Results 61 to 70 of about 2,263 (168)

Cinnamoylphenethyl Amides from Possess Anti-Trypanosomal Activity

Natural Product Communications, 2012
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC 50 =3.7 μg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides,
Fahimeh Moradi-Afrapoli, Nargues Yassa, Stefanie Zimmermann, Soodabeh Saeidnia, Abbas Hadjiakhoondi, Samad N. Ebrahimi, Matthias Hamburger   +6 more
doaj   +1 more source

Synthesis of lupeol derivatives and their antileishmanial and antitrypanosomal activities

Natural Product Research, 2017
The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2–11 were prepared by classical procedures.
Vanessa R, Machado, Louis P, Sandjo, Giovanni L, Pinheiro, Milene H, Moraes, Mario, Steindel, Moacir G, Pizzolatti, Maique W, Biavatti   +6 more
openaire   +2 more sources

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, Volume 109, Issue 5, May 2026.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source

In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract [PDF]

Research in Veterinary Science, 2015
The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague-Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p 
Dyary, Hiewa O., Abd. Kadir, Arifah, Sharma, Reuben Sunil Kumar, Abdullah, Rasedee, Md. Sukari, Mohd Aspollah, Zakaria, Zainul Amiruddin, Ahmad, Zuraini, Somchit, Muhammad Nazrul   +7 more
openaire   +2 more sources

Using deep learning to assess the toxicological effects of sublethal exposure of a novel green pesticide in a stored‐product beetle

Pest Management Science, Volume 82, Issue 5, Page 4319-4331, May 2026.
This study employs an AI‐driven multidisciplinary approach to increase our understanding of the toxicological effects of sublethal concentrations of carlina oxide on Prostephanus truncatus. Sublethal exposure to the carlina oxide induced changes in motor patterns and thigmotaxis, highlighting its potential role in integrated pest management strategies.
Anita Casadei, Maria C. Boukouvala, Gianluca Manduca, Nickolas G. Kavallieratos, Filippo Maggi, Marta Ferrati, Eleonora Spinozzi, Cesare Stefanini, Antonio DeSimone, Donato Romano   +9 more
wiley   +1 more source

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium

Pathogens, 2021
Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and
Ahmed M. Zheoat, Samya Alenezi, Ehab Kotb Elmahallawy, Marzuq A. Ungogo, Ali H. Alghamdi, David G. Watson, John O. Igoli, Alexander I. Gray, Harry P. de Koning, Valerie A. Ferro   +9 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

In vivo Trypanostatic Activity of Tephrosia linearis Extract on Trypanosoma evansi

Fountain Journal of Natural and Applied Sciences (FUJNAS), 2021
In vivo antitrypanosomal activity of 70% methanol extract of Tephrosia linearis was evaluated. Mice infected with Trypanosoma evansi in different groups were administered 100, 200, 300 and 400 mg/kg body weight/day of the seventy percent (v/v) (methanol/
M. H. Garba, T. O. Ampitan, R. A. AbdulAzeez, A-A. Tawakaltu, E. A. Fajobi, C. A. Jeje   +5 more
doaj   +1 more source

Synthesis of 1H-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole and Evaluation of Its Antiprotozoal Activity

Molbank, 2019
1H-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole was synthesized via a multi-step pathway starting from 2-iodoaniline. Structure characterization of this new indole compound was achieved by 1H-NMR, 13C-NMR and ESI-MS spectral analysis ...
Jean Guillon, Clotilde Boudot, Anita Cohen, Solène Savrimoutou, Sandra Rubio, Vittoria Milano, Mathieu Marchivie, Nadine Azas, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +10 more
doaj   +1 more source

Metabolomics and Dereplication Study of the Endophytic Fungus Aspergillus chevelieri in Search of Bioactive Natural Compounds [PDF]

Journal of Advanced Pharmacy Research, 2017
Objectives: This study aimed to point the significant rule of metabolomics tools to assess the chemistry of the bioactive metabolites produced by endophytic fungus Aspergillus chevelieri isolated from Lagerostromia tomentosa C. presl.
Nashwa Tawfik, ِAhmed Tawfike, Randa Abdo, Grainne Abbott, Usama Abdelmohsen, RuAngelie Edrada-Ebel, Eman Haggag   +6 more
doaj   +1 more source