Results 21 to 30 of about 2,263 (168)
Journal of Chemistry, 2022 The most common diseases that affect low-income countries are helminthosis and trypanosomosis. In Ghana, and in many other African countries, herbal treatment of various diseases is still common.
Ahmed Wahab Obeng +8 more
doaj +1 more source
Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid
Elizabeth, Nenortas +3 more
openaire +2 more sources
Open Veterinary Science, 2022 This study investigated the antitrypanosomal activity of Argemone mexicana extract and fractions in the animal model of Trypanosoma brucei brucei infection.
Chukwu Ifeoma L. +5 more
doaj +1 more source
Evaluation of quinolone derivatives for antitrypanosomal activity [PDF]
Tropical Medicine & International Health, 2001 About 160 fluoroquinolones and derivatives were tested for antitrypanosomal activity in a drug sensitivity assay followed by fluorometric evaluation. The most active quinolone compounds had IC50 values in the range from 100 to 900 ng/ml, while several derivatives were not active at a concentration of 100 μg/ml.
Keiser J, Burri C
openaire +3 more sources
Histopathological Studies on the Curative Role of Mentha longifolia in Trypanosoma evansi Experimentally Infected Rats [PDF]
Journal of Veterinary Medical Research, 2020 Trypanosomiasis is an important protozoan disease of domestic animals and man. One of the important pathogenic trypanosomes in animals is Trypanosoma evansi; the causative agent of Surra that is highly fatal to a number of domesticated mammals such as ...
Rasha Mohamed
doaj +1 more source
Molecules, 2022 New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials ...
Darline Dize +12 more
doaj +1 more source
Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles
Molecules, 2020 A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions.
Matshawandile Tukulula +3 more
doaj +1 more source
Ergostane-Type Sterols From Several Strains
Natural Product Communications, 2022 Ergosterol is an essential component for fungi, including entomopathogenic fungi like Cordyceps . Cordyceps has been used as a traditional medicine in Japan and China and possesses various unique ergostane-type sterols, those exhibit bioactivities.
Tatsuro Yoneyama +5 more
doaj +1 more source
Antitrypanosomal Activity of Sinefungin
The American Journal of Tropical Medicine and Hygiene, 1983 Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense.
Dube, D.K. +4 more
openaire +2 more sources
Molecules, 2018 As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena ...
Charles Okeke Nnadi +3 more
doaj +1 more source