Results 21 to 30 of about 531,165 (296)

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

Science immunology, 2020
PD-1 ablation regulates metabolism-driven lineage fate commitment of myeloid progenitors and differentiation of effector myeloid cells (see the related Focus by Rudd). A twist in the PD-1 tale Immunotherapies targeting programmed cell death protein 1 (PD-
L. Strauss, Mohamed A. Mahmoud, J. Weaver, Natalia M. Tijaro-Ovalle, A. Christofides, Qi Wang, R. Pal, Min Yuan, J. Asara, N. Patsoukis, V. Boussiotis   +10 more
semanticscholar   +1 more source

Disporum nanchuanense (Colchicaceae), a new species from Chongqing, China [PDF]

PhytoKeys, 2019
Disporum nanchuanense (Colchicaceae), a new species from Jinfo Mountain National Nature Reserve, Nanchuan District, Chongqing, China, is described and illustrated. It is similar to D. longistylum and D.
Xinxin Zhu, Shuai Liao, Sirong Yi
doaj   +3 more sources

Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy

Frontiers in Pharmacology, 2023
Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main
Changlin Zhen, Changlin Zhen, Xunxun Wu, Jing Zhang, Jing Zhang, Dan Liu, Dan Liu, Guoli Li, Guoli Li, Yongbo Yan, Xiuzhen He, Xiuzhen He, Jiawei Miao, Jiawei Miao, Hongxia Song, Hongxia Song, Yifan Yan, Yifan Yan, Yonghui Zhang, Yonghui Zhang   +19 more
doaj   +1 more source

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Frontiers in Immunology, 2020
The success of cancer immunotherapy relies on the knowledge of the tumor microenvironment and the immune evasion mechanisms in which the tumor, stroma, and infiltrating immune cells function in a complex network.
A. Labani-Motlagh, Mehrnoush Ashja-Mahdavi, A. Loskog   +2 more
semanticscholar   +1 more source

Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells

Molecular Cancer Therapeutics, 2021
Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a), with a ...
D. Okajima, Satoru Yasuda, T. Maejima, Tsuyoshi Karibe, K. Sakurai, T. Aida, Tadashi Toki, J. Yamaguchi, Michiko Kitamura, Reiko Kamei, Tomomichi Fujitani, T. Honda, T. Shibutani, Sumie Muramatsu, T. Nakada, R. Goto, S. Takahashi, M. Yamaguchi, H. Hamada, Yutaka Noguchi, M. Murakami, Yuki Abe, T. Agatsuma   +22 more
semanticscholar   +1 more source

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Nature Communications, 2019
Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic ...
Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang   +22 more
doaj   +1 more source

A novel STING agonist with systemic and durable anti‐tumour activity

Clinical and Translational Discovery, 2023
Background Stimulator of interferon genes (STING) has emerged as a crucial and promising target in tumor immunotherapy in recent years. Its agonists play a vital role in activating both innate and adaptive immune responses to combat cancer.
Xiyuan Wang, Ancheng Shen, Yan Zhang, Xiaoxu Chen, Jian Ding, Ao Zhang, Meiyu Geng, Chunyong Ding, Zuoquan Xie   +8 more
doaj   +1 more source

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity.

Molecules and Cells, 2021
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen infection.
Junwei Hou, Jung-Mao Hsu, M. Hung
semanticscholar   +1 more source

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Acta Pharmaceutica Sinica B, 2018
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation ...
Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang   +3 more
doaj   +1 more source

Interactions between gold nanoparticles with different morphologies and human serum albumin

Frontiers in Chemistry, 2023
Introduction: Three different shapes of gold nanoparticles were synthesized in this experiment. At the same time, studies compared their effects with human serum albumin (HSA).Methods: Gold nanoparticles (AuNPs) with three different morphologies, such as,
Jiahui Dai, Chao Chen, Man Yin, Huixing Li, Wenbo Li, Zhaowei Zhang, Qian Wang, Zhongyu Du, Xiangyu Xu, Yunfei Wang   +9 more
doaj   +1 more source