Results 1 to 10 of about 840,802 (388)

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +16 more sources

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

Frontiers in Pharmacology, 2022
Hyperactivation of Bruton’s tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton’s tyrosine kinase and interleukin-2 ...
Peiran Song, Peiran Song, Gang Bai, Shingpan Chan, Tao Zhang, Linjiang Tong, Yi Su, Yanyan Shen, Yi Chen, Yingqiang Liu, Mengzhen Lai, Mengzhen Lai, Yi Ning, Haotian Tang, Yan Fang, Yi Chen, Ke Ding, Jian Ding, Jian Ding, Hua Xie, Hua Xie, Hua Xie   +21 more
doaj   +1 more source

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Molecular Cancer, 2020
Background Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven by the EGFR T790M mutation.
Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie   +20 more
doaj   +1 more source

CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3

Cell Death and Disease, 2023
CMTR1, also called IFN-stimulated gene 95 kDa protein (ISG95), is elevated by viral infection in a variety of cells. However, the functions of CMTR1 in colorectal cancer (CRC), especially its roles in tumorigenesis and immune regulation, remain unclear ...
A-bin You, Hu Yang, Chun-ping Lai, Wen Lei, Lu Yang, Jia-lin Lin, Shun-cui Liu, Nan Ding, Feng Ye   +8 more
doaj   +1 more source

Genomic profiling of WRKY transcription factors and functional analysis of CcWRKY7, CcWRKY29, and CcWRKY32 related to protoberberine alkaloids biosynthesis in Coptis chinensis Franch

Frontiers in Genetics, 2023
Coptis chinensis Franch. (Huanglian in Chinese) is an important economic crop with medicinal value. Its rhizome has been used as a traditional herbal medicine for thousands of years in Asia.
Xiaoqiang Huang, An Jia, Tao Huang, Li Wang, Guohua Yang, Wanli Zhao, Wanli Zhao   +6 more
doaj   +1 more source

A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress

Molecules, 2023
Oxidative stress is caused by an imbalance between reactive oxygen species and antioxidant levels. Current research suggests that oxidative stress is one of the key factors in the development of many chronic diseases, and it has been a concern for many ...
Chong Hong, Xu Wang, Jianjian Xu, Jianxing Guo, Houlin Peng, Yan Zhang   +5 more
doaj   +1 more source

Reprogramming antitumor immunity [PDF]

Trends in Immunology, 2014
Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context,
Joseph G, Crompton, David, Clever, Raul, Vizcardo, Mahendra, Rao, Nicholas P, Restifo   +4 more
openaire   +2 more sources

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

Frontiers in Oncology, 2018
Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs.
Marissa Mattar, Craig R. McCarthy, Amanda R. Kulick, Besnik Qeriqi, Sean Guzman, Elisa de Stanchina   +5 more
doaj   +1 more source

Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway

Acta Biochimica et Biophysica Sinica, 2022
Primary hepatic carcinoma is a common malignant tumor. The classic molecular targeted drug sorafenib is costly and is only effective for some patients.
Zhang Yonghui, Zhang Haoyang, Mu Jinage, Han Meiyue, Cao Zhihao, Dong Feng, Wang Tingting, Pan Lian, Luo Wujing, Li Jiaxin, Liu Huan, Jin Lishan, Ding Wenxuan, Wei Yong, Deng Xuesong, Liu Dan, He Xiuzhen, Pang Yi, Mu Xiao, Wu Zhongjun, Chen Dilong   +20 more
doaj   +1 more source

The Pharmacological Potential of Mushrooms [PDF]

, 2005
This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor, antiallergic, immunomodulating, anti-inflammatory, antiatherogenic, hypoglycemic, hepatoprotective and ...
Jülich, Wolf-Dieter, Lindequist, Ulrike, Niedermeyer, Timo H. J.   +2 more
core   +3 more sources