Results 11 to 20 of about 531,165 (296)

Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy

Theranostics, 2020
Magnetic hyperthermia (MH) has been introduced clinically as an alternative approach for the focal treatment of tumors. MH utilizes the heat generated by the magnetic nanoparticles (MNPs) when subjected to an alternating magnetic field (AMF).
Xiaoli Liu, Yifan Zhang, Yanyun Wang, W. Zhu, Galong Li, Xiaowei Ma, Yihan Zhang, Shizhu Chen, Shivani Tiwari, Kejian Shi, Shouwen Zhang, H. Fan, Yong-xiang Zhao, Xing-jie Liang   +13 more
semanticscholar   +1 more source

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

Frontiers in Oncology, 2018
Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs.
Marissa Mattar, Craig R. McCarthy, Amanda R. Kulick, Besnik Qeriqi, Sean Guzman, Elisa de Stanchina   +5 more
doaj   +1 more source

Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway

Acta Biochimica et Biophysica Sinica, 2022
Primary hepatic carcinoma is a common malignant tumor. The classic molecular targeted drug sorafenib is costly and is only effective for some patients.
Zhang Yonghui, Zhang Haoyang, Mu Jinage, Han Meiyue, Cao Zhihao, Dong Feng, Wang Tingting, Pan Lian, Luo Wujing, Li Jiaxin, Liu Huan, Jin Lishan, Ding Wenxuan, Wei Yong, Deng Xuesong, Liu Dan, He Xiuzhen, Pang Yi, Mu Xiao, Wu Zhongjun, Chen Dilong   +20 more
doaj   +1 more source

Gilvocarcins,new antitumor antibiotics 3. Antitumor activity.

The Journal of Antibiotics, 1981
Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. In particular, 40% of treated mice survived for 60 days, after intraperitoneal administration of gilvocarcin V to mice bearing Ehrlich ascites ...
M, Morimoto, S, Okubo, F, Tomita, H, Marumo   +3 more
openaire   +3 more sources

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Cancer Discovery, 2022
The polyphenol castalagin acts as a prebiotic and exerts antitumor activity as well as potentiates anti–PD-1 immune efficacy through a beneficial shift in microbiome composition.
M. Messaoudene, Reilly Pidgeon, C. Richard, M. Ponce, K. Diop, Myriam Benlaifaoui, Alexis Nolin-Lapalme, F. Cauchois, J. Malo, W. Belkaid, S. Isnard, Y. Fradet, Lharbi Dridi, D. Velin, P. Oster, D. Raoult, F. Ghiringhelli, R. Boidot, Sandy Chevrier, David T. Kysela, Y. Brun, E. Falcone, G. Pilon, Florian Plaza Oñate, Oscar Gitton-Quent, E. Le Chatelier, S. Durand, G. Kroemer, A. Elkrief, A. Marette, Bastien Castagner, B. Routy   +31 more
semanticscholar   +1 more source

Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis

Biology Direct, 2021
Background Recently, overwhelming evidence supports that long noncoding RNAs (lncRNAs) play crucial roles in the occurrence and progression of tumors. However, the role and mechanism of lncRNA TFAP2A-AS1 in human gastric cancer (GC) remains unclear. Thus,
Xin Zhao, Linlin Chen, Jingxun Wu, Jun You, Qingqi Hong, Feng Ye   +5 more
doaj   +1 more source

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Acta Pharmaceutica Sinica B, 2023
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults and is poorly controlled. Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression, and co-targeting of CSF1R and ...
Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang, Mengyuan Li, Yongcong Lv, Shenglan Li, Linjiang Tong, Fang Feng, Yan Li, Mengge Zhang, Yaping Xue, Yi Chen, Tao Zhang, Peiran Song, Yi Su, Yanyan Shen, Yiming Sun, Xinying Yang, Yi Chen, Shanyan Yao, Hanyu Yang, Caixia Wang, Meiyu Geng, Wenbin Li, Wenhu Duan, Hua Xie, Jian Ding   +26 more
doaj   +1 more source

Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics [PDF]

Japanese Journal of Cancer Research, 1992
The anticellular and antitumor activities of novel antitumor antibiotics, duocarmycins (DUMs), were examined against human and murine tumor cells. DUMs consist of live compounds, A, B1, B2, C1, and C2, which possess a pharmacophore similar to that of CC‐1065, a previously isolated antibiotic.
Gomi, Katsushige, Kobayashi, Eiji, Miyoshi, Katsunori, Ashizawa, Tadashi, Okamoto, Akihiko, Ogawa, Tatsuhiro, Katsumata, Shigeo, Mihara, Akira, Okabe, Masami, Hirata, Tadashi   +9 more
openaire   +2 more sources

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Journal for ImmunoTherapy of Cancer, 2020
Background Immunotherapy represents the future of clinical cancer treatment. The type of cancer cell death determines the antitumor immune response and thereby contributes to the efficacy of anticancer therapy and long-term survival of patients ...
Iuliia Efimova, E. Catanzaro, Louis Van der Meeren, Victoria D. Turubanova, H. Hammad, T. Mishchenko, M. Vedunova, C. Fimognari, C. Bachert, F. Coppieters, Steve Lefever, A. Skirtach, O. Krysko, D. Krysko   +13 more
semanticscholar   +1 more source

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Signal Transduction and Targeted Therapy, 2023
Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met inhibitors (c-Metis), yet the overall ...
Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, Yi-Long Wu, Meiyu Geng, Jing Ai   +18 more
doaj   +1 more source