Results 11 to 20 of about 840,802 (388)

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Cancer Discovery, 2022
Therapy-induced senescence renders cancer cells highly immunogenic, making them very efficient in triggering protective CD8-dependent antitumor immune responses.
I. Marín, Olga Boix, Andrea García-Garijo, I. Sirois, Adrià Caballé, E. Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, J. López-Domínguez, M. Kovatcheva, E. Garralda, Javier Muñoz, E. Caron, M. Abad, A. Gros, F. Pietrocola, M. Serrano   +17 more
semanticscholar   +1 more source

Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy

Theranostics, 2020
Magnetic hyperthermia (MH) has been introduced clinically as an alternative approach for the focal treatment of tumors. MH utilizes the heat generated by the magnetic nanoparticles (MNPs) when subjected to an alternating magnetic field (AMF).
Xiaoli Liu, Yifan Zhang, Yanyun Wang, W. Zhu, Galong Li, Xiaowei Ma, Yihan Zhang, Shizhu Chen, Shivani Tiwari, Kejian Shi, Shouwen Zhang, H. Fan, Yong Xiang Zhao, Xing-jie Liang   +13 more
semanticscholar   +1 more source

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Cancer Discovery, 2022
The polyphenol castalagin acts as a prebiotic and exerts antitumor activity as well as potentiates anti–PD-1 immune efficacy through a beneficial shift in microbiome composition.
M. Messaoudene, Reilly Pidgeon, C. Richard, M. Ponce, K. Diop, Myriam Benlaifaoui, Alexis Nolin-Lapalme, F. Cauchois, J. Malo, W. Belkaid, S. Isnard, Y. Fradet, Lharbi Dridi, D. Velin, P. Oster, D. Raoult, F. Ghiringhelli, R. Boidot, Sandy Chevrier, David T. Kysela, Y. Brun, E. Falcone, G. Pilon, Florian Plaza Oñate, Oscar Gitton-Quent, E. Le Chatelier, Sylvère Durand, G. Kroemer, A. Elkrief, A. Marette, Bastien Castagner, B. Routy   +31 more
semanticscholar   +1 more source

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Journal for ImmunoTherapy of Cancer, 2020
Background Immunotherapy represents the future of clinical cancer treatment. The type of cancer cell death determines the antitumor immune response and thereby contributes to the efficacy of anticancer therapy and long-term survival of patients ...
Iuliia Efimova, E. Catanzaro, Louis Van der Meeren, Victoria D. Turubanova, H. Hammad, T. Mishchenko, M. Vedunova, C. Fimognari, C. Bachert, F. Coppieters, Steve Lefever, A. Skirtach, O. Krysko, D. Krysko   +13 more
semanticscholar   +1 more source

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

Science immunology, 2020
PD-1 ablation regulates metabolism-driven lineage fate commitment of myeloid progenitors and differentiation of effector myeloid cells (see the related Focus by Rudd). A twist in the PD-1 tale Immunotherapies targeting programmed cell death protein 1 (PD-
L. Strauss, Mohamed A. Mahmoud, J. Weaver, Natalia M. Tijaro-Ovalle, A. Christofides, Qi Wang, R. Pal, Min Yuan, J. Asara, N. Patsoukis, V. Boussiotis   +10 more
semanticscholar   +1 more source

Influence of Long-term Cytotoxic Chemotherapy on the Condition of Peripheral Venous Channel [PDF]

, 2017
The necessity of long-term venous access in cancer patients appears at frequent and long-term courses of cytotoxic therapy. Peripheral veins of forearms are most often used for these aims. The conditions of peripheral venous channel in 32 cancer patients,
Tkachuk, T. (Tetiana)
core   +2 more sources

Gilvocarcins,new antitumor antibiotics 3. Antitumor activity.

The Journal of Antibiotics, 1981
Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. In particular, 40% of treated mice survived for 60 days, after intraperitoneal administration of gilvocarcin V to mice bearing Ehrlich ascites ...
M, Morimoto, S, Okubo, F, Tomita, H, Marumo   +3 more
openaire   +3 more sources

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Frontiers in Immunology, 2020
The success of cancer immunotherapy relies on the knowledge of the tumor microenvironment and the immune evasion mechanisms in which the tumor, stroma, and infiltrating immune cells function in a complex network.
A. Labani-Motlagh, Mehrnoush Ashja-Mahdavi, A. Loskog   +2 more
semanticscholar   +1 more source

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Signal Transduction and Targeted Therapy, 2023
Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met inhibitors (c-Metis), yet the overall ...
Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, Yi-Long Wu, Meiyu Geng, Jing Ai   +18 more
doaj   +1 more source

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Acta Pharmaceutica Sinica B, 2023
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults and is poorly controlled. Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression, and co-targeting of CSF1R and ...
Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang, Mengyuan Li, Yongcong Lv, Shenglan Li, Linjiang Tong, Fang Feng, Yan Li, Mengge Zhang, Yaping Xue, Yi Chen, Tao Zhang, Peiran Song, Yi Su, Yanyan Shen, Yiming Sun, Xinying Yang, Yi Chen, Shanyan Yao, Hanyu Yang, Caixia Wang, Meiyu Geng, Wenbin Li, Wenhu Duan, Hua Xie, Jian Ding   +26 more
doaj   +1 more source