Results 101 to 110 of about 50,974 (272)

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

ACS Infectious Diseases, 2019
MmpL3, an essential transporter involved in the export of mycolic acids, is the proposed target of a number of antimycobacterial inhibitors under development.
Wei Li, Casey M Stevens, Amit N. Pandya, Z. Darżynkiewicz, Pankaj Bhattarai, Weiwei Tong, M. Gonzalez-Juarrero, E. J. North, H. Zgurskaya, M. Jackson   +9 more
semanticscholar   +1 more source

Ligand-based discovery of novel N-arylpyrrole derivatives as broad-spectrum antimicrobial agents with antibiofilm and anti-virulence activity

Journal of Enzyme Inhibition and Medicinal Chemistry
The escalating threat of antimicrobial resistance calls for novel therapeutic agents. This study employed a ligand-based design approach to develop three series of N-arylpyrrole derivatives (Va–e, VIa–e, and VIIa–e), refined through molecular modeling ...
Basma M. Qandeel, Samar Mowafy, Mohamed F. El-Badawy, Nahla A. Farag, Galal Yahya, Khaled Abouzid   +5 more
doaj   +1 more source

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. [PDF]

, 2015
In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4 ...
Cabrera, JL, Caviedes, L, Chavez, G, Evans, CA, Friedland, JS, Gilman, RH, Kirwan, DE, Lymph Node TB Working Group, Peru, Matos, ED, Moore, DAJ, Rizvi, H, Ticona, E, Ugarte-Gil, C   +12 more
core   +3 more sources

Pyrimidine derivatives with antitubercular activity.

European journal of medicinal chemistry, 2022
Vladimir Finger, M. Kufa, O. Soukup, D. Castagnolo, Jaroslav Roh, J. Korábečný   +5 more
semanticscholar   +1 more source

Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts

Journal of Enzyme Inhibition and Medicinal Chemistry
Despite efforts to discover effective treatments to eradicate tuberculosis (TB), it remains a global threat. The increase in drug-resistant bacterial species has made the discovery of new drugs highly coveted.
Yucheng Lu, Daniel Partleton, Filibus M. Gugu, Ahmed Y. G. Alhejaili, Samuel Norris, J. Jonathan Harburn, Jason H. Gill, Jonathan D. Sellars, Alistair K. Brown   +8 more
doaj   +1 more source

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]

, 2009
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu, Beatrice Bechi, Biava, Biava, Biava, Brock, Castagnolo, Daniele Castagnolo, De Logu, Deidda, Fabrizio Manetti, Gutierrez-Lugo, Holzer, Janin, Mafalda Pagano, Manetti, Manuela Saddi, Marco Radi, Maurizio Botta, Rita Meleddu   +19 more
core   +1 more source

Synthesis, in-vitro antitubercular, antifungal activities and in silico molecular docking study of Chalcone derivatives from 1-(2'-Hydroxyphenyl)-3-(substituted-phenyl)-2-propenone.

, 2023
Arnold Mulula, Abdeldjalil Bouzina, Hugues Mambu, Gracia Mbiye, Ahmed Zaki   +4 more
openalex   +1 more source

Histomorphological features of combined forms of tuberculosis and lung cancer [PDF]

Medičnì Perspektivi, 2017
The were studied pathological features of combined forms of tuberculosis and non-small cell lung cancer in 72 patients who underwent radical surgical resection interventions from transsternal access with mediastinal lymph node dissection, with ...
Savenkov Y.F., Koshak Y.F., Malcev I.A., Korpusenko I.V., Bakulin P.E.   +4 more
doaj  

Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2016
Most of the introduced susceptibility methods of Mycobacterium tuberculosis have some disadvantages for screening. Therefore, the selection of susceptibility assay for evaluating candidate agents must be determined case by case.
Mehdi Zandhaghighi, Kiarash Ghazvini, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Saman Soleimanpour, Farzin Hadizadeh   +6 more
doaj   +1 more source

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]

, 2019
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde, Yi, Chae S.   +1 more
core   +3 more sources