Results 1 to 10 of about 506,874 (259)
Diarylureas as Antitumor Agents [PDF]
Applied Sciences, 2021 The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti-inflammatory properties. Some diarylureas, serine-threonine kinase or tyrosine kinase inhibitors, were recently reported in literature.
Catalano, Alessia +3 more
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Antitumor Effects of Selenium [PDF]
International Journal of Molecular Sciences, 2021 Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites.
Seung Jo Kim +3 more
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Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways. [PDF]
, 2014 Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers.
Deng, Wuguo +10 more
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Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions [PDF]
, 2010 The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce ...
Gong, Jianlin +10 more
core +11 more sources
Flaviviruses in AntiTumor Therapy
Viruses, 2023 Oncolytic viruses offer a promising approach to tumor treatment. These viruses not only have a direct lytic effect on tumor cells but can also modify the tumor microenvironment and activate antitumor immunity. Due to their high pathogenicity, flaviviruses have often been overlooked as potential antitumor agents.
Alina S. Nazarenko +7 more
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, 2011 Ribonucleases are small basic proteins that have shown remarkable antitumor activity linked to their ability to destroy RNA. Therefore, they are a second line of cancer chemotherapeutics as they are not genotoxic. This chapter summarizes the main biochemical characteristics of these enzymes and the key factors responsible for their cytotoxic mechanism.
Ribó i Panosa, Marc +2 more
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Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics [PDF]
Japanese Journal of Cancer Research, 1992 The anticellular and antitumor activities of novel antitumor antibiotics, duocarmycins (DUMs), were examined against human and murine tumor cells. DUMs consist of live compounds, A, B1, B2, C1, and C2, which possess a pharmacophore similar to that of CC‐1065, a previously isolated antibiotic.
Akihiko Okamoto +9 more
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Antitumor Drugs and Their Targets [PDF]
Molecules, 2020 Through novel methodologies, including both basic and clinical research, progress has been made in the therapy of solid cancer. Recent innovations in anticancer therapies, including immune checkpoint inhibitor biologics, therapeutic vaccines, small drugs, and CAR-T cell injections, mark a new epoch in cancer research, already known for faster (epi ...
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Antitumor factors of draining lymph node cells of the mouse sensitized with ehrlich ascites tumor cells. I. Antitumor effect of subcellular factor [PDF]
, 1969 The regional lymph node cells of the mice sensitized with Ehrlich ascites tumor cells is known to possess a substance that shows antitumor activity on target cells (JTC-II cells). For the purpose to clarify the localization of this substance the regional
Nakashima, Youichi
core +1 more source
Improvement of antitumor therapies based on vaccines and immune-checkpoint inhibitors by counteracting tumor-immunostimulationw [PDF]
, 2018 Immune-checkpoint inhibitors and antitumor vaccines may produce both tumor-inhibitory and tumor-stimulatory effects on growing tumors depending on the stage of tumor growth at which treatment is initiated.
Bustuoabad, Oscar David +8 more
core +2 more sources