Results 41 to 50 of about 2,263 (168)

Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent

Molecules, 2018
The Latin American plant Tabernaemontana longipes was studied in this work as a potential source of antiparasitic agents. The chloroform extract of T. longipes leaves was separated into several fractions, and tested for antitrypanosomal activity.
Simira Carothers, Rogers Nyamwihura, Jasmine Collins, Huaisheng Zhang, HaJeung Park, William N. Setzer, Ifedayo Victor Ogungbe   +6 more
doaj   +1 more source

Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities

Molecules, 2018
This paper provides a comparative account of the essential oil chemical composition and biological activities of five Brazilian species of Baccharis (Asteraceae), namely B. microdonta, B. pauciflosculosa, B. punctulata, B.
Jane M. Budel, Mei Wang, Vijayasankar Raman, Jianping Zhao, Shabana I. Khan, Junaid U. Rehman, Natascha Techen, Babu Tekwani, Luciane M. Monteiro, Gustavo Heiden, Inês J. M. Takeda, Paulo V. Farago, Ikhlas A. Khan   +12 more
doaj   +1 more source

Antineoplastic and Antitrypanosomal Properties of Propolis from Tetragonula biroi Friese

Molecules, 2022
Propolis, popularly known as bee glue, is a resinous, sticky substance produced by different bee species across the globe. Studies on the biological properties of propolis from the Philippines are rare.
Samyah Alanazi
doaj   +1 more source

Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

Marine Drugs, 2014
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol.
Christina Viegelmann, Jennifer Parker, Thengtheng Ooi, Carol Clements, Gráinne Abbott, Louise Young, Jonathan Kennedy, Alan D. W. Dobson, RuAngelie Edrada-Ebel   +8 more
doaj   +1 more source

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

Molecules, 2015
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah   +4 more
doaj   +1 more source

The Alkaloid-Enriched Fraction of Pachysandra terminalis (Buxaceae) Shows Prominent Activity against Trypanosoma brucei rhodesiense

Molecules, 2021
In the course of our studies on antiprotozoal natural products and following our recent discovery that certain aminosteroids and aminocycloartanoid compounds from Holarrhena africana A. DC. (Apocynaceae) and Buxus sempervirens L. (Buxaceae), respectively,
Dagmar Flittner, Marcel Kaiser, Pascal Mäser, Norberto P. Lopes, Thomas J. Schmidt   +4 more
doaj   +1 more source

New 2-aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities [PDF]

Monatshefte für Chemie - Chemical Monthly, 2020
Abstract Novel 2-aminopyrimidine derivatives were prepared from acyclic starting materials, benzylidene acetones and ammonium thiocyanates, via 5 steps, including ring closure, aromatization, S-methylation, oxidation to methylsulfonyl compounds, and formation of guanidines with suitable amines.
Michael Hoffelner, Usama Hassan, Werner Seebacher, Johanna Dolensky, Patrick Hochegger, Marcel Kaiser, Pascal Mäser, Robert Saf, Robert Weis   +8 more
openaire   +2 more sources

New lignan glycosides from Justicia secunda Vahl (Acanthaceae) with antimicrobial and antiparasitic properties

Heliyon, 2023
Three new lignan glucosides, namely, justisecundosides A (1), B (2a), and C (2b), were isolated from the whole plant of Justicia secunda together with seven known compounds (3−9).
Viviane Flore Kamlo Kamso, Yanick Kevin Dongmo Melogmo, Billy Toussie Tchegnitegni, Mariscal Brice Tchatat Tali, Darline Dize, Cyrille Njampa Ngansop, Pantaléon Ambassa, Judith Laure Ouete Nantchouang, Ingrid Simo Konga, Fabrice Fekam Boyom, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso   +11 more
doaj   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Phytochemical Analysis, Cytotoxicity, and Antitrypanosomal, Antioxidant, and Anti-Inflammatory Activities of Clausena anisata Fruit, Azadirachta indica Leaf, and Stem Bark Extracts

Journal of Parasitology Research
Human African trypanosomiasis (HAT) is an infectious disease which kills humans and animals as a result of hematological distortions, oxidative stress, tissue and neuroinflammations. This study reports on the differences in cytotoxicity, antitrypanosomal,
Emmanuel Kofi Kumatia, Felix Kwame Zoiku, Prince Kyei Baffour, Anne Boakyewaa Anokye-Kumatia, Alex Asase   +4 more
doaj   +1 more source