Results 1 to 10 of about 531,165 (296)

Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity.

Cell Metabolism, 2023
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to defective antitumor responses.
Carina B. Nava Lauson, S. Tiberti, P. Corsetto, F. Conte, Punit Tyagi, M. Machwirth, S. Ebert, A. Loffreda, L. Scheller, D. Sheta, Zeinab Mokhtari, Timo Peters, Ayush T. Raman, F. Greco, A. Rizzo, A. Beilhack, Giovanni Signore, N. Tumino, P. Vacca, L. McDonnell, A. Raimondi, P. Greenberg, J. Huppa, S. Cardaci, Ignazio Caruana, S. Rodighiero, L. Nezi, T. Manzo   +27 more
semanticscholar   +1 more source

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability.

Cell Metabolism, 2021
Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8+ T cells, which was induced by TME ...
Xingzhe Ma, Liuling Xiao, Lintao Liu, Lingqun Ye, Pan Su, Enguang Bi, Qiang Wang, Maojie Yang, J. Qian, Q. Yi   +9 more
semanticscholar   +1 more source

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity.

Cell Reports, 2021
T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor immunity, but the mechanisms governing their cellular redox homeostasis remain elusive. We report that glutathione peroxidase 4 (Gpx4) prevents Treg cells from lipid
Chengxian Xu, Shaogang Sun, T. Johnson, Rong Qi, Siyuan Zhang, Jie Zhang, Kai Yang   +6 more
semanticscholar   +1 more source

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

Frontiers in Pharmacology, 2022
Hyperactivation of Bruton’s tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton’s tyrosine kinase and interleukin-2 ...
Peiran Song, Peiran Song, Gang Bai, Shingpan Chan, Tao Zhang, Linjiang Tong, Yi Su, Yanyan Shen, Yi Chen, Yingqiang Liu, Mengzhen Lai, Mengzhen Lai, Yi Ning, Haotian Tang, Yan Fang, Yi Chen, Ke Ding, Jian Ding, Jian Ding, Hua Xie, Hua Xie, Hua Xie   +21 more
doaj   +1 more source

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Molecular Cancer, 2020
Background Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven by the EGFR T790M mutation.
Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie   +20 more
doaj   +1 more source

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3

Cell Death and Disease, 2023
CMTR1, also called IFN-stimulated gene 95 kDa protein (ISG95), is elevated by viral infection in a variety of cells. However, the functions of CMTR1 in colorectal cancer (CRC), especially its roles in tumorigenesis and immune regulation, remain unclear ...
A-bin You, Hu Yang, Chun-ping Lai, Wen Lei, Lu Yang, Jia-lin Lin, Shun-cui Liu, Nan Ding, Feng Ye   +8 more
doaj   +1 more source

A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress

Molecules, 2023
Oxidative stress is caused by an imbalance between reactive oxygen species and antioxidant levels. Current research suggests that oxidative stress is one of the key factors in the development of many chronic diseases, and it has been a concern for many ...
Chong Hong, Xu Wang, Jianjian Xu, Jianxing Guo, Houlin Peng, Yan Zhang   +5 more
doaj   +1 more source

Genomic profiling of WRKY transcription factors and functional analysis of CcWRKY7, CcWRKY29, and CcWRKY32 related to protoberberine alkaloids biosynthesis in Coptis chinensis Franch

Frontiers in Genetics, 2023
Coptis chinensis Franch. (Huanglian in Chinese) is an important economic crop with medicinal value. Its rhizome has been used as a traditional herbal medicine for thousands of years in Asia.
Xiaoqiang Huang, An Jia, Tao Huang, Li Wang, Guohua Yang, Wanli Zhao, Wanli Zhao   +6 more
doaj   +1 more source

Reprogramming antitumor immunity [PDF]

Trends in Immunology, 2014
Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context,
Joseph G, Crompton, David, Clever, Raul, Vizcardo, Mahendra, Rao, Nicholas P, Restifo   +4 more
openaire   +2 more sources

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Cancer Discovery, 2022
Therapy-induced senescence renders cancer cells highly immunogenic, making them very efficient in triggering protective CD8-dependent antitumor immune responses.
I. Marín, Olga Boix, Andrea García-Garijo, I. Sirois, Adrià Caballé, E. Zarzuela, Irene Ruano, C. Stephan-Otto Attolini, N. Prats, J. López-Domínguez, Marta Kovatcheva, E. Garralda, Javier Muñoz, E. Caron, M. Abad, A. Gros, F. Pietrocola, M. Serrano   +17 more
semanticscholar   +1 more source