Results 71 to 80 of about 2,263 (168)

Diminazene Aceturate Ameliorates Hypertension‐Induced Cognitive Impairment by Disrupting the CCN1–Integrin αvβ6–TGF‐β Axis and Preserving Mitochondrial Integrity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Hypertension drives cognitive decline through a previously unrecognized CCN1–integrin αvβ6–TGF‐β signaling axis that culminates in mitochondrial dysfunction and hippocampal neuronal injury. In this pathway, angiotensin II induces CCN1 upregulation, which activates αvβ6 integrin‐mediated release of latent TGF‐β, triggering SMAD2/3 phosphorylation and ...
Xufang Huo, Zhenyu Wu, Xinqian Zhou, Yuancheng Zhou, Jiming Liu, Hongbing Li, Yijiu Wu, You Huang, Guangling Feng, Xiaolin Hu, Qingfan Zeng   +10 more
wiley   +1 more source

Amides from Porcelia ponderosa Roots Display Efficacy In Vitro Against Intracellular Amastigotes of Trypanosoma cruzi

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Amides from Porcelia ponderosa display potent activity against amastigotes from Trypanosoma cruzi. ABSTRACT In the present work, the MeOH extract from roots of Porcelia ponderosa R.E. Fries (Annonaceae) was subjected to several chromatographic techniques to afford three chemically related amides: N‐trans‐p‐coumaroyltyramine (1), N‐trans ...
Carlos Henrique T. Dos Santos, Mariana B. Abiuzi, Beatriz A. De Andrade, Erica V. C. Levatti, Mariana H. Chaves, Andre G. Tempone, João Henrique G. Lago   +6 more
wiley   +1 more source

Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms

Frontiers in Microbiology, 2019
AimsChemical and biological studies of the River Nile derived-microorganisms are limited. Hence, this work was carried out to screen the River Nile habitat.
Momen M. Lotfy, Hossam M. Hassan, Hossam M. Hassan, Rabab Mohammed, Mona Hetta, Ahmed O. El-Gendy, Mostafa E. Rateb, Mostafa E. Rateb, Mohamed A. Zaki, Noha M. Gamaleldin, Noha M. Gamaleldin   +10 more
doaj   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities

Natural Products and Bioprospecting, 2020
In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (
Mohammad Sanad Abu-Darwish, Célia Cabral, Zulfigar Ali, Mei Wang, Shabana I. Khan, Melissa R. Jacob, Surendra K. Jain, Babu L. Tekwani, Fazila Zulfiqar, Ikhlas A. Khan, Hatem Taifour, Lígia Salgueiro, Thomas Efferth   +12 more
doaj   +1 more source

Evaluating the influence of trypanosomiasis on murine model using Corchorus olitorius leaf extract as a trypanocidal agent [PDF]

Bulletin of Natural Sciences Research
Trypanosomiasis, a parasitic disease caused by trypanosomes, which are flagellate protozoa transmitted through the bite of the tsetse fly, manifests with symptoms including substantial weight loss, anemia, fever, edema, adenitis, dermatitis, and nervous ...
Madaki Fatima M., Adamu Kabiru Y., Ogunrombi Clinton D., Sakariyau Waheed A., Yunusa Ibrahim O.   +4 more
doaj   +1 more source

Ethnomedicinal Evidence for Medicinal Plants of the Asteraceae Family Used by Tanzanians to Treat Various Ailments: A Review

BioMed Research International, Volume 2026, Issue 1, 2026.
The Asteraceae family is amongst the most important groups of flowering plants, widely recognised for its ethnomedicinal relevance. This systematic review, conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, synthesises evidence on the traditional medicinal uses of Asteraceae species in ...
David Sylvester Kacholi, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Quinoxaline 1, 4-di-N-oxides: Biological activities and mechanisms of actions

Frontiers in Pharmacology, 2016
Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities.
Guyue eCheng, Wei eSa, Chen eCao, Liangliang eGuo, Haihong eHao, Zhenli eLiu, Xu eWang, Zonghui eYuan   +7 more
doaj   +1 more source

Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei

International Journal for Parasitology: Drugs and Drug Resistance
Trypanosomiasis is a parasitic disease for which new treatments are needed due to the frequent occurrence of adverse side effects of current available drugs.
Lúcia Mamede, Fanta Fall, Madeline Vast, Kristelle Hughes, Giorgia Martelli, Francesco Caligiore, Bernadette Govaerts, Paul A.M. Michels, Michel Frédérich, Joëlle Quetin-Leclercq   +9 more
doaj   +1 more source