrypanosomal Activity and Active Constituents against Trypanosoma brucei rhodesiense [PDF]

Molecules, 2021
As part of our studies on antiprotozoal activity of approved herbal medicinal products, we previously found that a commercial tincture from Salvia officinalis L. (common Sage, Lamiaceae) possesses high activity against Trypanosoma brucei rhodesiense (Tbr)
Núria Llurba Montesino, Marcel Kaiser, Pascal Mäser, Thomas J. Schmidt   +3 more
doaj   +2 more sources

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones. [PDF]

PLoS ONE, 2023
Severe infections with potentially fatal outcomes are caused by parasites from the genera Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote areas in the tropics and subtropics with limited access to adequate health ...
Irina Ihnatenko, Marco J Müller, Oliver C F Orban, Jens C Lindhof, Diego Benítez, Cecilia Ortíz, Estefanía Dibello, Leonardo L Seidl, Marcelo A Comini, Conrad Kunick   +9 more
doaj   +2 more sources

Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling [PDF]

Antibiotics, 2020
In the present study, we investigated the actinomycetes associated with the Red Sea-derived soft coral Sarcophyton glaucum in terms of biological and chemical diversity. Three strains were cultivated and identified to be members of genera Micromonospora,
Noha M. Gamaleldin, Walid Bakeer, Ahmed M. Sayed, Yara I. Shamikh, Ahmed O. El-Gendy, Hossam M. Hassan, Hannes Horn, Usama Ramadan Abdelmohsen, Wael N. Hozzein   +8 more
doaj   +2 more sources

Nitroquinolones and nitroquinolines: syntheses and antitrypanosomal activity. [PDF]

Mol Divers
Nitroaromatic small molecules are established anti-infectives, including against trypanosomal diseases. Inspired by our previously identified suicide inhibitors of Mycobacterium tuberculosis (Mtb) decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1), we report the synthesis and in vitro antitrypanosomal activity of six novel nitroquinoline derivatives (
Dube PS, Francisco KR, Legoabe LJ, Sun YU, Kaur Y, Nguyen TP, Caffrey CR, Beteck RM.   +7 more
europepmc   +3 more sources

In vitro and in vivo antitrypanosomal activity of the fresh leaves of Ranunculus Multifidus Forsk and its major compound anemonin against Trypanosoma congolense field isolate [PDF]

BMC Veterinary Research
Background Animal trypanosomiasis is a major livestock problem due to its socioeconomic impacts in tropical countries. Currently used trypanocides are toxic, expensive, and the parasites have developed resistance to the existing drugs, which calls for an
Betelhem Sirak, Gizachew Kassahun Bizuneh, Peter Imming, Kaleab Asres   +3 more
doaj   +2 more sources

Enantiospecific antitrypanosomal in vitro activity of eflornithine.

PLoS Neglected Tropical Diseases, 2021
The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage.
Mikael Boberg, Monica Cal, Marcel Kaiser, Rasmus Jansson-Löfmark, Pascal Mäser, Michael Ashton   +5 more
doaj   +4 more sources

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From <i>Lobelia rhynchopetalum</i> Hemsl. Root Extract Against <i>Trypanosoma congolense</i> Field Isolates. [PDF]

Biomed Res Int
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Yimer S, Tewelde E, Bisrat D, Tadesse S, Yeshak MY.   +4 more
europepmc   +2 more sources

Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity. [PDF]

RSC Med Chem, 2020
Structure–property and structure–activity studies identify regions that positively modulate aqueous solubility; though maintaining potent anti-trypanosomal potency proves challenging.
Klug DM, Diaz-Gonzalez R, DeLano TJ, Mavrogiannaki EM, Buskes MJ, Dalton RM, Fisher JK, Schneider KM, Hilborne V, Fritsche MG, Simpson QJ, Tear WF, Devine WG, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Bosch-Navarrete C, Ruiz-Pérez LM, Gamarro F, González-Pacanowska D, Martinez-Martinez MS, Manzano-Chinchon P, Navarro M, Pollastri MP, Ferrins L.   +24 more
europepmc   +5 more sources

Structure-Activity Relationship Study of Sesquiterpene Lactones and Their Semi-Synthetic Amino Derivatives as Potential Antitrypanosomal Products

Molecules, 2014
Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis.
Stefanie Zimmermann, Gerda Fouché, Maria De Mieri, Yukiko Yoshimoto, Toyonobu Usuki, Rudzani Nthambeleni, Christopher J. Parkinson, Christiaan van der Westhuyzen, Marcel Kaiser, Matthias Hamburger, Michael Adams   +10 more
doaj   +3 more sources

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Borges GK, Das Neves GB, Reichardt L, Costa UMD, Miletti LC, Bastos-Pereira AL.   +5 more
europepmc   +2 more sources