Results 81 to 90 of about 2,263 (168)

Evaluation of the Antitrypanosomal Activity of the Crude Extracts of Uvaria Ovata: In vitro and In silico Approach

Biomedical and Biotechnology Research Journal
Background: Human African trypanosomiasis is the third disease with most mortalities among the neglected tropical diseases. The absence of vaccines and the development of parasite resistance have necessitated the quest for new affordable and safe ...
Mary Anti Chama, Beverly Egyir, Kofi Baffour-Awuah Owusu, Jessica Asomaniwaa Armah, Michael Afiadenyo, Samuel Kojo Kwofie   +5 more
doaj   +1 more source

Natural Sesquiterpene Lactones of the 4,15-iso-Atriplicolide Type are Inhibitors of Trypanothione Reductase

Molecules, 2019
In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15-iso-Atriplicolide tiglate, which demonstrated an IC50 value of 15 nM against ...
Mairin Lenz, R. Luise Krauth-Siegel, Thomas J. Schmidt   +2 more
doaj   +1 more source

Integrated In Vitro and In Silico Profiling of Piperazinyl Thiosemicarbazone Derivatives Against Trypanosoma cruzi: Stage-Specific Activity and Enzyme Inhibition

Pharmaceuticals
Background: Trypanosoma cruzi, the causative agent of Chagas disease, remains a major public health concern, and there is a continued need for new antitrypanosomal agents. Thiosemicarbazone (TSC) derivatives have emerged as a promising class of compounds
Héctor A. Baldoni, María L. Sbaraglini, Darío E. Balcazar, Diego G. Arias, Sergio A. Guerrero, Catalina D. Alba Soto, Wioleta Cieslik, Marta Rogalska, Jaroslaw Polański, Ricardo D. Enriz, Josef Jampilek, Robert Musiol   +11 more
doaj   +1 more source

Antitrypanosomal Activity of Brazilian Propolis from Apis mellifera

Chemical and Pharmaceutical Bulletin, 2004
Extracts from different samples of Brazilian propolis were obtained by Soxhlet extraction or maceration at room temperature using ethanol, water, and accombination of both solvents. Analysis of their composition using HPLC revealed that no major differences were seen when a propolis sample was subject to different extraction methods.
Silva Cunha, Ildenize Barbosa da, Salomão, Kelly, Shimizu, Mario, Bankova, Vassya S., Custódio, Angela Ramalho, Castro, Solange Lisboa de, Marcucci, Maria Cristina   +6 more
openaire   +3 more sources

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models. [PDF]

Biology (Basel), 2023
Orlando LMR, Lara LDS, Lechuga GC, Rodrigues GC, Pandoli OG, de Sá DS, Pereira MCS.   +6 more
europepmc   +1 more source

Antitrypanosomal activity of Tithonia Diversifolia

, 2016
The African Trypanosomiases, also commonly called African sleeping sickness in humans (HAT) and “Nagana” in domestic livestock, are fatal neglected diseases that occur in 36 sub-Saharan African countries. The disease progresses through two stages and is caused by two subspecies of the parasite T. brucei: T. b. gambiense (West Africa; Tbg) and T.
Dall’Acqua, Stefano, Sut, Stefania, Baldan, Valeria, PETRELLI, Riccardo, Ranjbarian, Farah, Hofer, Anders, CAPPELLACCI, Loredana, MAGGI, Filippo   +7 more
openaire   +1 more source

Antimicrobial and antitrypanosomal activities of methanol root extract and fractions of Brenania brieyi (De Wild) Petit (Rubiaceae)

African Journal of Pharmaceutical Research and Development (AJOPRED)
Brenania brieyi (Rubiaceae) is used in ethnomedicine for the treatment of malaria, microbial infections, trypanosomal disease, infertility and inflammatory disorders.
Ifeyinwa Chioma Ezeala, Philip Felix Uzor, Charity Ukamaka Obiora, Chidimma Maryann Enendu, Chidozie Innocent Anyadiegwu, Ngozi Justina Nwodo   +5 more
doaj  

Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents. [PDF]

Antibiotics (Basel), 2021
Baldassarri C, Falappa G, Mazzara E, Acquaticci L, Ossoli E, Perinelli DR, Bonacucina G, Dall'Acqua S, Cappellacci L, Maggi F, Ranjbarian F, Hofer A, Petrelli R.   +12 more
europepmc   +1 more source

Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines. [PDF]

Heliyon, 2021
Espinosa R, Robledo S, Guzmán C, Arbeláez N, Yepes L, Santafé G, Sáez A.   +6 more
europepmc   +1 more source

Antitrypanosomal activity of hydromethanol extract of leaves of Cymbopogon citratus and seeds of Lepidium sativum: in-vivo mice model. [PDF]

BMC Complement Med Ther, 2021
Emiru AY, Makonnen E, Regassa F, Regassa F, Tufa TB.   +4 more
europepmc   +1 more source