Results 141 to 150 of about 2,581 (172)

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

Medicinal Chemistry, 2020
Background: Approximately, 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die of complications linked to this disease. Method: This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol ...
Natália N. Santiago, Giulianna P. de Alcântara, Juliana S. da Costa, Samir A. Carvalho, Juliana M.C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M.G. Pereira, Edson F. da Silva   +8 more
openaire   +2 more sources

Prolylisoxazoles: Potent Inhibitors of Prolyloligopeptidase with Antitrypanosomal Activity.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Bal, Gunther, van Der Veken, Pieter, Antonov, Dimitri, Lambeir, Anne-Marie, Grellier, Philippe, Croft, Simon, Augustyns, Koen, Haemers, Achiel   +7 more
openaire   +4 more sources

Effect of verapamil on antitrypanosomal activity of drugs in mice

Acta Tropica, 1993
The effects of verapamil on drug responses of Trypanosoma brucei brucei were studied to determine whether drug resistance of this organism could be related to expression of a drug resistance gene as has been described for drug-resistant cancer cells and malaria.
S A, Agbe, K L, Yielding
openaire   +2 more sources

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Bioorganic & Medicinal Chemistry Letters, 2006
A series of polyaminoguanidines and polyaminobiguanides were synthesized and evaluated as potential antitrypanosomal agents. These analogues inhibit trypanothione reductase (TR) with IC50 values as low as 0.95 microM, but do not inhibit the closely related human enzyme glutathione reductase (GR).
Xiangdong, Bi, Christina, Lopez, Cyrus J, Bacchi, Donna, Rattendi, Patrick M, Woster   +4 more
openaire   +2 more sources

Antitrypanosomal isoflavan quinones from Abrus precatorius

Fitoterapia, 2014
Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices.
Hata, Yoshie, Ebrahimi, Samad Nejad, De Mieri, Maria, Zimmermann, Stefanie, Mokoka, Tsholofelo, Naidoo, Dashnie, Fouche, Gerda, Maharaj, Vinesh, Kaiser, Marcel, Brun, Reto, Potterat, Olivier, Hamburger, Matthias   +11 more
openaire   +4 more sources

Antitrypanosomal Action of Cis-Diamminedichloroplatinum (II) Analogs

The Journal of Parasitology, 1987
The present report deals with the alterations produced by cis-diamminedichloroplatinum (II) (DDP), and 2 of its analogs: cis-Pt(II)(tranylcypromine)2Cl2 and cis-Pt(II)(benzothiazole)2Cl2 in cultured epimastigote forms of Trypanosoma cruzi. Studies have been performed at the ultrastructural level and the inhibitory effect of these complexes on ...
A, Osuna, L M, Ruiz-Perez, M C, Lopez, S, Castanys, F, Gamarro, D G, Craciunescu, C, Alonso   +6 more
openaire   +2 more sources

Antileishmanial and Antitrypanosomal Activities of Flavonoids

2018
This chapter focuses on the ability of flavonoid aglycones and glycosides to inhibit the growth of protozoan parasites of the genera Leishmania and Trypanosoma in different in vitro and in vivo models, namely pathogenic species for humans implicated in visceral (L. donovani, L. infantum) and cutaneous leishmaniasis (L. braziliensis, L.
Flore Nardella, Jean-Baptiste Gallé, Mélanie Bourjot, Bernard Weniger, Catherine Vonthron-Sénécheau   +4 more
openaire   +1 more source

The Effect of Cysteine on the Antitrypanosome Activity of Antimonials

Journal of Infectious Diseases, 1948
G, CHEN, E M K, GEILING
openaire   +2 more sources

The Determination of Antitrypanosome Effect of Antimonials In Vitro

Journal of Infectious Diseases, 1945
G, CHEN, E M K, GEILING
openaire   +2 more sources

Antitrypanosomal Drugs

2006
openaire   +2 more sources